New approaches in antimalarial drug discovery and development - A Review

Detalhes bibliográficos
Autor(a) principal: Aguiar, Anna Caroline Campos
Data de Publicação: 2012
Outros Autores: Rocha, Eliana Maria Mauricio da, Souza, Nicolli Bellotti de, França, Tanos Celmar Costa, Krettli, Antoniana Ursine
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7322
Resumo: CNPq (MCT/CNPq/CT-Saúde/MS/SCTIE/DECIT), FAPEMIG, FIOCRUZ (PDTIS, PAPES V) AUK, ACCA, NBS and WJC have fellowships from CNPq.
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spelling Aguiar, Anna Caroline CamposRocha, Eliana Maria Mauricio daSouza, Nicolli Bellotti deFrança, Tanos Celmar CostaKrettli, Antoniana Ursine2014-02-18T17:12:27Z2014-02-18T17:12:27Z2012AGUIAR, AnnCaroline Campos et al. New approaches in antimalarial drug discovery and development - A Review. Memórias do Instituto Oswaldo Cruz. 2012, vol.107, pp. 831-845.0074-0276https://www.arca.fiocruz.br/handle/icict/732210.1590/S0074-02762012000700001CNPq (MCT/CNPq/CT-Saúde/MS/SCTIE/DECIT), FAPEMIG, FIOCRUZ (PDTIS, PAPES V) AUK, ACCA, NBS and WJC have fellowships from CNPq.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil/ Universidade Federal de Minas Gerais. Programa de Pós-Graduação em Medicina Molecular. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil/ Universidade Federal de São João del Rey. Divinópolis, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil/ Universidade Federal de Minas Gerais. Programa de Pós-Graduação em Medicina Molecular. Belo Horizonte, MG, BrasilMalaria remains a major world health problem following the emergence and spread of Plasmodium falciparum that is resistant to the majority of antimalarial drugs. This problem has since been aggravated by a decreased sensitivity of Plasmodium vivax to chloroquine. This review discusses strategies for evaluating the antimalarial activity of new compounds in vitro and in animal models ranging from conventional tests to the latest high-throughput screening technologies. Antimalarial discovery approaches include the following: the discovery of antimalarials from natural sources, chemical modifications of existing antimalarials, the development of hybrid compounds, test-ing of commercially available drugs that have been approved for human use for other diseases and molecular model-ling using virtual screening technology and docking. Using these approaches, thousands of new drugs with known molecular specificity and active against P. falciparum have been selected. The inhibition of haemozoin formation in vitro, an indirect test that does not require P. falciparum cultures, has been described and this test is believed to improve antimalarial drug discovery. Clinical trials conducted with new funds from international agencies and the participation of several industries committed to the eradication of malaria should accelerate the discovery of drugs that are as effective as artemisinin derivatives, thus providing new hope for the control of malaria.engFundação Oswaldo CruzNew approaches in antimalarial drug discovery and development - A Reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehuman malariaPlasmodium falciparumantimalarialsdrug screeningchloroquineartemisinindrug resistanceinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL01_5.pdf01_5.pdfapplication/pdf1090141https://www.arca.fiocruz.br/bitstream/icict/7322/1/01_5.pdfb7efa0e3191cde26ad6affe098ec8ae5MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7322/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXT01_5.pdf.txt01_5.pdf.txtExtracted texttext/plain85034https://www.arca.fiocruz.br/bitstream/icict/7322/5/01_5.pdf.txt672eced2c4a971dcbe1a5dc1cb3d72cbMD55THUMBNAIL01_5.pdf.jpg01_5.pdf.jpgGenerated Thumbnailimage/jpeg2195https://www.arca.fiocruz.br/bitstream/icict/7322/4/01_5.pdf.jpg7b8d1c14682f30cc4c05e7957702abfbMD54icict/73222018-10-24 11:10:36.756oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-10-24T14:10:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv New approaches in antimalarial drug discovery and development - A Review
title New approaches in antimalarial drug discovery and development - A Review
spellingShingle New approaches in antimalarial drug discovery and development - A Review
Aguiar, Anna Caroline Campos
human malaria
Plasmodium falciparum
antimalarials
drug screening
chloroquine
artemisinin
drug resistance
title_short New approaches in antimalarial drug discovery and development - A Review
title_full New approaches in antimalarial drug discovery and development - A Review
title_fullStr New approaches in antimalarial drug discovery and development - A Review
title_full_unstemmed New approaches in antimalarial drug discovery and development - A Review
title_sort New approaches in antimalarial drug discovery and development - A Review
author Aguiar, Anna Caroline Campos
author_facet Aguiar, Anna Caroline Campos
Rocha, Eliana Maria Mauricio da
Souza, Nicolli Bellotti de
França, Tanos Celmar Costa
Krettli, Antoniana Ursine
author_role author
author2 Rocha, Eliana Maria Mauricio da
Souza, Nicolli Bellotti de
França, Tanos Celmar Costa
Krettli, Antoniana Ursine
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Aguiar, Anna Caroline Campos
Rocha, Eliana Maria Mauricio da
Souza, Nicolli Bellotti de
França, Tanos Celmar Costa
Krettli, Antoniana Ursine
dc.subject.en.pt_BR.fl_str_mv human malaria
Plasmodium falciparum
antimalarials
drug screening
chloroquine
artemisinin
drug resistance
topic human malaria
Plasmodium falciparum
antimalarials
drug screening
chloroquine
artemisinin
drug resistance
description CNPq (MCT/CNPq/CT-Saúde/MS/SCTIE/DECIT), FAPEMIG, FIOCRUZ (PDTIS, PAPES V) AUK, ACCA, NBS and WJC have fellowships from CNPq.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-02-18T17:12:27Z
dc.date.available.fl_str_mv 2014-02-18T17:12:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AGUIAR, AnnCaroline Campos et al. New approaches in antimalarial drug discovery and development - A Review. Memórias do Instituto Oswaldo Cruz. 2012, vol.107, pp. 831-845.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7322
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762012000700001
identifier_str_mv AGUIAR, AnnCaroline Campos et al. New approaches in antimalarial drug discovery and development - A Review. Memórias do Instituto Oswaldo Cruz. 2012, vol.107, pp. 831-845.
0074-0276
10.1590/S0074-02762012000700001
url https://www.arca.fiocruz.br/handle/icict/7322
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
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