Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis

Detalhes bibliográficos
Autor(a) principal: Oliveira, Gisele P.
Data de Publicação: 2009
Outros Autores: Oliveira, Mariana B. G., Santos, Raquel S., Lima, Letícia D., Dias, Cristina M., Ab' Saber, Alexandre M., Teodoro, Walcy R., Capelozzi, Vera L., Gomes, Rachel N., Bozza, Patrícia T., Pelosi, Paolo, Rocco, Patricia R. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28997
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.
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spelling Oliveira, Gisele P.Oliveira, Mariana B. G.Santos, Raquel S.Lima, Letícia D.Dias, Cristina M.Ab' Saber, Alexandre M.Teodoro, Walcy R.Capelozzi, Vera L.Gomes, Rachel N.Bozza, Patrícia T.Pelosi, PaoloRocco, Patricia R. M.2018-09-23T14:31:33Z2018-09-23T14:31:33Z2009OLIVEIRA, Gisele P. et al. Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis. Critical Care, v.13, R74, 11p, May 2009.1364-8535https://www.arca.fiocruz.br/handle/icict/2899710.1186/cc78881466-609XengBioMed Centralglutamina intravenosalesão pulmonarórgão distalsepse abdominalIntravenous glutaminelungdistal organabdominal sepisexperimental modelIntravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.University of Insubria. Department of Ambient, Health and Safety. Varese, Italy.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.The protective effect of glutamine, as a pharmacological agent against lung injury, has been reported in experimental sepsis; however, its efficacy at improving oxygenation and lung mechanics, attenuating diaphragm and distal organ injury has to be better elucidated. In the present study, we tested the hypothesis that a single early intravenous dose of glutamine was associated not only with the improvement of lung morpho-function, but also the reduction of the inflammatory process and epithelial cell apoptosis in kidney, liver, and intestine villi.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28997/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALracheln_gomes_etal_IOC_2009.pdfracheln_gomes_etal_IOC_2009.pdfapplication/pdf7181957https://www.arca.fiocruz.br/bitstream/icict/28997/2/racheln_gomes_etal_IOC_2009.pdfdfbb7e9756a5da48fb474534a1d1d688MD52TEXTracheln_gomes_etal_IOC_2009.pdf.txtracheln_gomes_etal_IOC_2009.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis
title Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis
spellingShingle Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis
Oliveira, Gisele P.
glutamina intravenosa
lesão pulmonar
órgão distal
sepse abdominal
Intravenous glutamine
lung
distal organ
abdominal sepis
experimental model
title_short Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis
title_full Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis
title_fullStr Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis
title_full_unstemmed Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis
title_sort Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis
author Oliveira, Gisele P.
author_facet Oliveira, Gisele P.
Oliveira, Mariana B. G.
Santos, Raquel S.
Lima, Letícia D.
Dias, Cristina M.
Ab' Saber, Alexandre M.
Teodoro, Walcy R.
Capelozzi, Vera L.
Gomes, Rachel N.
Bozza, Patrícia T.
Pelosi, Paolo
Rocco, Patricia R. M.
author_role author
author2 Oliveira, Mariana B. G.
Santos, Raquel S.
Lima, Letícia D.
Dias, Cristina M.
Ab' Saber, Alexandre M.
Teodoro, Walcy R.
Capelozzi, Vera L.
Gomes, Rachel N.
Bozza, Patrícia T.
Pelosi, Paolo
Rocco, Patricia R. M.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Gisele P.
Oliveira, Mariana B. G.
Santos, Raquel S.
Lima, Letícia D.
Dias, Cristina M.
Ab' Saber, Alexandre M.
Teodoro, Walcy R.
Capelozzi, Vera L.
Gomes, Rachel N.
Bozza, Patrícia T.
Pelosi, Paolo
Rocco, Patricia R. M.
dc.subject.other.pt_BR.fl_str_mv glutamina intravenosa
lesão pulmonar
órgão distal
sepse abdominal
topic glutamina intravenosa
lesão pulmonar
órgão distal
sepse abdominal
Intravenous glutamine
lung
distal organ
abdominal sepis
experimental model
dc.subject.en.pt_BR.fl_str_mv Intravenous glutamine
lung
distal organ
abdominal sepis
experimental model
description Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2018-09-23T14:31:33Z
dc.date.available.fl_str_mv 2018-09-23T14:31:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Gisele P. et al. Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis. Critical Care, v.13, R74, 11p, May 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28997
dc.identifier.issn.pt_BR.fl_str_mv 1364-8535
dc.identifier.doi.none.fl_str_mv 10.1186/cc7888
dc.identifier.eissn.none.fl_str_mv 1466-609X
identifier_str_mv OLIVEIRA, Gisele P. et al. Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis. Critical Care, v.13, R74, 11p, May 2009.
1364-8535
10.1186/cc7888
1466-609X
url https://www.arca.fiocruz.br/handle/icict/28997
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/28997/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/28997/2/racheln_gomes_etal_IOC_2009.pdf
https://www.arca.fiocruz.br/bitstream/icict/28997/3/racheln_gomes_etal_IOC_2009.pdf.txt
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