Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome

Detalhes bibliográficos
Autor(a) principal: Mattos, Paulo Sérgio de Morais da Silveira
Data de Publicação: 2019
Outros Autores: Narendran, Gopalan, Akrami, Kevan, Fukutani, Kiyoshi Ferreira, Anbalagan, Selvaraj, Nayak, Kaustuv, Subramanyam, Sudha, Subramani, Rajasekaran, Vinhaes, Caian Leal de Azevedo, Souza, Deivide Oliveira de, Antonelli, Lis Ribeiro do Valle, Satagopan, Kumar, Porter, Brian O, Sher, Alan, Swaminathan, Soumya, Sereti, Irini, Andrade, Bruno de Bezerril
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32172
Resumo: Intramural Research Program of NIAID/NIH and by the Intramuralto- India grant from the US-India Co-operative research program. This study was also financed in part by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (Finance Code 001). The work of B.B.A. was supported by a grant from NIH (U01AI115940). P.S.S.M. was supported by a PhD fellowship from the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). K.F.F. received a fellowship from the Programa Nacional de Pós-Doutorado, CAPES. C.V. and D.S. are supported by FAPESB
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spelling Mattos, Paulo Sérgio de Morais da SilveiraNarendran, GopalanAkrami, KevanFukutani, Kiyoshi FerreiraAnbalagan, SelvarajNayak, KaustuvSubramanyam, SudhaSubramani, RajasekaranVinhaes, Caian Leal de AzevedoSouza, Deivide Oliveira deAntonelli, Lis Ribeiro do ValleSatagopan, KumarPorter, Brian OSher, AlanSwaminathan, SoumyaSereti, IriniAndrade, Bruno de Bezerril2019-03-20T13:02:59Z2019-03-20T13:02:59Z2019MATTOS, Paulo Sérgio de Morais da Silveira et al. Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome. Scientific Reports, v. 9, p. 1-9, 2019.2045-2322https://www.arca.fiocruz.br/handle/icict/3217210.1038/s41598-018-37846-3Intramural Research Program of NIAID/NIH and by the Intramuralto- India grant from the US-India Co-operative research program. This study was also financed in part by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (Finance Code 001). The work of B.B.A. was supported by a grant from NIH (U01AI115940). P.S.S.M. was supported by a PhD fellowship from the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). K.F.F. received a fellowship from the Programa Nacional de Pós-Doutorado, CAPES. C.V. and D.S. are supported by FAPESBFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.National Institute for Research in Tuberculosis. Chennai, India.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / University of California. Department of Medicine. Division of Infectious Diseases. San Diego, United States of America.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.National Institute for Research in Tuberculosis. Chennai, India.National Institute for Research in Tuberculosis. Chennai, India.National Institute for Research in Tuberculosis. Chennai, India.National Institute for Research in Tuberculosis. Chennai, India.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brasil.Government Hospital of Thoracic Medicine. Tambaram, Chennai, India.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Immunoregulation. Clinical HIV Pathogenesis Section. Bethesda, Maryland, United States of America.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, Maryland, United States of America.National Institute for Research in Tuberculosis. Chennai, India.Government Hospital of Thoracic Medicine. Tambaram, Chennai, India.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Wellcome Trust Centre for Infectious Disease Research in Africa. Cape Town, Republic of South Africa / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil / Vanderbilt University School of Medicine. Division of Department of Medicine. Infectious Diseases. Nashville, Tennessee, United States of America.Immune reconstitution inflammatory syndrome (IRIS) occurs in up to 40% of individuals co-infected with pulmonary tuberculosis (PTB) and HIV, primarily upon antiretroviral therapy (ART) initiation. Phenotypic changes in T-cells during TB-IRIS and their relationship with systemic inflammation are not fully understood. In this prospective cohort study, we followed 48 HIV-positive patients with PTB from South India before and after ART initiation, examining T-lymphocyte subsets and inflammatory biomarkers in peripheral blood. Quantification of naïve (CD27+CD45RO-) as well as effector memory CD4+ T cells (CD27-CD45RO+) at weeks 2-6 after ART initiation could distinguish TB-IRIS from non-IRIS individuals. Additional analyses revealed that ART reconstituted different quantities of CD4+ T lymphocyte subsets with preferential expansion of CXCR3+ CCR6- cells