Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/43562 |
Resumo: | Jaime Ribeiro-Filho. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. 1 Department of Pharmaceutical Sciences, Federal University of Pernambuco-UFPE, Recife-PE 50670-901, Brazil; camilawasidi@gmail.com 2 Department of Pharmacy, Federal University of Ceará-UFC, Fortaleza-CE 60020-181, Brazil; junioralencar727@gmail.com 3 Department of Biological Sciences, Regional University of Cariri-URCA, Crato-CE 63105-010, Brazil; rosilainehonorato@gmail.com (R.d.L.H.); thassyalucas@hotmail.com (A.T.L.d.S.); carol.bio1881@outlook.com (J.C.P.d.S.); taisgusmao96@gmail.com (T.G.d.S.); allysson.ponheiro@urca.br (A.P.P.); flavianamoraisb@yahoo.com.br (M.F.B.M.-B.) 4 Department of Biological Chemistry, Regional University of Cariri-URCA, Crato-CE 63105-010, Brazil; antoniolinkoln@hotmail.com (A.L.A.B.L.); thiagocrato@hotmail.com (T.S.d.F.); thiago.a.t.vieira@gmail.com (T.A.T.V.); janainaesmeraldo@gmail.com (J.E.R.); debora.lima.sales@gmail.com (D.L.S.) 5 Department of Pharmacy, Federal University of Paraíba-UFPB, João Pessoa-PB 58051-900, Brazil; jbarbosa@ltf.ufpb.br (J.M.B.F.); grsousafarm@gmail.com (G.R.d.S.) 6 Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador-BA 40296-710, Brazil; jaimeribeirofilho@gmail.com 7 Departament of Antibiotics, Federal University of Pernambuco-UFPE, Recife-PE 50670-901, Brazil; teresinha100@gmail.com |
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Bezerra, Camila FonsecaAlencar Júnior, José Geraldo deHonorato, Rosilaine de LimaSantos, Antonia Thassya Lucas dosSilva, Josefa Carolaine Pereira daSilva, Taís Gusmão daLeal, Antonio Linkoln Alves BorgesFreitas, Thiago Sampaio deVieira, Thiago Adler TavaresRocha, Janaína EsmeraldoSales, Debora LimaBarbosa Filho, José MariaSousa, Gabriela Ribeiro dePinheiro, Allyson PontesRibeiro Filho, JaimeCoutinho, Henrique Douglas MeloBraga, Maria Flaviana Bezerra MoraisSilva, Teresinha Gonçalves da2020-09-23T11:54:40Z2020-09-23T11:54:40Z2020BEZERRA, Camila Fonseca et al. Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole. Membranes, 2020.2077-0375https://www.arca.fiocruz.br/handle/icict/43562Jaime Ribeiro-Filho. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. 1 Department of Pharmaceutical Sciences, Federal University of Pernambuco-UFPE, Recife-PE 50670-901, Brazil; camilawasidi@gmail.com 2 Department of Pharmacy, Federal University of Ceará-UFC, Fortaleza-CE 60020-181, Brazil; junioralencar727@gmail.com 3 Department of Biological Sciences, Regional University of Cariri-URCA, Crato-CE 63105-010, Brazil; rosilainehonorato@gmail.com (R.d.L.H.); thassyalucas@hotmail.com (A.T.L.d.S.); carol.bio1881@outlook.com (J.C.P.d.S.); taisgusmao96@gmail.com (T.G.d.S.); allysson.ponheiro@urca.br (A.P.P.); flavianamoraisb@yahoo.com.br (M.F.B.M.-B.) 4 Department of Biological Chemistry, Regional University of Cariri-URCA, Crato-CE 63105-010, Brazil; antoniolinkoln@hotmail.com (A.L.A.B.L.); thiagocrato@hotmail.com (T.S.d.F.); thiago.a.t.vieira@gmail.com (T.A.T.V.); janainaesmeraldo@gmail.com (J.E.R.); debora.lima.sales@gmail.com (D.L.S.) 5 Department of Pharmacy, Federal University of Paraíba-UFPB, João Pessoa-PB 58051-900, Brazil; jbarbosa@ltf.ufpb.br (J.M.B.F.); grsousafarm@gmail.com (G.R.d.S.) 6 Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador-BA 40296-710, Brazil; jaimeribeirofilho@gmail.com 7 Departament of Antibiotics, Federal University of Pernambuco-UFPE, Recife-PE 50670-901, Brazil; teresinha100@gmail.comNational Council for Scientific Development and Technological (CNPq) and the Coordination for the Improvement of Level Personnel Superior (CAPES), for supporting the work.