Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice

Detalhes bibliográficos
Autor(a) principal: Tendler, Miriam
Data de Publicação: 1992
Outros Autores: Pinto, Roberto Magalhães, Lima, Antonio de Oliveira, Savino, Wilson, Katz, Naftale
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33623
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Helmintologia. Rio de Janeiro, RJ, Brasil.
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spelling Tendler, MiriamPinto, Roberto MagalhãesLima, Antonio de OliveiraSavino, WilsonKatz, Naftale2019-06-23T15:09:06Z2019-06-23T15:09:06Z1992TENDLER, Miriam et al. Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. 1, p. 281-286, 1992.0074-0276https://www.arca.fiocruz.br/handle/icict/3362310.1590/S0074-027619920005000531678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.VacinaçãoSchistosoma mansoniAntígenosModelo murinoVaccinationSchistosoma mansoniMurine modelAntigensVaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Helmintologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Helmintologia. Rio de Janeiro, RJ, Brasil.Fundação Ataulpho de Paiva. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilPrevious studies have shown that both permissive (mouse) and partially permissive (rabbit) hosts develop high levels of resistance against Schistosoma mansoni infection after vaccination with a multiple antigen extract (SE) obtained by incubation of living adult worms in saline, plus bacterial adjuvant. To investigate variables influencing SE-induced protection in murine schistosomiasis, a series of distinct vaccination protocols were performed focussing on the immunization dose, carrier systems, route, site and amplitude of challenge infection, and time between immunization and challenge. In addition, a new approach was adopted to evaluate SE protective activity, by means of population analysis of worm burden frequency distributions in a large scale study of vaccination in outbred Swiss mice. Distinct curves of frequency and a drastic difference in worm burden distribution of frequencies from SE-vaccinated × non-vaccinated mice were found. It was shown that SE could generate 75% mean protection in outbred mice even in the absence of adjuvant. In addition SE immunization was also able to induce full protection against lethal infection. SE-induced protection could be modulated by such parameters as dose of SE immunization/challenge interval, and route of cercariae injection. These data show that SE yields very high protective activity in outbred mice, and may provide a further insight for rational design of a vaccine in experimental schistosomiasis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33623/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWilsonSavino_MiriamTendler_etal_IOC_1992.pdfWilsonSavino_MiriamTendler_etal_IOC_1992.pdfapplication/pdf348194https://www.arca.fiocruz.br/bitstream/icict/33623/2/WilsonSavino_MiriamTendler_etal_IOC_1992.pdf8a9fca5f782f43bbe77f4e2bc9b6956cMD52TEXTWilsonSavino_MiriamTendler_etal_IOC_1992.pdf.txtWilsonSavino_MiriamTendler_etal_IOC_1992.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
title Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
spellingShingle Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
Tendler, Miriam
Vacinação
Schistosoma mansoni
Antígenos
Modelo murino
Vaccination
Schistosoma mansoni
Murine model
Antigens
title_short Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
title_full Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
title_fullStr Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
title_full_unstemmed Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
title_sort Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice
author Tendler, Miriam
author_facet Tendler, Miriam
Pinto, Roberto Magalhães
Lima, Antonio de Oliveira
Savino, Wilson
Katz, Naftale
author_role author
author2 Pinto, Roberto Magalhães
Lima, Antonio de Oliveira
Savino, Wilson
Katz, Naftale
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Tendler, Miriam
Pinto, Roberto Magalhães
Lima, Antonio de Oliveira
Savino, Wilson
Katz, Naftale
dc.subject.other.pt_BR.fl_str_mv Vacinação
Schistosoma mansoni
Antígenos
Modelo murino
topic Vacinação
Schistosoma mansoni
Antígenos
Modelo murino
Vaccination
Schistosoma mansoni
Murine model
Antigens
dc.subject.en.pt_BR.fl_str_mv Vaccination
Schistosoma mansoni
Murine model
Antigens
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Helmintologia. Rio de Janeiro, RJ, Brasil.
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2019-06-23T15:09:06Z
dc.date.available.fl_str_mv 2019-06-23T15:09:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TENDLER, Miriam et al. Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. 1, p. 281-286, 1992.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33623
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02761992000500053
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv TENDLER, Miriam et al. Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. 1, p. 281-286, 1992.
0074-0276
10.1590/S0074-02761992000500053
1678-8060
url https://www.arca.fiocruz.br/handle/icict/33623
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/33623/1/license.txt
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