Evolution of the innate and adaptive immune response in women with acute Zika virus infection

Detalhes bibliográficos
Autor(a) principal: Tonnerre, Pierre
Data de Publicação: 2020
Outros Autores: Melgaço, Juliana G., Torres-Cornejo, Almudena, Pinto, Marcelo A., Yue, Constanze, Blümel, Johannes, Sousa, Paulo Sergio Fonseca de, Mello, Vinicius da Motta de, Moran, Julio, Filippis, Ana M Bispo de, Wolski, David, Grifoni, Alba, Sette, Alessandro, Barouch, Dan H., Hoogeveen, Ruben C., Baylis, Sally A., Lauer, Georg M., Lewis-Ximenez, Lia L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42475
Resumo: Acesso aberto em 30/07/2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938397/pdf/nihms-1541472.pdf
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spelling Tonnerre, PierreMelgaço, Juliana G.Torres-Cornejo, AlmudenaPinto, Marcelo A.Yue, ConstanzeBlümel, JohannesSousa, Paulo Sergio Fonseca deMello, Vinicius da Motta deMoran, JulioFilippis, Ana M Bispo deWolski, DavidGrifoni, AlbaSette, AlessandroBarouch, Dan H.Hoogeveen, Ruben C.Baylis, Sally A.Lauer, Georg M.Lewis-Ximenez, Lia L.2020-07-30T19:16:02Z2020-07-30T19:16:02Z2020TONNERRE, Pierre et al. Evolution of the innate and adaptive immune response in women with acute Zika virus infection. Nat. Mocrobiol., v. 5, n. 1, p. 76-83, Jan. 2020.2058-5276https://www.arca.fiocruz.br/handle/icict/4247510.1038/s41564-019-0618-zAcesso aberto em 30/07/2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938397/pdf/nihms-1541472.pdf.Massachusetts General Hospital and Harvard Medical School, Boston. Division of Gastroenterology. Boston, MA, USA..Massachusetts General Hospital and Harvard Medical School, Boston. Division of Gastroenterology. Boston, MA, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil..Massachusetts General Hospital and Harvard Medical School, Boston. Division of Gastroenterology. Boston, MA, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Paul-Ehrlich-Institut. Division of Virology. Langen, Germany.Paul-Ehrlich-Institut. Division of Virology. Langen, Germany.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Dr. Julio Moran Laboratories. Herrliberg, Zurich, Switzerland.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Massachusetts General Hospital and Harvard Medical School, Boston. Division of Gastroenterology. Boston, MA, USA.La Jolla Institute for Immunology. Division of Vaccine Discovery. La Jolla, CA, USA.La Jolla Institute for Immunology. Division of Vaccine Discovery. La Jolla, CA, USA / University of California San Diego. Department of Medicine. La Jolla, CA, USA.Ragon Institute of MGH, MIT and Harvard. Cambridge, MA, USA / Beth Israel Deaconess Medical Center. Center for Virology and Vaccine Research. Boston, MA, USA,Massachusetts General Hospital and Harvard Medical School, Boston. Division of Gastroenterology. Boston, MA, USA.Paul-Ehrlich-Institut. Division of Virology. Langen, Germany.Zika virus (ZIKV) is a flavivirus that is closely related to other human pathogens, such as dengue virus (DENV)1. Primary transmission usually involves Aedes aegypti, which has expanded its distribution range considerably2, although rarer infection routes, including mother-to-fetus transmission, sexual contact and blood transfusion, have also been observed3-7. Primary ZIKV infection is usually asymptomatic or mild in adults, with quickly resolved blood viraemia, but ZIKV might persist for months in saliva, urine, semen, breast milk and the central nervous system8-12. During a recent ZIKV outbreak in South America, substantial numbers of neurological complications, such as Guillain-Barré syndrome, were reported13,14 together with cases of microcephaly and associated developmental problems in infants born to women infected with ZIKV during pregnancy15-20, highlighting the clinical importance of this infection. Analyses of the human immune response to ZIKV are lacking21-28, but the recent outbreak has provided an opportunity to assess ZIKV immunity using current immunological methods. Here, we