“Múltipla – ver em notas”Background: Infections by Candida species represent a serious threat to the health of immunocompromised individuals. Evidence has indicated that nerolidol has significant antifungal properties. Nonetheless, its use is restricted due to a low water solubility and high photosensitivity. The incorporation into liposomes may represent an e cient alternative to improve the physicochemical and biopharmaceutical properties of this compound. The present study aimed to characterize the antifungal properties of liposomal nerolidol, alone or in combination with fluconazole. Of note, this is the first study reporting the antifungal activity of liposomal nerolidol and its potentiating e ect in association with fluconazole. (2) Methods: The Inhibitory Concentration 50%-IC50 and minimum fungicide concentrations (MFC) of the substances against Candida albicans (CA), Candida tropicalis (CT), and Candida krusei (CK) were established by subculture in a solid medium. To evaluate the antifungal-enhancing e ect, the MFC of fluconazole was determined in the presence or absence of subinhibitory concentrations of nerolidol (free or liposomal). The analysis of fungal dimorphism was performed through optical microscopy and the characterization of liposomes was carried out considering the vesicular size, polydispersion index, and zeta medium potential, in addition to a scanning electron microscopy analysis. (3) Results: The physicochemical characterization revealed that liposomes were obtained as homogenous populations of spherical vesicles. The data obtained in the present study indicate that nerolidol acts as an antifungal agent against Candida albicans and Candida tropicalis, in addition to potentiating (only in the liposomal form) the e ect of fluconazole. However, the compound had little inhibitory e ect on fungal dimorphism. (4) Conclusions: The incorporation of nerolidol into liposomes improved its antifungal-modulating properties.engMDPILipossomasFluconazolCandidaAnticorpos AntifúngicosNerolidolLiposomesFluconazoleCandida dimorphismAntifungal resistance inhibitionAntifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazoleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43562/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBezerra, Camila Fonseca Antifungal....pdfBezerra, Camila Fonseca Antifungal....pdfapplication/pdf1776537https://www.arca.fiocruz.br/bitstream/icict/43562/2/Bezerra%2c%20Camila%20Fonseca%20Antifungal....pdf5b7931b377eff165c0ccd7b071562732MD52TEXTBezerra, Camila Fonseca 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| dc.title.pt_BR.fl_str_mv |
Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole |
| title |
Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole |
| spellingShingle |
Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole Bezerra, Camila Fonseca Lipossomas Fluconazol Candida Anticorpos Antifúngicos Nerolidol Liposomes Fluconazole Candida dimorphism Antifungal resistance inhibition |
| title_short |
Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole |
| title_full |
Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole |
| title_fullStr |
Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole |
| title_full_unstemmed |
Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole |
| title_sort |
Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole |
| author |
Bezerra, Camila Fonseca |
| author_facet |
Bezerra, Camila Fonseca Alencar Júnior, José Geraldo de Honorato, Rosilaine de Lima Santos, Antonia Thassya Lucas dos Silva, Josefa Carolaine Pereira da Silva, Taís Gusmão da Leal, Antonio Linkoln Alves Borges Freitas, Thiago Sampaio de Vieira, Thiago Adler Tavares Rocha, Janaína Esmeraldo Sales, Debora Lima Barbosa Filho, José Maria Sousa, Gabriela Ribeiro de Pinheiro, Allyson Pontes Ribeiro Filho, Jaime Coutinho, Henrique Douglas Melo Braga, Maria Flaviana Bezerra Morais Silva, Teresinha Gonçalves da |
