Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil

Detalhes bibliográficos
Autor(a) principal: Oliveira-Filho, Edmilson Ferreira de
Data de Publicação: 2019
Outros Autores: Santos, Debora R. l. dos, Durães-Carvalho, Ricardo, Silva, Adalúcia da, Lima, Gustavo Barbosa de, Batista Filho, Antônio Fernando B., Pena, Lindomar J., Gil, Laura H.V. G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/0074-02760180585
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35956
Resumo: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil / Charité-Universitätsmedizin Berlin. Berlin Institute of Health. Institute of Virology. Berlin, Germany.
id CRUZ_2c9c20c92f3635d1bd8d0e3e33e27af0
oai_identifier_str oai:www.arca.fiocruz.br:icict/35956
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Oliveira-Filho, Edmilson Ferreira deSantos, Debora R. l. dosDurães-Carvalho, RicardoSilva, Adalúcia daLima, Gustavo Barbosa deBatista Filho, Antônio Fernando B.Pena, Lindomar J.Gil, Laura H.V. G.2019-09-27T13:48:14Z2019-09-27T13:48:14Z2019OLIVEIRA-FILHO, Edmilson Ferreira de et al. Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-5, 2019.0074-0276https://www.arca.fiocruz.br/handle/icict/3595610.1590/0074-02760180585engEvolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil / Charité-Universitätsmedizin Berlin. Berlin Institute of Health. Institute of Virology. Berlin, Germany.Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil.Universidade Federal Rural de Pernambuco. Departamento de Medicina Veterinária. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.Hepatitis E virus (HEV), an emerging virus associated with acute hepatic disease, leads to thousands of deaths worldwide. HEV has already been reported in Brazil; however, there is a lack of epidemiological and molecular information on the genetic variability, taxonomy, and evolution of HEV. It is thus unclear whether hepatitis E is a neglected disease in Brazil or it has low relevance for public health in this country. Here, for the first time, we report the presence of HEV in Northeast Brazil. A total of 119 swine faecal samples were screened for the presence of HEV RNA using real-time polymerase chain reaction (RT-PCR) and further confirmed by conventional RT-PCR; among these, two samples were identified as positive. Molecular evolution analyses based on capsid sequences revealed that the samples had close proximities to HEV sequences belonging to genotype 3 and were genetically related to subtype 3f isolated in humans. Parsimony ancestral states analysis indicated gene flow events from HEV cross-species infection, suggesting an important role of pig hosts in viral spillover. HEV's ability for zoonotic transmission by inter-species host switching as well as its possible adaptation to new animal species remain important issues for human health.Zoonotic hepatitis E virusSwineGenotype 3AnimaisBrasilCapsídeoVirologiaFezesGenótipoHepatite EVírus da Hepatite EGenéticaIsolamento & purificaçãoHumanosFilogeniaRNA ViralReação em Cadeia da Polimerase em Tempo RealAnálise de Sequência de DNASuínosDoenças dos SuínosTransmissãoZoonosesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83085https://www.arca.fiocruz.br/bitstream/icict/35956/1/license.txt4194663c61da82c21746deb8d6361188MD51ORIGINALEvolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil..pdfEvolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil..pdfapplication/pdf1548800https://www.arca.fiocruz.br/bitstream/icict/35956/2/Evolutionary%20study%20of%20potentially%20zoonotic%20hepatitis%20E%20virus%20genotype%203%20from%20swine%20in%20Northeast%20Brazil..pdf2a9dce848f940d9c83c57a7209deddb1MD52TEXTEvolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil..pdf.txtEvolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil..pdf.txtExtracted texttext/plain21834https://www.arca.fiocruz.br/bitstream/icict/35956/3/Evolutionary%20study%20of%20potentially%20zoonotic%20hepatitis%20E%20virus%20genotype%203%20from%20swine%20in%20Northeast%20Brazil..pdf.txta5fd63af1b3241c7e73ca3a5fe5455dcMD53icict/359562019-09-28 23:08:52.644oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-09-29T02:08:52Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil
title Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil
spellingShingle Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil
Oliveira-Filho, Edmilson Ferreira de
Zoonotic hepatitis E virus
Swine
Genotype 3
Animais
Brasil
Capsídeo
Virologia
Fezes
Genótipo
Hepatite E
Vírus da Hepatite E
Genética
Isolamento & purificação
Humanos
Filogenia
RNA Viral
Reação em Cadeia da Polimerase em Tempo Real
Análise de Sequência de DNA
Suínos
Doenças dos Suínos
Transmissão
Zoonoses
title_short Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil
title_full Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil
title_fullStr Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil
title_full_unstemmed Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil
title_sort Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil
author Oliveira-Filho, Edmilson Ferreira de
author_facet Oliveira-Filho, Edmilson Ferreira de
Santos, Debora R. l. dos
Durães-Carvalho, Ricardo
Silva, Adalúcia da
Lima, Gustavo Barbosa de
Batista Filho, Antônio Fernando B.