in TB-IRIS patients. Moreover, there was an expansion and functional restoration of central memory (CD27+CD45RO+) CXCR3+CCR6- CD4+ lymphocytes and corresponding cytokines, with reduction in CXCR3-CCR6+ cells after ART initiation only in those who developed TB-IRIS. Together, these observations trace a detailed picture of CD4+ T cell subsets tightly associated with IRIS, which may serve as targets for prophylactic and/or therapeutic interventions in the future.engNature ResearchSíndrome Inflamatória da Reconstituição ImuneTuberculoseTuberculose pulmonarHumanosHIVImmune Reconstitution Inflammatory SyndromeTuberculosisPulmonary tuberculosisHumansHIVDifferential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/32172/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMattos P.S.S Differential expression ...2019.pdfMattos 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dc.title.pt_BR.fl_str_mv Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome
title Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome
spellingShingle Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome
Mattos, Paulo Sérgio de Morais da Silveira
Síndrome Inflamatória da Reconstituição Imune
Tuberculose
Tuberculose pulmonar
Humanos
HIV
Immune Reconstitution Inflammatory Syndrome
Tuberculosis
Pulmonary tuberculosis
Humans
HIV
title_short Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome
title_full Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome
title_fullStr Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome
title_full_unstemmed Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome
title_sort Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome
author Mattos, Paulo Sérgio de Morais da Silveira
author_facet Mattos, Paulo Sérgio de Morais da Silveira
Narendran, Gopalan
Akrami, Kevan
Fukutani, Kiyoshi Ferreira
Anbalagan, Selvaraj
Nayak, Kaustuv
Subramanyam, Sudha
Subramani, Rajasekaran
Vinhaes, Caian Leal de Azevedo
Souza, Deivide Oliveira de
Antonelli, Lis Ribeiro do Valle
Satagopan, Kumar
Porter, Brian O
Sher, Alan
Swaminathan, Soumya
Sereti, Irini
Andrade, Bruno de Bezerril
author_role author
author2 Narendran, Gopalan
Akrami, Kevan
Fukutani, Kiyoshi Ferreira
Anbalagan, Selvaraj
Nayak, Kaustuv
Subramanyam, Sudha
Subramani, Rajasekaran
Vinhaes, Caian Leal de Azevedo
Souza, Deivide Oliveira de
Antonelli, Lis Ribeiro do Valle
Satagopan, Kumar
Porter, Brian O
Sher, Alan
Swaminathan, Soumya
Sereti, Irini
Andrade, Bruno de Bezerril
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mattos, Paulo Sérgio de Morais da Silveira
Narendran, Gopalan
Akrami, Kevan
Fukutani, Kiyoshi Ferreira
Anbalagan, Selvaraj
Nayak, Kaustuv
Subramanyam, Sudha
Subramani, Rajasekaran
Vinhaes, Caian Leal de Azevedo
Souza, Deivide Oliveira de
Antonelli, Lis Ribeiro do Valle
Satagopan, Kumar
Porter, Brian O
Sher, Alan
Swaminathan, Soumya
Sereti, Irini
Andrade, Bruno de Bezerril
dc.subject.other.pt_BR.fl_str_mv Síndrome Inflamatória da Reconstituição Imune
Tuberculose
Tuberculose pulmonar
Humanos
HIV
topic Síndrome Inflamatória da Reconstituição Imune
Tuberculose
Tuberculose pulmonar
Humanos
HIV
Immune Reconstitution Inflammatory Syndrome
Tuberculosis
Pulmonary tuberculosis
Humans
HIV
dc.subject.en.pt_BR.fl_str_mv Immune Reconstitution Inflammatory Syndrome
Tuberculosis
Pulmonary tuberculosis
Humans
HIV
description Intramural Research Program of NIAID/NIH and by the Intramuralto- India grant from the US-India Co-operative research program. This study was also financed in part by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (Finance Code 001). The work of B.B.A. was supported by a grant from NIH (U01AI115940). P.S.S.M. was supported by a PhD fellowship from the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). K.F.F. received a fellowship from the Programa Nacional de Pós-Doutorado, CAPES. C.V. and D.S. are supported by FAPESB
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-03-20T13:02:59Z
dc.date.available.fl_str_mv 2019-03-20T13:02:59Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv MATTOS, Paulo Sérgio de Morais da Silveira et al. Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome. Scientific Reports, v. 9, p. 1-9, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32172
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-018-37846-3
identifier_str_mv MATTOS, Paulo Sérgio de Morais da Silveira et al. Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome. Scientific Reports, v. 9, p. 1-9, 2019.
2045-2322
10.1038/s41598-018-37846-3
url https://www.arca.fiocruz.br/handle/icict/32172
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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