comprehensively assess the acute innate and adaptive immune response to ZIKV infection in ten women who were recruited during early infection and followed through reconvalescence. We define a cascade of events that lead to immunological control of ZIKV, with previous exposure to DENV impacting some, but not all, mediators of antiviral immunity.engNature ResearchZika virusInfecção agudaResposta imune inataMulheresEvoluçãoZika virusImmune responseAcute infectionWomenEvolutionEvolution of the innate and adaptive immune response in women with acute Zika virus infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Evolution of the innate and adaptive immune response in women with acute Zika virus infection
title Evolution of the innate and adaptive immune response in women with acute Zika virus infection
spellingShingle Evolution of the innate and adaptive immune response in women with acute Zika virus infection
Tonnerre, Pierre
Zika virus
Infecção aguda
Resposta imune inata
Mulheres
Evolução
Zika virus
Immune response
Acute infection
Women
Evolution
title_short Evolution of the innate and adaptive immune response in women with acute Zika virus infection
title_full Evolution of the innate and adaptive immune response in women with acute Zika virus infection
title_fullStr Evolution of the innate and adaptive immune response in women with acute Zika virus infection
title_full_unstemmed Evolution of the innate and adaptive immune response in women with acute Zika virus infection
title_sort Evolution of the innate and adaptive immune response in women with acute Zika virus infection
author Tonnerre, Pierre
author_facet Tonnerre, Pierre
Melgaço, Juliana G.
Torres-Cornejo, Almudena
Pinto, Marcelo A.
Yue, Constanze
Blümel, Johannes
Sousa, Paulo Sergio Fonseca de
Mello, Vinicius da Motta de
Moran, Julio
Filippis, Ana M Bispo de
Wolski, David
Grifoni, Alba
Sette, Alessandro
Barouch, Dan H.
Hoogeveen, Ruben C.
Baylis, Sally A.
Lauer, Georg M.
Lewis-Ximenez, Lia L.
author_role author
author2 Melgaço, Juliana G.
Torres-Cornejo, Almudena
Pinto, Marcelo A.
Yue, Constanze
Blümel, Johannes
Sousa, Paulo Sergio Fonseca de
Mello, Vinicius da Motta de
Moran, Julio
Filippis, Ana M Bispo de
Wolski, David
Grifoni, Alba
Sette, Alessandro
Barouch, Dan H.
Hoogeveen, Ruben C.
Baylis, Sally A.
Lauer, Georg M.
Lewis-Ximenez, Lia L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tonnerre, Pierre
Melgaço, Juliana G.
Torres-Cornejo, Almudena
Pinto, Marcelo A.
Yue, Constanze
Blümel, Johannes
Sousa, Paulo Sergio Fonseca de
Mello, Vinicius da Motta de
Moran, Julio
Filippis, Ana M Bispo de
Wolski, David
Grifoni, Alba
Sette, Alessandro
Barouch, Dan H.
Hoogeveen, Ruben C.
Baylis, Sally A.
Lauer, Georg M.
Lewis-Ximenez, Lia L.
dc.subject.other.pt_BR.fl_str_mv Zika virus
Infecção aguda
Resposta imune inata
Mulheres
Evolução
topic Zika virus
Infecção aguda
Resposta imune inata
Mulheres
Evolução
Zika virus
Immune response
Acute infection
Women
Evolution
dc.subject.en.pt_BR.fl_str_mv Zika virus
Immune response
Acute infection
Women
Evolution
description Acesso aberto em 30/07/2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938397/pdf/nihms-1541472.pdf
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-07-30T19:16:02Z
dc.date.available.fl_str_mv 2020-07-30T19:16:02Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TONNERRE, Pierre et al. Evolution of the innate and adaptive immune response in women with acute Zika virus infection. Nat. Mocrobiol., v. 5, n. 1, p. 76-83, Jan. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42475
dc.identifier.issn.pt_BR.fl_str_mv 2058-5276
dc.identifier.doi.none.fl_str_mv 10.1038/s41564-019-0618-z
identifier_str_mv TONNERRE, Pierre et al. Evolution of the innate and adaptive immune response in women with acute Zika virus infection. Nat. Mocrobiol., v. 5, n. 1, p. 76-83, Jan. 2020.
2058-5276
10.1038/s41564-019-0618-z
url https://www.arca.fiocruz.br/handle/icict/42475
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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