A clinical scoring system to predict long-term arthralgia in Chikungunya disease: A cohort study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42835 |
Resumo: | This work was supported in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) [Finance Code 001], Conselho Nacional de Desenvolvimento Cientifico e Tecnológico [439967/2016-3], Programa de Excelência em Pesquisa [420765/ 2017-4] and Financiadora de Estudos e Projetos [MCTIC/FINEP/FNDCT 01/2016 ZIKA – 0416006000]. AB and MB-N are CNPq fellows. The funding organizations had no role in the study design, data collection, data interpretation or writing of this report. |
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Moraes, Laise deCerqueira-Silva, ThiagoNobrega, VictorAkrami, KevanSantos, Luciane AmorimOrge, CibeleCasais, PaulaCambui, LaisRampazzo, Rita de Cássia PontelloTrinta, Karen SoaresMontalbano, Camila AmatoTeixeira, Maria JaniaCavalcante, Luciano PamplonaAndrade, Bruno de BezerrilCunha, Rivaldo Venâncio daKrieger, Marco AurélioBarral-Netto, ManoelBarral, AldinaKhouri, RicardoBoaventura, Viviane Sampaio2020-08-19T00:02:57Z2020-08-19T00:02:57Z2020MORAES, Laise de et al. A clinical scoring system to predict long-termarthralgia in Chikungunya disease: a cohort study. PLoS Neglected Tropical Diseases, v. 14, n. 7, p. 1-14, 2020.1935-2735https://www.arca.fiocruz.br/handle/icict/4283510.1371/journal.pntd.00084671935-2735This work was supported in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) [Finance Code 001], Conselho Nacional de Desenvolvimento Cientifico e Tecnológico [439967/2016-3], Programa de Excelência em Pesquisa [420765/ 2017-4] and Financiadora de Estudos e Projetos [MCTIC/FINEP/FNDCT 01/2016 ZIKA – 0416006000]. AB and MB-N are CNPq fellows. The funding organizations had no role in the study design, data collection, data interpretation or writing of this report.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Division of Infectious Disease. Department of Medicine. University of California. San Diego, California, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Mato Grosso do Sul. Faculdade de Medicina. Campo Grande, MS, Brasil.Universidade Federal do Ceará. Faculdade de Medicina. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Faculdade de Medicina. Fortaleza, CE, Brasil.Universidade Federal de Santa Catarina. Centro de Ciências Agrárias. Departamento de Fitotecnia. Florianópolis, SC, Brasil.Universidade Federal do Mato Grosso do Sul. Faculdade de Medicina. Campo Grande, MS, Brasil. / Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Rega Institute for Medical Research. KU Leuven, Leuven, Belgium.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Hospital Santa Izabel. Santa Casa de Misericórdia da Bahia. Serviço Otorrinolaringologia. Salvador, BA, Brasil.Chikungunya virus (CHIKV) has caused worldwide epidemics that impose a major burdenon health systems. Approximately half of infected individuals develop chronic debilitating arthralgia, affecting their quality of life. Here, we identified the relevant clinical and demographic variables in the acute phase of CHIKV infection prospectively linked to chronic arthralgia to elaborate a prognostic scoring system. As methods had that acute CHIKV infection cases (n = 134) confirmed by serology or molecular test were examined <10 days of disease onset and followed for one year to evaluate for disease progression. Potential risk factors for chronic arthralgia were evaluated by multivariate analysis to develop a prognostic scoring system, which was subsequently tested in an independent validation cohort consisting of 42 individuals. As resulted, a total of 107 out of 134 (80%) acute CHIKV-confirmed cases from the derivation cohort were re-examined one year after enrollment. Chronic arthralgia post-CHIKV infection wasdiagnosed in 64 (60%). Five of the 12 parameters evaluated in the acute phase were statistically associated with persistent arthralgia and were further tested by Bayesian analysis.These variables were weighted to yield a prognosis score denominated SHERA (Sex,Hypertension, Edema, Retroocular pain, Age), which exhibited 81.3% accuracy in predicting long-term arthralgia post-CHIKV infection in the derivation cohort, and 76.5% accuracy in the validation cohort. Thereby conclude that the simplified and externally validated prognostic scoring system, SHERA, is a useful method to screen acutely CHIKV-infected patients at elevated risk of chronic arthralgia whowill benefit from specific interventions. This tool could guide public health policies, particularly in resource-constrained settings.porPublic Library of ScienceA clinical scoring system to predict long-term arthralgia in Chikungunya disease: A cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleChikungunya virusArthralgiaRisk FactorsPrognosisVirus ChikungunyaFactores de RiesgoPronósticoVirus du chikungunyaArthralgieFacteurs de risquePronosticVírus ChikungunyaArtralgiaFatores de RiscoPrognósticoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