| author_role |
author |
| author2 |
Alencar Júnior, José Geraldo de Honorato, Rosilaine de Lima Santos, Antonia Thassya Lucas dos Silva, Josefa Carolaine Pereira da Silva, Taís Gusmão da Leal, Antonio Linkoln Alves Borges Freitas, Thiago Sampaio de Vieira, Thiago Adler Tavares Rocha, Janaína Esmeraldo Sales, Debora Lima Barbosa Filho, José Maria Sousa, Gabriela Ribeiro de Pinheiro, Allyson Pontes Ribeiro Filho, Jaime Coutinho, Henrique Douglas Melo Braga, Maria Flaviana Bezerra Morais Silva, Teresinha Gonçalves da |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bezerra, Camila Fonseca Alencar Júnior, José Geraldo de Honorato, Rosilaine de Lima Santos, Antonia Thassya Lucas dos Silva, Josefa Carolaine Pereira da Silva, Taís Gusmão da Leal, Antonio Linkoln Alves Borges Freitas, Thiago Sampaio de Vieira, Thiago Adler Tavares Rocha, Janaína Esmeraldo Sales, Debora Lima Barbosa Filho, José Maria Sousa, Gabriela Ribeiro de Pinheiro, Allyson Pontes Ribeiro Filho, Jaime Coutinho, Henrique Douglas Melo Braga, Maria Flaviana Bezerra Morais Silva, Teresinha Gonçalves da |
| dc.subject.other.pt_BR.fl_str_mv |
Lipossomas Fluconazol Candida Anticorpos Antifúngicos |
| topic |
Lipossomas Fluconazol Candida Anticorpos Antifúngicos Nerolidol Liposomes Fluconazole Candida dimorphism Antifungal resistance inhibition |
| dc.subject.en.pt_BR.fl_str_mv |
Nerolidol Liposomes Fluconazole Candida dimorphism Antifungal resistance inhibition |
| description |
Jaime Ribeiro-Filho. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. 1 Department of Pharmaceutical Sciences, Federal University of Pernambuco-UFPE, Recife-PE 50670-901, Brazil; camilawasidi@gmail.com 2 Department of Pharmacy, Federal University of Ceará-UFC, Fortaleza-CE 60020-181, Brazil; junioralencar727@gmail.com 3 Department of Biological Sciences, Regional University of Cariri-URCA, Crato-CE 63105-010, Brazil; rosilainehonorato@gmail.com (R.d.L.H.); thassyalucas@hotmail.com (A.T.L.d.S.); carol.bio1881@outlook.com (J.C.P.d.S.); taisgusmao96@gmail.com (T.G.d.S.); allysson.ponheiro@urca.br (A.P.P.); flavianamoraisb@yahoo.com.br (M.F.B.M.-B.) 4 Department of Biological Chemistry, Regional University of Cariri-URCA, Crato-CE 63105-010, Brazil; antoniolinkoln@hotmail.com (A.L.A.B.L.); thiagocrato@hotmail.com (T.S.d.F.); thiago.a.t.vieira@gmail.com (T.A.T.V.); janainaesmeraldo@gmail.com (J.E.R.); debora.lima.sales@gmail.com (D.L.S.) 5 Department of Pharmacy, Federal University of Paraíba-UFPB, João Pessoa-PB 58051-900, Brazil; jbarbosa@ltf.ufpb.br (J.M.B.F.); grsousafarm@gmail.com (G.R.d.S.) 6 Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador-BA 40296-710, Brazil; jaimeribeirofilho@gmail.com 7 Departament of Antibiotics, Federal University of Pernambuco-UFPE, Recife-PE 50670-901, Brazil; teresinha100@gmail.com |
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2020-09-23T11:54:40Z |
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2020 |
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BEZERRA, Camila Fonseca et al. Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole. Membranes, 2020. |
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https://www.arca.fiocruz.br/handle/icict/43562 |
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2077-0375 |
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BEZERRA, Camila Fonseca et al. Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole. Membranes, 2020. 2077-0375 |
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