Pena, Lindomar J.
Gil, Laura H.V. G.
author_role author
author2 Santos, Debora R. l. dos
Durães-Carvalho, Ricardo
Silva, Adalúcia da
Lima, Gustavo Barbosa de
Batista Filho, Antônio Fernando B.
Pena, Lindomar J.
Gil, Laura H.V. G.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira-Filho, Edmilson Ferreira de
Santos, Debora R. l. dos
Durães-Carvalho, Ricardo
Silva, Adalúcia da
Lima, Gustavo Barbosa de
Batista Filho, Antônio Fernando B.
Pena, Lindomar J.
Gil, Laura H.V. G.
dc.subject.en.pt_BR.fl_str_mv Zoonotic hepatitis E virus
Swine
Genotype 3
topic Zoonotic hepatitis E virus
Swine
Genotype 3
Animais
Brasil
Capsídeo
Virologia
Fezes
Genótipo
Hepatite E
Vírus da Hepatite E
Genética
Isolamento & purificação
Humanos
Filogenia
RNA Viral
Reação em Cadeia da Polimerase em Tempo Real
Análise de Sequência de DNA
Suínos
Doenças dos Suínos
Transmissão
Zoonoses
dc.subject.decs.pt_BR.fl_str_mv Animais
Brasil
Capsídeo
Virologia
Fezes
Genótipo
Hepatite E
Vírus da Hepatite E
Genética
Isolamento & purificação
Humanos
Filogenia
RNA Viral
Reação em Cadeia da Polimerase em Tempo Real
Análise de Sequência de DNA
Suínos
Doenças dos Suínos
Transmissão
Zoonoses
description Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil / Charité-Universitätsmedizin Berlin. Berlin Institute of Health. Institute of Virology. Berlin, Germany.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-09-27T13:48:14Z
dc.date.available.fl_str_mv 2019-09-27T13:48:14Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA-FILHO, Edmilson Ferreira de et al. Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-5, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35956
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760180585
identifier_str_mv OLIVEIRA-FILHO, Edmilson Ferreira de et al. Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-5, 2019.
0074-0276
10.1590/0074-02760180585
url https://www.arca.fiocruz.br/handle/icict/35956
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/35956/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/35956/2/Evolutionary%20study%20of%20potentially%20zoonotic%20hepatitis%20E%20virus%20genotype%203%20from%20swine%20in%20Northeast%20Brazil..pdf
https://www.arca.fiocruz.br/bitstream/icict/35956/3/Evolutionary%20study%20of%20potentially%20zoonotic%20hepatitis%20E%20virus%20genotype%203%20from%20swine%20in%20Northeast%20Brazil..pdf.txt
bitstream.checksum.fl_str_mv 4194663c61da82c21746deb8d6361188
2a9dce848f940d9c83c57a7209deddb1
a5fd63af1b3241c7e73ca3a5fe5455dc
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1822792090453540864

Registros relacionados