Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile

Detalhes bibliográficos
Autor(a) principal: Neufeld, Paulo Murillo
Data de Publicação: 2015
Outros Autores: Melhem, Marcia de Souza Carvalho, Szeszs, Maria Walderez, Ribeiro, Marcos Dornelas, Amorim, Efigenia de Lourdes Teixeira, Silva, Manuela da, Lazera, Marcia Dos Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11838
Resumo: Universidade Federal do Rio de Janeiro. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.
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spelling Neufeld, Paulo MurilloMelhem, Marcia de Souza CarvalhoSzeszs, Maria WalderezRibeiro, Marcos DornelasAmorim, Efigenia de Lourdes TeixeiraSilva, Manuela daLazera, Marcia Dos Santos2015-09-28T18:59:21Z2015-09-28T18:59:21Z2015NEUFELD, Paulo Murillo et al. Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile. Braz. J. Microbiol., São Paulo, v. 46, n. 2, p. 477-484, 2015.1678-4405https://www.arca.fiocruz.br/handle/icict/1183810.1590/S1517-838246220120023engSociedade Brasileira de MicrobiologiaCandidaFluconazolAntifúngicosCandidaFluconazoleAntifungal SusceptibilityDisk DiffusionCandidaFluconazolAntifúngicosTestes de Sensibilidade a Antimicrobianos por Disco-DifusãoNosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profileinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.Instituto Adolfo Lutz. Serviço de Parasitologia. São Paulo, SP, Brasil.Instituto Adolfo Lutz. Serviço de Parasitologia. São Paulo, SP, Brasil.Instituto Estadual de Hematologia Arthur da Siqueira Cavalcante. Serviço de Patologia Clínica. Rio de Janeiro, RJ, Brasil.Laboratório Sérgio Franco. Setor de Microbiologia e Urinálise. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Hospital Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.One hundred and forty-one Candida species isolated from clinical specimens of hospitalized patients in Rio de Janeiro, Brazil, during 2002 to 2007, were analized in order to evaluate the distribution and susceptibility of these species to fluconazole. Candida albicans was the most frequent species (45.4%), followed byC. parapsilosis sensu lato (28.4%), C. tropicalis (14.2%), C. guilliermondii (6.4%),C. famata (2.8%), C. glabrata (1.4%), C. krusei (0.7%) and C. lambica (0.7%). The sources of fungal isolates were blood (47.5%), respiratory tract (17.7%), urinary tract (16.3%), skin and mu-cous membrane (7.1%), catheter (5.6%), feces (2.1%) and mitral valve tissue (0.7%). The susceptibility test was performed using the methodology of disk-diffusion in agar as recommended in theM44-A2 Document of the Clinical and Laboratory Standards Institute (CLSI). The majority of the clinical isolates (97.2%) was susceptible (S) to fluconazole, although three isolates (2.1%) were susceptible-dose dependent (S-DD) and one of them (0.7%) was resistant (R). The S-DD isolates were C. albicans, C. parapsilosis sensu lato and C. tropicalis. One isolate of C. krusei was resistant to fluconazole. This work documents the high susceptibility to fluconazole by Candida species isolated in Rio de Janeiro, Brazil.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11838/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINAL1517-8382-bjm-46-2-477.pdf1517-8382-bjm-46-2-477.pdfapplication/pdf457338https://www.arca.fiocruz.br/bitstream/icict/11838/2/1517-8382-bjm-46-2-477.pdff1ec177213d8d3445ad6c49d5d3eb04aMD52TEXT1517-8382-bjm-46-2-477.pdf.txt1517-8382-bjm-46-2-477.pdf.txtExtracted texttext/plain34841https://www.arca.fiocruz.br/bitstream/icict/11838/3/1517-8382-bjm-46-2-477.pdf.txt5044094cf568be3705e49af2b27b50fdMD53icict/118382019-08-13 14:52:28.222oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-08-13T17:52:28Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile
title Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile
spellingShingle Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile
Neufeld, Paulo Murillo
Candida
Fluconazol
Antifúngicos
Candida
Fluconazole
Antifungal Susceptibility
Disk Diffusion
Candida
Fluconazol
Antifúngicos
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
title_short Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile
title_full Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile
title_fullStr Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile
title_full_unstemmed Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile
title_sort Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile
author Neufeld, Paulo Murillo
author_facet Neufeld, Paulo Murillo
Melhem, Marcia de Souza Carvalho
Szeszs, Maria Walderez
Ribeiro, Marcos Dornelas
Amorim, Efigenia de Lourdes Teixeira
Silva, Manuela da
Lazera, Marcia Dos Santos
author_role author
author2 Melhem, Marcia de Souza Carvalho
Szeszs, Maria Walderez
Ribeiro, Marcos Dornelas
Amorim, Efigenia de Lourdes Teixeira
Silva, Manuela da
Lazera, Marcia Dos Santos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Neufeld, Paulo Murillo
Melhem, Marcia de Souza Carvalho
Szeszs, Maria Walderez
Ribeiro, Marcos Dornelas
Amorim, Efigenia de Lourdes Teixeira
Silva, Manuela da
Lazera, Marcia Dos Santos
dc.subject.other.pt_BR.fl_str_mv Candida
Fluconazol
Antifúngicos
topic Candida
Fluconazol
Antifúngicos
Candida
Fluconazole
Antifungal Susceptibility
Disk Diffusion
Candida
Fluconazol
Antifúngicos
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
dc.subject.en.pt_BR.fl_str_mv Candida
Fluconazole
Antifungal Susceptibility
Disk Diffusion
dc.subject.decs.pt_BR.fl_str_mv Candida
Fluconazol
Antifúngicos
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
description Universidade Federal do Rio de Janeiro. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-09-28T18:59:21Z
dc.date.available.fl_str_mv 2015-09-28T18:59:21Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NEUFELD, Paulo Murillo et al. Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile. Braz. J. Microbiol., São Paulo, v. 46, n. 2, p. 477-484, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11838
dc.identifier.issn.none.fl_str_mv 1678-4405
dc.identifier.doi.none.fl_str_mv 10.1590/S1517-838246220120023
identifier_str_mv NEUFELD, Paulo Murillo et al. Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile. Braz. J. Microbiol., São Paulo, v. 46, n. 2, p. 477-484, 2015.
1678-4405
10.1590/S1517-838246220120023
url https://www.arca.fiocruz.br/handle/icict/11838
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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