Adult worm-specific IgE/IgG4 balance is associated with low infection levels of Schistosoma mansoni in an endemic area

Detalhes bibliográficos
Autor(a) principal: Figueiredo, Joanemile Pacheco de
Data de Publicação: 2012
Outros Autores: Oliveira, Ricardo Riccio, Cardoso, Luciana Santos, Barnes, K. C, Grant, A. V, Carvalho Filho, Edgar Marcelino, Araujo, Maria Ilma Andrade Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27373
Resumo: Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Figueiredo, Joanemile Pacheco deOliveira, Ricardo RiccioCardoso, Luciana SantosBarnes, K. CGrant, A. VCarvalho Filho, Edgar MarcelinoAraujo, Maria Ilma Andrade Santos2018-07-09T19:06:11Z2018-07-09T19:06:11Z2012FIGUEIREDO, J. P. et al. Adult worm-specific IgE/IgG4 balance is associated with low infection levels of Schistosoma mansoni in an endemic area. Parasite Immunology, v. 34, p, 604–610, 2012.0141-9838https://www.arca.fiocruz.br/handle/icict/2737310.1111/pim.12001Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Mary Beryl Patch Turnbull Scholar Program. MIA and EMC are investigators supported by National Council for Scientific and Technological Development (CNPq).Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farm cia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil / Universidade do Estado da Bahia. Salvador, BA, BrasilJohns Hopkins University. Department of Medicine. Division of Allergy and Clinical Immunology. Baltimore, MD, USAInstitut National de la Sant et de la Recherche Medicale Laboratory of Human Genetics of Infectious Diseases. Paris, France / University Paris Descartes. Necker Medical School. Paris, FranceUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilField studies have suggested an immune-mediated mechanism associated with resistance to Schistosoma mansoni infection. Overall, levels of specific IgE have been correlated with resistance to infection, whereas levels of IgG4 have been associated with susceptibility. This study aimed to evaluate serum levels of soluble adult worm antigen preparation (SWAP)-specific IgE and IgG4 in relation to current infection in a large casuistic of individuals living in an endemic area of schistosomiasis in Bahia, Brazil. The prevalence of S. mansoni infection was 37·7% and the mean parasite burden was 55·4 (0-2100) epg/faeces. There was no significant difference in the levels of SWAP-specific IgE in individuals with different parasite burden, whereas high producers of parasite-specific IgG4 presented higher parasite burden when compared to low IgG4 producers. Additionally, S. mansoni parasite load was positively correlated with the levels of specific IgG4 or total IgE. No significant correlation was observed between parasite burden and SWAP-specific IgE. Nevertheless, SWAP-specific IgE/IgG4 ratio was higher in uninfected or lightly infected individuals (1-99 epg/faeces) than in heavily infected ones (≥400 epg/feces). These findings highlight the important role of IgE/IgG4 ratio in the resistance to infection, which could be useful for further studies in schistosomiasis vaccine candidates.engWileyHelmintosIgEIgG4Schistosoma mansoniHelminthIgEIgG4Schistosoma mansoniAdult worm-specific IgE/IgG4 balance is associated with low infection levels of Schistosoma mansoni in an endemic areainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27373/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFigueiredo JP Adult worm-specific IgE IgG4 balance ....pdfFigueiredo JP Adult worm-specific IgE IgG4 balance 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dc.title.pt_BR.fl_str_mv Adult worm-specific IgE/IgG4 balance is associated with low infection levels of Schistosoma mansoni in an endemic area
title Adult worm-specific IgE/IgG4 balance is associated with low infection levels of Schistosoma mansoni in an endemic area
spellingShingle Adult worm-specific IgE/IgG4 balance is associated with low infection levels of Schistosoma mansoni in an endemic area
Figueiredo, Joanemile Pacheco de
Helmintos
IgE
IgG4
Schistosoma mansoni
Helminth
IgE
IgG4
Schistosoma mansoni
title_short Adult worm-specific IgE/IgG4 balance is associated with low infection levels of Schistosoma mansoni in an endemic area
title_full Adult worm-specific IgE/IgG4 balance is associated with low infection levels of Schistosoma mansoni in an endemic area
title_fullStr Adult worm-specific IgE/IgG4 balance is associated with low infection levels of Schistosoma mansoni in an endemic area
title_full_unstemmed Adult worm-specific IgE/IgG4 balance is associated with low infection levels of Schistosoma mansoni in an endemic area
title_sort Adult worm-specific IgE/IgG4 balance is associated with low infection levels of Schistosoma mansoni in an endemic area
author Figueiredo, Joanemile Pacheco de
author_facet Figueiredo, Joanemile Pacheco de
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
Barnes, K. C
Grant, A. V
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma Andrade Santos
author_role author
author2 Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
Barnes, K. C
Grant, A. V
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma Andrade Santos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Figueiredo, Joanemile Pacheco de
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
Barnes, K. C
Grant, A. V
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma Andrade Santos
dc.subject.other.pt_BR.fl_str_mv Helmintos
IgE
IgG4
Schistosoma mansoni
topic Helmintos
IgE
IgG4
Schistosoma mansoni
Helminth
IgE
IgG4
Schistosoma mansoni
dc.subject.en.pt_BR.fl_str_mv Helminth
IgE
IgG4
Schistosoma mansoni
description Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2018-07-09T19:06:11Z
dc.date.available.fl_str_mv 2018-07-09T19:06:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FIGUEIREDO, J. P. et al. Adult worm-specific IgE/IgG4 balance is associated with low infection levels of Schistosoma mansoni in an endemic area. Parasite Immunology, v. 34, p, 604–610, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27373
dc.identifier.issn.pt_BR.fl_str_mv 0141-9838
dc.identifier.doi.none.fl_str_mv 10.1111/pim.12001
identifier_str_mv FIGUEIREDO, J. P. et al. Adult worm-specific IgE/IgG4 balance is associated with low infection levels of Schistosoma mansoni in an endemic area. Parasite Immunology, v. 34, p, 604–610, 2012.
0141-9838
10.1111/pim.12001
url https://www.arca.fiocruz.br/handle/icict/27373
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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