Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation

França, Giovanny Vinícius Araújo de; Schuler-Faccini, Lavinia; Oliveira, Wanderson Kleber de; Henriques, Cláudio Maierovitch Pessanha; Carmo, Eduardo Hage; Pedi, Vaneide Daciane; Nunes, Marília L.; Castro, Marcia C.; Serruya, Suzanne Jacob; Silveira, Mariângela F.; Barros, Fernando C.; Victora, Cesar G.

Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation

Detalhes bibliográficos
Autor(a) principal:	França, Giovanny Vinícius Araújo de
Data de Publicação:	2016
Outros Autores:	Schuler-Faccini, Lavinia, Oliveira, Wanderson Kleber de, Henriques, Cláudio Maierovitch Pessanha, Carmo, Eduardo Hage, Pedi, Vaneide Daciane, Nunes, Marília L., Castro, Marcia C., Serruya, Suzanne Jacob, Silveira, Mariângela F., Barros, Fernando C., Victora, Cesar G.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/41268
Resumo:	Claudio M. P. Henriques e Eduardo H. Carmo - Autores vinculados à Fiocruz Brasília, mas não consta a informação no documento.

Metadados do item

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spelling	França, Giovanny Vinícius Araújo deSchuler-Faccini, LaviniaOliveira, Wanderson Kleber deHenriques, Cláudio Maierovitch PessanhaCarmo, Eduardo HagePedi, Vaneide DacianeNunes, Marília L.Castro, Marcia C.Serruya, Suzanne JacobSilveira, Mariângela F.Barros, Fernando C.Victora, Cesar G.2020-05-18T14:53:59Z2020-05-18T14:53:59Z2016FRANÇA, Giovanny V. A. et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet, [New York], v. 388, Aug. 2016.0140-6736https://www.arca.fiocruz.br/handle/icict/4126810.1016/S0140-6736(16)30902-3Claudio M. P. Henriques e Eduardo H. Carmo - Autores vinculados à Fiocruz Brasília, mas não consta a informação no documento.Ministério da Saúde e Organização Pan-Americana da Saúde.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil.Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil.Harvard University. Harvard T H Chan School of Public Health. Boston, MA, USA.Universidade Federal de Pelotas. Programa de Pós-Graduação em Epidemiologia. Pelotas, RS, Brasil.Universidade Católica de Pelotas. Pelotas, RS, Brasil.Universidade Católica de Pelotas. Pelotas, RS, Brasil.Universidade Católica de Pelotas. Pelotas, RS, Brasil.Background In November, 2015, an epidemic of microcephaly was reported in Brazil, which was later attributed to congenital Zika virus infection. 7830 suspected cases had been reported to the Brazilian Ministry of Health by June 4, 2016, but little is known about their characteristics. We aimed to describe these newborn babies in terms of clinical ﬁ ndings, anthropometry, and survival. Methods We reviewed all 1501 liveborn infants for whom investigation by medical teams at State level had been completed as of Feb 27, 2016, and classiﬁ ed suspected cases into ﬁ ve categories based on neuroimaging and laboratory results for Zika virus and other relevant infections. Deﬁ nite cases had laboratory evidence of Zika virus infection; highly probable cases presented speciﬁ c neuroimaging ﬁ ndings, and negative laboratory results for other congenital infections; moderately probable cases had speciﬁ c imaging ﬁ ndings but other infections could not be ruled out; somewhat probable cases had imaging ﬁ ndings, but these were not reported in detail by the local teams; all other newborn babies were classiﬁ ed as discarded cases. Head circumference by gestational age was assessed with InterGrowth standards. First week mortality and history of rash were provided by the State medical teams. Findings Between Nov 19, 2015, and Feb 27, 2015, investigations were completed for 1501 suspected cases reported to the Brazilian Ministry of Health, of whom 899 were discarded. Of the remainder 602 cases, 76 were deﬁ nite, 54 highly probable, 181 moderately probable, and 291 somewhat probable of congenital Zika virus syndrome. Clinical, anthropometric, and survival diﬀ erences were small among the four groups. Compared with these four groups, the 899 discarded cases had larger head circumferences (mean Z scores –1•54 vs –3•13, diﬀ erence 1•58 [95% CI 1•45–1•72]); lower ﬁ rst-week mortality (14 per 1000 vs 51 per 1000; rate ratio 0•28 [95% CI 0•14–0•56]); and were less likely to have a history of rash during pregnancy (20•7% vs 61•4%, ratio 0•34 [95% CI 0•27–0•42]). Rashes in the third trimester of pregnancy were associated with brain abnormalities despite normal sized heads. One in ﬁ ve deﬁ nite or probable cases presented head circumferences in the normal range (above –2 SD below the median of the InterGrowth standard) and for one third of deﬁ nite and probable cases there was no history of a rash during pregnancy. The peak of the epidemic occurred in late November, 2015. Interpretation Zika virus congenital syndrome is a new teratogenic disease. Because many deﬁ nite or probable cases present normal head circumference values and their mothers do not report having a rash, screening criteria must be revised in order to detect all aﬀ ected newborn babies.engElsevierBrazil / epidemiologyCephalometryConfounding Factors, EpidemiologicInfant MortalityMicrocephaly / epidemiologyMicrocephaly / pathologyMicrocephaly / virologyNeonatal Screening / methodsNeuroimagingPregnancyInfant, NewbornPregnancy Complications, Infectious / epidemiologyPregnancy Complications, Infectious / virologyZika Virus / isolation & purificationZika Virus Infection / congenitalZika Virus Infection / diagnosisZika Virus Infection / epidemiologyZika Virus Infection / pathologyZika virus infectionZika virusMicrocephalyInfant newbornEpidemiologyZika virusInfecção por Zika virusMicrocefaliaRecém-NascidoCongenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Giovanny_França_etal.pdfve_Giovanny_França_etal.pdfArtigoapplication/pdf415699https://www.arca.fiocruz.br/bitstream/icict/41268/2/ve_Giovanny_Fran%c3%a7a_etal.pdf9b3eea4445e5ddb437eea3cbbcf37c2eMD52ve_Giovanny_França_etal_Supp.pdfve_Giovanny_França_etal_Supp.pdfMaterial de apoio application/pdf678354https://www.arca.fiocruz.br/bitstream/icict/41268/4/ve_Giovanny_Fran%c3%a7a_etal_Supp.pdff6e5baae72bb7d57be43771146f2715bMD54LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv	Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation
title	Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation
spellingShingle	Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation França, Giovanny Vinícius Araújo de Brazil / epidemiology Cephalometry Confounding Factors, Epidemiologic Infant Mortality Microcephaly / epidemiology Microcephaly / pathology Microcephaly / virology Neonatal Screening / methods Neuroimaging Pregnancy Infant, Newborn Pregnancy Complications, Infectious / epidemiology Pregnancy Complications, Infectious / virology Zika Virus / isolation & purification Zika Virus Infection / congenital Zika Virus Infection / diagnosis Zika Virus Infection / epidemiology Zika Virus Infection / pathology Zika virus infection Zika virus Microcephaly Infant newborn Epidemiology Zika virus Infecção por Zika virus Microcefalia Recém-Nascido
title_short	Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation
title_full	Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation
title_fullStr	Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation
title_full_unstemmed	Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation
title_sort	Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation
author	França, Giovanny Vinícius Araújo de
author_facet	França, Giovanny Vinícius Araújo de Schuler-Faccini, Lavinia Oliveira, Wanderson Kleber de Henriques, Cláudio Maierovitch Pessanha Carmo, Eduardo Hage Pedi, Vaneide Daciane Nunes, Marília L. Castro, Marcia C. Serruya, Suzanne Jacob Silveira, Mariângela F. Barros, Fernando C. Victora, Cesar G.
author_role	author
author2	Schuler-Faccini, Lavinia Oliveira, Wanderson Kleber de Henriques, Cláudio Maierovitch Pessanha Carmo, Eduardo Hage Pedi, Vaneide Daciane Nunes, Marília L. Castro, Marcia C. Serruya, Suzanne Jacob Silveira, Mariângela F. Barros, Fernando C. Victora, Cesar G.
author2_role	author author author author author author author author author author author
dc.contributor.author.fl_str_mv	França, Giovanny Vinícius Araújo de Schuler-Faccini, Lavinia Oliveira, Wanderson Kleber de Henriques, Cláudio Maierovitch Pessanha Carmo, Eduardo Hage Pedi, Vaneide Daciane Nunes, Marília L. Castro, Marcia C. Serruya, Suzanne Jacob Silveira, Mariângela F. Barros, Fernando C. Victora, Cesar G.
dc.subject.mesh.pt_BR.fl_str_mv	Brazil / epidemiology Cephalometry Confounding Factors, Epidemiologic Infant Mortality Microcephaly / epidemiology Microcephaly / pathology Microcephaly / virology Neonatal Screening / methods Neuroimaging Pregnancy Infant, Newborn Pregnancy Complications, Infectious / epidemiology Pregnancy Complications, Infectious / virology Zika Virus / isolation & purification Zika Virus Infection / congenital Zika Virus Infection / diagnosis Zika Virus Infection / epidemiology Zika Virus Infection / pathology
topic	Brazil / epidemiology Cephalometry Confounding Factors, Epidemiologic Infant Mortality Microcephaly / epidemiology Microcephaly / pathology Microcephaly / virology Neonatal Screening / methods Neuroimaging Pregnancy Infant, Newborn Pregnancy Complications, Infectious / epidemiology Pregnancy Complications, Infectious / virology Zika Virus / isolation & purification Zika Virus Infection / congenital Zika Virus Infection / diagnosis Zika Virus Infection / epidemiology Zika Virus Infection / pathology Zika virus infection Zika virus Microcephaly Infant newborn Epidemiology Zika virus Infecção por Zika virus Microcefalia Recém-Nascido
dc.subject.en.pt_BR.fl_str_mv	Zika virus infection Zika virus Microcephaly Infant newborn Epidemiology
dc.subject.decs.pt_BR.fl_str_mv	Zika virus Infecção por Zika virus Microcefalia Recém-Nascido
description	Claudio M. P. Henriques e Eduardo H. Carmo - Autores vinculados à Fiocruz Brasília, mas não consta a informação no documento.
publishDate	2016
dc.date.issued.fl_str_mv	2016
dc.date.accessioned.fl_str_mv	2020-05-18T14:53:59Z
dc.date.available.fl_str_mv	2020-05-18T14:53:59Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	FRANÇA, Giovanny V. A. et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet, [New York], v. 388, Aug. 2016.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/41268
dc.identifier.issn.pt_BR.fl_str_mv	0140-6736
dc.identifier.doi.none.fl_str_mv	10.1016/S0140-6736(16)30902-3
identifier_str_mv	FRANÇA, Giovanny V. A. et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet, [New York], v. 388, Aug. 2016. 0140-6736 10.1016/S0140-6736(16)30902-3
url	https://www.arca.fiocruz.br/handle/icict/41268
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation

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