MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23657 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil. |
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Cruz, Heidi Lacerda Alves daSilva, Ronaldo Celerino daSegat, LudovicaCarvalho, Márcia Schneider Zuzarte de Mendonça Gomes deBrandão, Lucas André CavalcantiGuimarães, Rafael LimaSantos, Fabiana Cristina FulcoLira, Laís Ariane Siqueira deMontenegro, Lilian Maria LapaSchindler, Haiana CharifkerCrovella, Sergio2017-12-14T12:46:20Z2017-12-14T12:46:20Z2013CRUZ, H. L. A. da et al. MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population. Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, v. 19, p. 323–329, out. 2013.1567-7257https://www.arca.fiocruz.br/handle/icict/2365710.1016/j.meegid.2013.03.002engTuberculoseImunidade inataMBL2PulmonarPolimorfismosTuberculosisInnate immunityMBL2PulmonaryPolymorphismsPredisposição Genética para DoençagenéticaLectina de Ligação a ManosegenéticaAdolescenteAdultoBrasilepidemiologiaEstudos de Casos e ControlesFemininoGenótipoHumanosMasculinoMeia-IdadePolimorfismo de Nucleotídeo ÚnicogenéticaTuberculose PulmonarepidemiologiaTuberculose PulmonargenéticaAdulto JovemMBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil / Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Recife, PE, Brazil.Institute for Maternal and Child Health. Trieste, Italy.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil / Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil.Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Recife, PE, Brazil / Federal University of Pernambuco. Department of Pathology. Recife, PE, Brazil.Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil / Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Recife, PE, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.Institute for Maternal and Child Health. Trieste, Italy.The innate immune system represents the first line of host defense against pathogens. Genetics factors regulating the immune responses play a role in the susceptibility to infectious diseases, such as tuberculosis (TB). We analyzed MBL2 promoter and exon 1 functional single nucleotide polymorphisms (SNPs) in a group of 155TB patients and 148 healthy controls in order to evaluate their influence on the onset of infection and TB development. There was no association between MBL2 -550 HL promoter polymorphisms and susceptibility to develop TB, but heterozygous -221 Y/X genotype was significantly more frequent in pulmonary TB patients than controls. Moreover, MBL2 exon 1 O allele, was significantly associated with susceptibility to TB development in general (p=0.023, OR=1.61, 95% CI 1.05-2.49) and pulmonary TB (p=0.0008, OR=2.16, 95% CI 1.35-3.46); C allele at codon 57, as well as A/C genotype, were significantly more frequent in TB patients than in controls. Our results indicate that MBL2 polymorphisms, especially at codon 57, could be considered as risk factors for TB development.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83092https://www.arca.fiocruz.br/bitstream/icict/23657/1/license.txt447f2497af1ef5cf99b5c07f6fa18dceMD51ORIGINALart. MBL2 gene polymorphisms - cruz.pdfart. MBL2 gene polymorphisms - cruz.pdfapplication/pdf271733https://www.arca.fiocruz.br/bitstream/icict/23657/2/art.%20MBL2%20gene%20polymorphisms%20-%20cruz.pdf2f9b6ce53f099094eda50800d4c5963fMD52TEXTart. 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| dc.title.pt_BR.fl_str_mv |
MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population |
| title |
MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population |
| spellingShingle |
MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population Cruz, Heidi Lacerda Alves da Tuberculose Imunidade inata MBL2 Pulmonar Polimorfismos Tuberculosis Innate immunity MBL2 Pulmonary Polymorphisms Predisposição Genética para Doença genética Lectina de Ligação a Manose genética Adolescente Adulto Brasil epidemiologia Estudos de Casos e Controles Feminino Genótipo Humanos Masculino Meia-Idade Polimorfismo de Nucleotídeo Único genética Tuberculose Pulmonar epidemiologia Tuberculose Pulmonar genética Adulto Jovem |
| title_short |
MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population |
| title_full |
MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population |
| title_fullStr |
MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population |
| title_full_unstemmed |
MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population |
| title_sort |
MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population |
| author |
Cruz, Heidi Lacerda Alves da |
| author_facet |
Cruz, Heidi Lacerda Alves da Silva, Ronaldo Celerino da Segat, Ludovica Carvalho, Márcia Schneider Zuzarte de Mendonça Gomes de Brandão, Lucas André Cavalcanti Guimarães, Rafael Lima Santos, Fabiana Cristina Fulco Lira, Laís Ariane Siqueira de Montenegro, Lilian Maria Lapa Schindler, Haiana Charifker Crovella, Sergio |
| author_role |
author |
| author2 |
Silva, Ronaldo Celerino da Segat, Ludovica Carvalho, Márcia Schneider Zuzarte de Mendonça Gomes de Brandão, Lucas André Cavalcanti Guimarães, Rafael Lima Santos, Fabiana Cristina Fulco Lira, Laís Ariane Siqueira de Montenegro, Lilian Maria Lapa Schindler, Haiana Charifker Crovella, Sergio |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cruz, Heidi Lacerda Alves da Silva, Ronaldo Celerino da Segat, Ludovica Carvalho, Márcia Schneider Zuzarte de Mendonça Gomes de Brandão, Lucas André Cavalcanti Guimarães, Rafael Lima Santos, Fabiana Cristina Fulco Lira, Laís Ariane Siqueira de Montenegro, Lilian Maria Lapa Schindler, Haiana Charifker Crovella, Sergio |
| dc.subject.other.pt_BR.fl_str_mv |
Tuberculose Imunidade inata MBL2 Pulmonar Polimorfismos |
| topic |
Tuberculose Imunidade inata MBL2 Pulmonar Polimorfismos Tuberculosis Innate immunity MBL2 Pulmonary Polymorphisms Predisposição Genética para Doença genética Lectina de Ligação a Manose genética Adolescente Adulto Brasil epidemiologia Estudos de Casos e Controles Feminino Genótipo Humanos Masculino Meia-Idade Polimorfismo de Nucleotídeo Único genética Tuberculose Pulmonar epidemiologia Tuberculose Pulmonar genética Adulto Jovem |
| dc.subject.en.pt_BR.fl_str_mv |
Tuberculosis Innate immunity MBL2 Pulmonary Polymorphisms |
| dc.subject.decs.pt_BR.fl_str_mv |
Predisposição Genética para Doença genética Lectina de Ligação a Manose genética Adolescente Adulto Brasil epidemiologia Estudos de Casos e Controles Feminino Genótipo Humanos Masculino Meia-Idade Polimorfismo de Nucleotídeo Único genética Tuberculose Pulmonar epidemiologia Tuberculose Pulmonar genética Adulto Jovem |
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Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil. |
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2013 |
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2013 |
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2017-12-14T12:46:20Z |
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2017-12-14T12:46:20Z |
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info:eu-repo/semantics/article |
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CRUZ, H. L. A. da et al. MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population. Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, v. 19, p. 323–329, out. 2013. |
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https://www.arca.fiocruz.br/handle/icict/23657 |
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1567-7257 |
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10.1016/j.meegid.2013.03.002 |
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CRUZ, H. L. A. da et al. MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population. Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, v. 19, p. 323–329, out. 2013. 1567-7257 10.1016/j.meegid.2013.03.002 |
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