Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35354 |
Resumo: | Universidade Federal do Ceará. Hospital São José de Doenças Infecciosas. Fortaleza, CE, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. |
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Fievez, Aline Mireille da CunhaFreitas, Maria Luciana SilvaSousa, Anastácio de QueirozOliveira, Joanna R. SantosCruz, Alda M. da2019-09-05T14:12:35Z2019-09-05T14:12:35Z2019FIEVEZ, Aline Mireille da Cunha et al. Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients. Plos One, v. 14, n. 3, p. 1-15, Mar. 2019.1932-6203https://www.arca.fiocruz.br/handle/icict/3535410.1371/journal.pone.0214413engPublic Library of ScienceNíveis baixosLeptinaParâmetrosLeishmaniose visceralPacientesVisceral LeishmaniasisLeptinPatientsParametersLower levelsLower levels of leptin are associated with severity parameters in visceral leishmaniasis patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Ceará. Hospital São José de Doenças Infecciosas. Fortaleza, CE, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasilniversidade Federal do Ceará. Hospital São José de Doenças Infecciosas. Fortaleza, CE, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Instituto Federal de Educação, Ciência e Tecnologia. Núcleo de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Ri de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Ri de Janeiro, RJ, Brasil.Visceral leishmaniasis (VL) is the most severe clinical form of leishmaniasis, and if untreated may be fatal. It affects important organs of the immune system and is characterized by a specific immunosuppression, along with intense cellular activation and cytokine storm. Moreover, VL is now recognized as a systemic inflammatory response syndrome (SIRS), in which multiple cytokines and other pro-inflammatory molecules are released. The action of these inflammatory mediators may be considered risk factors for poor prognosis and death. Leptin, a hormone derived from adipose tissue, has been described with several immunoregulatory functions in vitro and in vivo Leishmania infection models, particularly for enhancing the macrophage microbicidal mechanisms. Considering that evaluation of immunologic parameters that may be associated with this clinical scenario may help to decrease VL lethality, we evaluated whether leptin is associated with VL pathogenesis. Thirty-one patients were recruited in the active phase of VL, of which 22 were followed up until one month after therapy (1mpt). Except for creatinine levels, all clinical parameters were altered in active VL patients, especially leucocyte counts and albumin and hemoglobin levels. Also, elevated levels of lipopolysaccharide (LPS), immunoglobulins (Ig)G1 and G3 anti-Leishmania and interleukins (IL)-6 and -10 were higher than in healthy individuals. In contrast, active VL patients presented diminished serum leptin levels and positive correlation with leukocytes counts and hemoglobin and albumin levels. After 1mpt, VL patients showed a significant increase in leptin levels, reaching values similar to healthy volunteers. As expected, only LPS levels remained elevated after 1mpt. These findings suggest that leptin levels are affected in Leishmania infection and the correlation with important parameters associated with the prognosis of VL points to the involvement of this molecule in VL immunopathogenesis. Additional studies are needed to evaluate the possibility of leptin as a prognostic marker of VL.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35354/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMariaLFreitas_AldaMCruz_etal_IOC_2019.pdfMariaLFreitas_AldaMCruz_etal_IOC_2019.pdfapplication/pdf2042927https://www.arca.fiocruz.br/bitstream/icict/35354/2/MariaLFreitas_AldaMCruz_etal_IOC_2019.pdf26496e11aca9aaaf779c0b1f74d84c8bMD52TEXTMariaLFreitas_AldaMCruz_etal_IOC_2019.pdf.txtMariaLFreitas_AldaMCruz_etal_IOC_2019.pdf.txtExtracted texttext/plain45151https://www.arca.fiocruz.br/bitstream/icict/35354/3/MariaLFreitas_AldaMCruz_etal_IOC_2019.pdf.txt21a06a8b2c4cb67d75159b9227484e52MD53icict/353542019-09-06 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dc.title.pt_BR.fl_str_mv |
Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients |
title |
Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients |
spellingShingle |
Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients Fievez, Aline Mireille da Cunha Níveis baixos Leptina Parâmetros Leishmaniose visceral Pacientes Visceral Leishmaniasis Leptin Patients Parameters Lower levels |
title_short |
Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients |
title_full |
Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients |
title_fullStr |
Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients |
title_full_unstemmed |
Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients |
title_sort |
Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients |
author |
Fievez, Aline Mireille da Cunha |
author_facet |
Fievez, Aline Mireille da Cunha Freitas, Maria Luciana Silva Sousa, Anastácio de Queiroz Oliveira, Joanna R. Santos Cruz, Alda M. da |
author_role |
author |
author2 |
Freitas, Maria Luciana Silva Sousa, Anastácio de Queiroz Oliveira, Joanna R. Santos Cruz, Alda M. da |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Fievez, Aline Mireille da Cunha Freitas, Maria Luciana Silva Sousa, Anastácio de Queiroz Oliveira, Joanna R. Santos Cruz, Alda M. da |
dc.subject.other.pt_BR.fl_str_mv |
Níveis baixos Leptina Parâmetros Leishmaniose visceral Pacientes |
topic |
Níveis baixos Leptina Parâmetros Leishmaniose visceral Pacientes Visceral Leishmaniasis Leptin Patients Parameters Lower levels |
dc.subject.en.pt_BR.fl_str_mv |
Visceral Leishmaniasis Leptin Patients Parameters Lower levels |
description |
Universidade Federal do Ceará. Hospital São José de Doenças Infecciosas. Fortaleza, CE, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-09-05T14:12:35Z |
dc.date.available.fl_str_mv |
2019-09-05T14:12:35Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FIEVEZ, Aline Mireille da Cunha et al. Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients. Plos One, v. 14, n. 3, p. 1-15, Mar. 2019. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/35354 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0214413 |
identifier_str_mv |
FIEVEZ, Aline Mireille da Cunha et al. Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients. Plos One, v. 14, n. 3, p. 1-15, Mar. 2019. 1932-6203 10.1371/journal.pone.0214413 |
url |
https://www.arca.fiocruz.br/handle/icict/35354 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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FIOCRUZ |
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FIOCRUZ |
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