Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44427 |
Resumo: | a Department of Pharmaceutical Sciences, Federal University of Pernambuco- UFPE, Recife, PE, Brazil b Department of Pharmacy, Federal University of Ceara´- UFC, Fortaleza, CE, Brazil c Department of Biological Sciences, Regional University of Cariri- URCA, Crato, CE, Brazil d Department of Biological Chemistry, Regional University of Cariri- URCA, Crato, CE, Brazil e Faculty of Medicine of Juazeiro do Norte- Esta´cio FMJ, Juazeiro do Norte- CE, Brazil f Department of Pharmacy, Federal University of Paraíba- UFPB, Joa˜o Pessoa, PB, Brazil g Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil h Department of Antibiotics, Federal University of Pernambuco- UFPE, Recife, PE, Brazil |
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Bezerra, Camila FonsecaAlencar Júnior, José Geraldo deHonorato, Rosilaine de LimaSantos, Antonia Thassya Lucas dosSilva, Josefa Carolaine Pereira daSilva, Taís Gusmão daLeal, Antonio Linkoln Alves BorgesRocha, Janaína EsmeraldoFreitas, Thiago Sampaio deVieira, Thiago Adler TavarresBezerra, Maria Clara FonsecaSales, Debora LimaKerntopf, Marta ReginaDelmondes, Gyllyandeson de AraujoBarbosa Filho, José MariaPeixoto, Laisla RangelPinheiro, Allyson PontesRibeiro Filho, JaimeCoutinho, Henrique Douglas MeloBraga, Maria Flaviana Bezerra MoraisSilva, Teresinha Gonçalves da2020-11-16T11:53:54Z2020-11-16T11:53:54Z2020BEZERRA, Camila Fonseca et al. Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole. Chemistry and Physics of Lipids, v. 233, 2020.0009-3084https://www.arca.fiocruz.br/handle/icict/4442710.1016/j.chemphyslip.2020.104987a Department of Pharmaceutical Sciences, Federal University of Pernambuco- UFPE, Recife, PE, Brazil b Department of Pharmacy, Federal University of Ceara´- UFC, Fortaleza, CE, Brazil c Department of Biological Sciences, Regional University of Cariri- URCA, Crato, CE, Brazil d Department of Biological Chemistry, Regional University of Cariri- URCA, Crato, CE, Brazil e Faculty of Medicine of Juazeiro do Norte- Esta´cio FMJ, Juazeiro do Norte- CE, Brazil f Department of Pharmacy, Federal University of Paraíba- UFPB, Joa˜o Pessoa, PB, Brazil g Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil h Department of Antibiotics, Federal University of Pernambuco- UFPE, Recife, PE, Brazil"Múltipla – ver em notas”Candida infections represent a threat to human health. Candida albicans is the main causative agent of invasive candidiasis, especially in immunosuppressed patients. The emergence of resistant strains has required the development of new therapeutic strategies. In this context, the use of liposomes as drug carrier systems is a promising alternative in drug development. Thus, considering the evidence demonstrating that sesquiterpene farnesol is a bioactive compound with antifungal properties, this study evaluated the activity farnesol-containing liposomes against different Candida strains. The IC50 of farnesol and its liposomal formulation was assessed in vitro using cultures of Candida albicans, Candida tropicalis, and Candida krusei. The Minimum Fungicidal Con- centration (MFC) was established by subculture in solid medium. The occurrence of fungal dimorphism was analyzed using optical microscopy. The effects on antifungal resistance to fluconazole were assessed by evalu- ating the impact of combined therapy on the growth of Candida strains. The characterization of liposomes was carried out considering their vesicular size, polydispersion index, and zeta medium potential, in addition to electron microscopy analysis. Farnesol exerted an antifungal activity that might be associated with the inhibition of fungal dimorphism, especially in Candida albicans. The incorporation of farnesol into liposomes significantly increased its antifungal activity against C. albicans, C. tropicalis, and C. krusei. In addition, liposomal farnesol potentiated the action of fluconazole against C. albicans and C. tropicalis. On the other hand, the association of unconjugated farnesol with fluconazole resulted in antagonistic effects. In conclusion, farnesol-containing li- posomes have the potential to be used in antifungal drug development. However, further research is required to investigate how the antifungal properties of farnesol are affected by the interaction with liposomes, contributing to the modulation of antifungal resistance to conventional drugs.engElsevierFarnesolLipossomasFluconazolCandidaAnticorpos AntifúngicosFarnesolLiposomesFluconazoleCandida dimorphismAntifungal effectAntifungal activity of farnesol incorporated in liposomes and associated with fluconazoleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/44427/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALBezerra, C.F. Antifungal activity....pdfBezerra, C.F. 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| dc.title.pt_BR.fl_str_mv |
Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole |
| title |
Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole |
| spellingShingle |
Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole Bezerra, Camila Fonseca Farnesol Lipossomas Fluconazol Candida Anticorpos Antifúngicos Farnesol Liposomes Fluconazole Candida dimorphism Antifungal effect |
| title_short |
Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole |
| title_full |
Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole |
| title_fullStr |
Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole |
| title_full_unstemmed |
Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole |
| title_sort |
Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole |
| author |
Bezerra, Camila Fonseca |
| author_facet |
Bezerra, Camila Fonseca Alencar Júnior, José Geraldo de Honorato, Rosilaine de Lima Santos, Antonia Thassya Lucas dos Silva, Josefa Carolaine Pereira da Silva, Taís Gusmão da Leal, Antonio Linkoln Alves Borges Rocha, Janaína Esmeraldo Freitas, Thiago Sampaio de Vieira, Thiago Adler Tavarres Bezerra, Maria Clara Fonseca Sales, Debora Lima Kerntopf, Marta Regina Delmondes, Gyllyandeson de Araujo Barbosa Filho, José Maria Peixoto, Laisla Rangel Pinheiro, Allyson Pontes Ribeiro Filho, Jaime Coutinho, Henrique Douglas Melo Braga, Maria Flaviana Bezerra Morais Silva, Teresinha Gonçalves da |
| author_role |
author |
| author2 |
Alencar Júnior, José Geraldo de Honorato, Rosilaine de Lima Santos, Antonia Thassya Lucas dos Silva, Josefa Carolaine Pereira da Silva, Taís Gusmão da Leal, Antonio Linkoln Alves Borges Rocha, Janaína Esmeraldo Freitas, Thiago Sampaio de Vieira, Thiago Adler Tavarres Bezerra, Maria Clara Fonseca Sales, Debora Lima Kerntopf, Marta Regina Delmondes, Gyllyandeson de Araujo Barbosa Filho, José Maria Peixoto, Laisla Rangel Pinheiro, Allyson Pontes Ribeiro Filho, Jaime Coutinho, Henrique Douglas Melo Braga, Maria Flaviana Bezerra Morais Silva, Teresinha Gonçalves da |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bezerra, Camila Fonseca Alencar Júnior, José Geraldo de Honorato, Rosilaine de Lima Santos, Antonia Thassya Lucas dos Silva, Josefa Carolaine Pereira da Silva, Taís Gusmão da Leal, Antonio Linkoln Alves Borges Rocha, Janaína Esmeraldo Freitas, Thiago Sampaio de Vieira, Thiago Adler Tavarres Bezerra, Maria Clara Fonseca Sales, Debora Lima Kerntopf, Marta Regina Delmondes, Gyllyandeson de Araujo Barbosa Filho, José Maria Peixoto, Laisla Rangel Pinheiro, Allyson Pontes Ribeiro Filho, Jaime Coutinho, Henrique Douglas Melo Braga, Maria Flaviana Bezerra Morais Silva, Teresinha Gonçalves da |
| dc.subject.other.pt_BR.fl_str_mv |
Farnesol Lipossomas Fluconazol Candida Anticorpos Antifúngicos |
| topic |
Farnesol Lipossomas Fluconazol Candida Anticorpos Antifúngicos Farnesol Liposomes Fluconazole Candida dimorphism Antifungal effect |
| dc.subject.en.pt_BR.fl_str_mv |
Farnesol Liposomes Fluconazole Candida dimorphism Antifungal effect |
| description |
a Department of Pharmaceutical Sciences, Federal University of Pernambuco- UFPE, Recife, PE, Brazil b Department of Pharmacy, Federal University of Ceara´- UFC, Fortaleza, CE, Brazil c Department of Biological Sciences, Regional University of Cariri- URCA, Crato, CE, Brazil d Department of Biological Chemistry, Regional University of Cariri- URCA, Crato, CE, Brazil e Faculty of Medicine of Juazeiro do Norte- Esta´cio FMJ, Juazeiro do Norte- CE, Brazil f Department of Pharmacy, Federal University of Paraíba- UFPB, Joa˜o Pessoa, PB, Brazil g Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil h Department of Antibiotics, Federal University of Pernambuco- UFPE, Recife, PE, Brazil |
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2020 |
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2020-11-16T11:53:54Z |
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2020-11-16T11:53:54Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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BEZERRA, Camila Fonseca et al. Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole. Chemistry and Physics of Lipids, v. 233, 2020. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/44427 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0009-3084 |
| dc.identifier.eissn.none.fl_str_mv |
10.1016/j.chemphyslip.2020.104987 |
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BEZERRA, Camila Fonseca et al. Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole. Chemistry and Physics of Lipids, v. 233, 2020. 0009-3084 10.1016/j.chemphyslip.2020.104987 |
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https://www.arca.fiocruz.br/handle/icict/44427 |
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eng |
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openAccess |
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Elsevier |
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Elsevier |
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