Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1988 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35015 |
Resumo: | Rockefeller Foundation, INSERM and CNRS. |
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Dessein, Alain J.Begley, MaryDemeure, ChristianCaillol, DanièleFueri, JosetteReis, Mitermayer Galvão dosAndrade, Zilton de AraújoPrata, AluizioBina, José Carlos2019-08-23T14:13:20Z2019-08-23T14:13:20Z1988DESSEIN, Alain J. et al. Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen. Journal of Immunology, v. 140, n. 8, p. 2727-2736, 1988.0022-1767https://www.arca.fiocruz.br/handle/icict/35015Rockefeller Foundation, INSERM and CNRS.2020-01-12Centre d'Immunologie de Marseille-Luminy and Immunotech. Marseille, France.Centre d'Immunologie de Marseille-Luminy and Immunotech. Marseille, France.Centre d'Immunologie de Marseille-Luminy and Immunotech. Marseille, France.Centre d'Immunologie de Marseille-Luminy and Immunotech. Marseille, France.Centre d'Immunologie de Marseille-Luminy and Immunotech. Marseille, France.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Universidade de Brasília. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital das Clínicas. Salvador, BA, Brasil.The aim of this work was to determine whether human resistance to Schistosoma mansoni was assoctiated with increased antibody reactivity to certain larval surface Ag. To this end, young residents of a hyperendemic arera were selected for their low logic cure, and the reactivity of their sera to individual larval surface Ag determined at different times before and after treatment. The data showed that six Ag: 202, 165, 90 to 92, 85, 72 and 37 kDa are the principal targets on the larva of IgG in the sera of resistant subjects. The comparative study, by immunoblotting and ELISA on purified Ag, of the sera from hihg and low susceptibility subjects indicates that IgG reactivity toward the 37-kDa Ag may by associated with resistance. This work and ongoing vaccination trials carried out in mice suggest that the 37-kDa Ag may have vaccinating potentials.engAmerican Association of ImmunologistsSchistosoma MansoniResistênciaVacinaçãoAntigenoSchistosoma MansoniResistanceVaccinationAntigensHuman resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35015/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDessein AJ Human....1988.pdfDessein AJ Human....1988.pdfapplication/pdf3354620https://www.arca.fiocruz.br/bitstream/icict/35015/2/Dessein%20AJ%20Human....1988.pdfccc1e21baefa144e5aa9cf084d78aa0aMD52TEXTDessein AJ Human....1988.pdf.txtDessein AJ Human....1988.pdf.txtExtracted texttext/plain43649https://www.arca.fiocruz.br/bitstream/icict/35015/3/Dessein%20AJ%20Human....1988.pdf.txtcb9922a36283ea5990f13643d07c107eMD53icict/350152023-03-15 14:34:20.393oai:www.arca.fiocruz.br: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ório 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| dc.title.pt_BR.fl_str_mv |
Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen |
| title |
Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen |
| spellingShingle |
Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen Dessein, Alain J. Schistosoma Mansoni Resistência Vacinação Antigeno Schistosoma Mansoni Resistance Vaccination Antigens |
| title_short |
Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen |
| title_full |
Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen |
| title_fullStr |
Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen |
| title_full_unstemmed |
Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen |
| title_sort |
Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen |
| author |
Dessein, Alain J. |
| author_facet |
Dessein, Alain J. Begley, Mary Demeure, Christian Caillol, Danièle Fueri, Josette Reis, Mitermayer Galvão dos Andrade, Zilton de Araújo Prata, Aluizio Bina, José Carlos |
| author_role |
author |
| author2 |
Begley, Mary Demeure, Christian Caillol, Danièle Fueri, Josette Reis, Mitermayer Galvão dos Andrade, Zilton de Araújo Prata, Aluizio Bina, José Carlos |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Dessein, Alain J. Begley, Mary Demeure, Christian Caillol, Danièle Fueri, Josette Reis, Mitermayer Galvão dos Andrade, Zilton de Araújo Prata, Aluizio Bina, José Carlos |
| dc.subject.other.pt_BR.fl_str_mv |
Schistosoma Mansoni Resistência Vacinação Antigeno |
| topic |
Schistosoma Mansoni Resistência Vacinação Antigeno Schistosoma Mansoni Resistance Vaccination Antigens |
| dc.subject.en.pt_BR.fl_str_mv |
Schistosoma Mansoni Resistance Vaccination Antigens |
| description |
Rockefeller Foundation, INSERM and CNRS. |
| publishDate |
1988 |
| dc.date.issued.fl_str_mv |
1988 |
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2019-08-23T14:13:20Z |
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2019-08-23T14:13:20Z |
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DESSEIN, Alain J. et al. Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen. Journal of Immunology, v. 140, n. 8, p. 2727-2736, 1988. |
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https://www.arca.fiocruz.br/handle/icict/35015 |
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0022-1767 |
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DESSEIN, Alain J. et al. Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen. Journal of Immunology, v. 140, n. 8, p. 2727-2736, 1988. 0022-1767 |
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American Association of Immunologists |
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American Association of Immunologists |
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