A clinical scoring system to predict long-term arthralgia in Chikungunya disease: A cohort study |
| title |
A clinical scoring system to predict long-term arthralgia in Chikungunya disease: A cohort study |
| spellingShingle |
A clinical scoring system to predict long-term arthralgia in Chikungunya disease: A cohort study Moraes, Laise de Chikungunya virus Arthralgia Risk Factors Prognosis Virus Chikungunya Factores de Riesgo Pronóstico Virus du chikungunya Arthralgie Facteurs de risque Pronostic Vírus Chikungunya Artralgia Fatores de Risco Prognóstico |
| title_short |
A clinical scoring system to predict long-term arthralgia in Chikungunya disease: A cohort study |
| title_full |
A clinical scoring system to predict long-term arthralgia in Chikungunya disease: A cohort study |
| title_fullStr |
A clinical scoring system to predict long-term arthralgia in Chikungunya disease: A cohort study |
| title_full_unstemmed |
A clinical scoring system to predict long-term arthralgia in Chikungunya disease: A cohort study |
| title_sort |
A clinical scoring system to predict long-term arthralgia in Chikungunya disease: A cohort study |
| author |
Moraes, Laise de |
| author_facet |
Moraes, Laise de Cerqueira-Silva, Thiago Nobrega, Victor Akrami, Kevan Santos, Luciane Amorim Orge, Cibele Casais, Paula Cambui, Lais Rampazzo, Rita de Cássia Pontello Trinta, Karen Soares Montalbano, Camila Amato Teixeira, Maria Jania Cavalcante, Luciano Pamplona Andrade, Bruno de Bezerril Cunha, Rivaldo Venâncio da Krieger, Marco Aurélio Barral-Netto, Manoel Barral, Aldina Khouri, Ricardo Boaventura, Viviane Sampaio |
| author_role |
author |
| author2 |
Cerqueira-Silva, Thiago Nobrega, Victor Akrami, Kevan Santos, Luciane Amorim Orge, Cibele Casais, Paula Cambui, Lais Rampazzo, Rita de Cássia Pontello Trinta, Karen Soares Montalbano, Camila Amato Teixeira, Maria Jania Cavalcante, Luciano Pamplona Andrade, Bruno de Bezerril Cunha, Rivaldo Venâncio da Krieger, Marco Aurélio Barral-Netto, Manoel Barral, Aldina Khouri, Ricardo Boaventura, Viviane Sampaio |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Moraes, Laise de Cerqueira-Silva, Thiago Nobrega, Victor Akrami, Kevan Santos, Luciane Amorim Orge, Cibele Casais, Paula Cambui, Lais Rampazzo, Rita de Cássia Pontello Trinta, Karen Soares Montalbano, Camila Amato Teixeira, Maria Jania Cavalcante, Luciano Pamplona Andrade, Bruno de Bezerril Cunha, Rivaldo Venâncio da Krieger, Marco Aurélio Barral-Netto, Manoel Barral, Aldina Khouri, Ricardo Boaventura, Viviane Sampaio |
| dc.subject.en.pt_BR.fl_str_mv |
Chikungunya virus Arthralgia Risk Factors Prognosis |
| topic |
Chikungunya virus Arthralgia Risk Factors Prognosis Virus Chikungunya Factores de Riesgo Pronóstico Virus du chikungunya Arthralgie Facteurs de risque Pronostic Vírus Chikungunya Artralgia Fatores de Risco Prognóstico |
| dc.subject.es.pt_BR.fl_str_mv |
Virus Chikungunya Factores de Riesgo Pronóstico |
| dc.subject.fr.pt_BR.fl_str_mv |
Virus du chikungunya Arthralgie Facteurs de risque Pronostic |
| dc.subject.decs.pt_BR.fl_str_mv |
Vírus Chikungunya Artralgia Fatores de Risco Prognóstico |
| description |
This work was supported in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) [Finance Code 001], Conselho Nacional de Desenvolvimento Cientifico e Tecnológico [439967/2016-3], Programa de Excelência em Pesquisa [420765/ 2017-4] and Financiadora de Estudos e Projetos [MCTIC/FINEP/FNDCT 01/2016 ZIKA – 0416006000]. AB and MB-N are CNPq fellows. The funding organizations had no role in the study design, data collection, data interpretation or writing of this report. |
| publishDate |
2020 |
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2020-08-19T00:02:57Z |
| dc.date.available.fl_str_mv |
2020-08-19T00:02:57Z |
| dc.date.issued.fl_str_mv |
2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
MORAES, Laise de et al. A clinical scoring system to predict long-termarthralgia in Chikungunya disease: a cohort study. PLoS Neglected Tropical Diseases, v. 14, n. 7, p. 1-14, 2020. |
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https://www.arca.fiocruz.br/handle/icict/42835 |
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1935-2735 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0008467 |
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1935-2735 |
| identifier_str_mv |
MORAES, Laise de et al. A clinical scoring system to predict long-termarthralgia in Chikungunya disease: a cohort study. PLoS Neglected Tropical Diseases, v. 14, n. 7, p. 1-14, 2020. 1935-2735 10.1371/journal.pntd.0008467 |
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Public Library of Science |
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