Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological and Clinical Evaluation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14133 |
Resumo: | Funda ção Oswaldo Cruz. Centro dePesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Cézar, Rodrigo SilvaCerqueira, Bruno Antonio VelosoPaz, Silvana de Souza daBarbosa, Cynara GomesMoura Neto, José PereiaBarreto, José Henrique SilvaGoncalves, Marilda de Souza2016-05-09T17:29:58Z2016-05-09T17:29:58Z2015CEZAR, R. S. et al. Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological and Clinical Evaluation. Journal of Pediatric Hematology/Oncology, v. 37, n. 6, p.423-428, 2015.1077-4114https://www.arca.fiocruz.br/handle/icict/14133engLippincott, Williams & WilkinsOutcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological and Clinical Evaluationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFunda ção Oswaldo Cruz. Centro dePesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade do Estado da Bahia. UNEB. wDepartmento de Ciências da Vida. DCV. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilUniversidade Federal do Amazonas. Faculdade de Farmácia. Amazonas, MA, BrasilInstituto Nacional de Ciência e Tecnologia do Sangue. INCT. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal do Amazonas. Faculdade de Farmácia. Amazonas, MA, BrasilSummary: The aim of this study is to investigate the clinical, hematological, and immunophenotypic characteristics of Brazilian children with B-cell acute lymphoblastic leukemia (B-ALL) to identify prognostic biomarkers of the disease. Thirty-three children newly diagnosed with B-ALL were followed between March 2004 and December 2009. Information about the demographic profile, diagnosis, immunophenotype, clinical manifestations, and disease outcome were gathered from the patients’ medical records. Of the 33 patients with B-ALL, 18 were male and 15 female. Eighteen patients were classified as high risk; 13 as low risk, and 2 as true low risk. The frequencies of cluster of differentiation (CD)10, CD19, and CD20 antigens were 69.7%, 81.8%, and 18.2%, respectively. Six patients (18.2%) had aberrant expression of myeloid antigens. At diagnosis, patients immunopositive for CD20 had elevated white blood cell counts (P=0.018) and lower platelet counts (P=0.017). The 6-year overall survival was 67.5%±3.47%. Our results demonstrate the distinct immunophenotypic and prognostic characteristics of patients with B-ALL, which can be related to the Brazilian racial admixture. Consequently, these results will most likely aid in the selection of additional prognostic markers and their use in monitoring the clinical manifestations and treatment response among B-ALL patients.Acute lymphoblastic leukemiaImmunophenotypeChildhoodinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14133/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCezar RS Outcome of b-cell....pdfCezar RS Outcome of b-cell....pdfapplication/pdf175207https://www.arca.fiocruz.br/bitstream/icict/14133/2/Cezar%20RS%20Outcome%20of%20b-cell....pdf122962f2f844b84a3acc8384268c7001MD52TEXTCezar RS Outcome of b-cell....pdf.txtCezar RS Outcome of b-cell....pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological and Clinical Evaluation |
| title |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological and Clinical Evaluation |
| spellingShingle |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological and Clinical Evaluation Cézar, Rodrigo Silva Acute lymphoblastic leukemia Immunophenotype Childhood |
| title_short |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological and Clinical Evaluation |
| title_full |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological and Clinical Evaluation |
| title_fullStr |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological and Clinical Evaluation |
| title_full_unstemmed |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological and Clinical Evaluation |
| title_sort |
Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological and Clinical Evaluation |
| author |
Cézar, Rodrigo Silva |
| author_facet |
Cézar, Rodrigo Silva Cerqueira, Bruno Antonio Veloso Paz, Silvana de Souza da Barbosa, Cynara Gomes Moura Neto, José Pereia Barreto, José Henrique Silva Goncalves, Marilda de Souza |
| author_role |
author |
| author2 |
Cerqueira, Bruno Antonio Veloso Paz, Silvana de Souza da Barbosa, Cynara Gomes Moura Neto, José Pereia Barreto, José Henrique Silva Goncalves, Marilda de Souza |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Cézar, Rodrigo Silva Cerqueira, Bruno Antonio Veloso Paz, Silvana de Souza da Barbosa, Cynara Gomes Moura Neto, José Pereia Barreto, José Henrique Silva Goncalves, Marilda de Souza |
| dc.subject.en.pt_BR.fl_str_mv |
Acute lymphoblastic leukemia Immunophenotype Childhood |
| topic |
Acute lymphoblastic leukemia Immunophenotype Childhood |
| description |
Funda ção Oswaldo Cruz. Centro dePesquisas Gonçalo Moniz. Salvador, BA, Brasil |
| publishDate |
2015 |
| dc.date.issued.fl_str_mv |
2015 |
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2016-05-09T17:29:58Z |
| dc.date.available.fl_str_mv |
2016-05-09T17:29:58Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
CEZAR, R. S. et al. Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological and Clinical Evaluation. Journal of Pediatric Hematology/Oncology, v. 37, n. 6, p.423-428, 2015. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/14133 |
| dc.identifier.issn.none.fl_str_mv |
1077-4114 |
| identifier_str_mv |
CEZAR, R. S. et al. Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological and Clinical Evaluation. Journal of Pediatric Hematology/Oncology, v. 37, n. 6, p.423-428, 2015. 1077-4114 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Lippincott, Williams & Wilkins |
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Lippincott, Williams & Wilkins |
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