The Thymus Is a Common Target Organ in Infectious Diseases
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1992 |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/33843 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. |
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Savino, Wilson2019-07-04T15:36:27Z2019-07-04T15:36:27Z1992SAVINO, Wilson. The Thymus Is a Common Target Organ in Infectious Diseases. Plos Pathogens, v. 2, n. 6, p. 1-12, June 2006.1553-7366https://www.arca.fiocruz.br/handle/icict/3384310.1371/journal.ppat.00200621553-7374engPublic Library of ScienceTimoDoenças infeciosasThymusInfectious diseasesThe Thymus Is a Common Target Organ in Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.Infectious disease immunology has largely focused on the effector immune response, changes in the blood and peripheral lymphoid organs of infected individuals, and vaccine development. Studies of the thymus in infected individuals have been neglected, although this is progressively changing. The thymus is a primary lymphoid organ, able to generate mature T cells that eventually colonize secondary lymphoid organs, and is therefore essential for peripheral Tcell renewal. Recent data show that normal thymocyte development and export can be altered as a result of an infectious disease. One common feature is the severe atrophy of the infected organ, mainly due to the apoptosis-related depletion of immature CD4þCD8þ thymocytes. Additionally, thymocyte proliferation is frequently diminished. The microenvironmental compartment of the thymus is also affected, particularly in acute infectious diseases, with a densification of the epithelial network and an increase in the deposition of extracellular matrix. In the murine model of Chagas disease, intrathymic chemokine production is also enhanced, and thymocytes from Trypanosoma cruzi-infected mice exhibit greater numbers of cell migration-related receptors for chemokines and extracellular matrix, as well as increased migratory responses to the corresponding ligands. This profile is correlated with the appearance of potentially autoreactive thymus-derived immature CD4þCD8þ T cells in peripheral organs of infected animals. A variety of infectious agents—including viruses, protozoa, and fungi—invade the thymus, raising the hypothesis of the generation of central immunological tolerance for at least some of the infectious agent-derived antigens. It seems clear that the thymus is targeted in a variety of infections, and that such targeting may have consequences on the behavior of peripheral T lymphocytes. In this context, thymus-centered immunotherapeutic approaches potentially represent a new tool for the treatment of severe infectious diseases.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33843/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWilsonSavino_IOC_1992.pdfWilsonSavino_IOC_1992.pdfapplication/pdf551596https://www.arca.fiocruz.br/bitstream/icict/33843/2/WilsonSavino_IOC_1992.pdf0bcb9265af17b8f8554de6f911b93b68MD52TEXTWilsonSavino_IOC_1992.pdf.txtWilsonSavino_IOC_1992.pdf.txtExtracted texttext/plain65837https://www.arca.fiocruz.br/bitstream/icict/33843/3/WilsonSavino_IOC_1992.pdf.txt483bb56c2b14aca31c91f7f31b08c8ddMD53icict/338432019-07-05 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| dc.title.pt_BR.fl_str_mv |
The Thymus Is a Common Target Organ in Infectious Diseases |
| title |
The Thymus Is a Common Target Organ in Infectious Diseases |
| spellingShingle |
The Thymus Is a Common Target Organ in Infectious Diseases Savino, Wilson Timo Doenças infeciosas Thymus Infectious diseases |
| title_short |
The Thymus Is a Common Target Organ in Infectious Diseases |
| title_full |
The Thymus Is a Common Target Organ in Infectious Diseases |
| title_fullStr |
The Thymus Is a Common Target Organ in Infectious Diseases |
| title_full_unstemmed |
The Thymus Is a Common Target Organ in Infectious Diseases |
| title_sort |
The Thymus Is a Common Target Organ in Infectious Diseases |
| author |
Savino, Wilson |
| author_facet |
Savino, Wilson |
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author |
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Savino, Wilson |
| dc.subject.other.pt_BR.fl_str_mv |
Timo Doenças infeciosas |
| topic |
Timo Doenças infeciosas Thymus Infectious diseases |
| dc.subject.en.pt_BR.fl_str_mv |
Thymus Infectious diseases |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. |
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1992 |
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1992 |
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2019-07-04T15:36:27Z |
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2019-07-04T15:36:27Z |
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SAVINO, Wilson. The Thymus Is a Common Target Organ in Infectious Diseases. Plos Pathogens, v. 2, n. 6, p. 1-12, June 2006. |
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https://www.arca.fiocruz.br/handle/icict/33843 |
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1553-7366 |
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10.1371/journal.ppat.0020062 |
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1553-7374 |
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SAVINO, Wilson. The Thymus Is a Common Target Organ in Infectious Diseases. Plos Pathogens, v. 2, n. 6, p. 1-12, June 2006. 1553-7366 10.1371/journal.ppat.0020062 1553-7374 |
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