Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31552 |
Resumo: | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Ribeirão Preto, SP, Brasil. |
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Almeida, FernandaSeribelli, Amanda AparecidaMedeiros, Marta Inês CazentiniRodrigues, Dália dos PrazeresVarani, Alessandro de MelloLuo, YanAllard, Marc W.Falcão, Juliana Pfrimer2019-02-12T10:56:00Z2019-02-12T10:56:00Z2018ALMEIDA, Fernanda; et al. Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing. Plos One, v.13, n.8, e0201882, 16p, Aug. 2018.1932-6203https://www.arca.fiocruz.br/handle/icict/3155210.1371/journal.pone.0201882engPublic Library of ScienceSequenciamento Completo do GenomaCepasSalmonella TyphimuriumResistência antimicrobianaFilogenéticaAnálise genéticaBrasilSalmonella TyphimuriumStrainsWhole Genome SequencingAntimicrobial resistancePhylogeneticGene analysisBrazilPhylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencinginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Ribeirão Preto, SP, Brasil.Instituto Adolfo Lutz. Centro de Laboratório Regional de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterobactérias. Rio de Janeiro, RJ. Brasil.Universidade Estadual Paulista. Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal, SP, Brasil..U.S. Food and Drug Administration. Center for Food Safety and Applied Nutrition. Division of Microbiology, Office of Regular Science. College Park, Maryland, USA.U.S. Food and Drug Administration. Center for Food Safety and Applied Nutrition. Division of Microbiology, Office of Regular Science. College Park, Maryland, USA.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Ribeirão Preto, SP, Brasil.Whole genome sequencing (WGS) has been used as a powerful technology for molecular epidemiology, surveillance, identification of species and serotype, identification of the sources of outbreaks, among other purposes. In Brazil, there is relatively few epidemiological data on Salmonella. In this study, 90 Salmonella Typhimurium strains had their genome sequenced to uncover the diversity of Salmonella Typhimurium isolated from humans and food, between 1983 and 2013, from different geographic regions in Brazil based on single nucleotide polymorphism (SNP) analysis. A total of 39 resistance genes were identified, such as aminoglycoside, tetracycline, sulfonamide, trimethoprim, beta-lactam, fluoroquinolone, phenicol and macrolide, as well as the occurrence of point mutations in some of the genes such as gyrA, gyrB, parC and parE. A total of 65 (72.2%) out of 90 S. Typhimurium strains studied were phenotypically resistant to sulfonamides, 44 (48.9%) strains were streptomycin resistant, 27 (30%) strains were resistant to tetracycline, 21 (23.3%) strains were gentamicin resistant, and seven (7.8%) strains were resistant to ceftriaxone. In the gyrA gene, it was observed the following amino acid substitutions: Asp(87)→Gly, Asp(87)→Asn, Ser(83)→Phe, Ser(83)→Tyr. Phylogenetic results placed the 90 S. Typhimurium strains into two major clades suggesting the existence of a prevalent subtype, likely more adapted, among strains isolated from humans, with some diversity in subtypes in foods. The variety and prevalence of resistant genes found in these Salmonella Typhimurium strains reinforces their potential hazard for humans and the risk in foods in Brazil.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31552/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALdaliaprazeres_rodrigues_etal_IOC_2018.pdfdaliaprazeres_rodrigues_etal_IOC_2018.pdfapplication/pdf2669595https://www.arca.fiocruz.br/bitstream/icict/31552/2/daliaprazeres_rodrigues_etal_IOC_2018.pdf16bd34017bb4d9764d10864f5600f6f1MD52TEXTdaliaprazeres_rodrigues_etal_IOC_2018.pdf.txtdaliaprazeres_rodrigues_etal_IOC_2018.pdf.txtExtracted texttext/plain61033https://www.arca.fiocruz.br/bitstream/icict/31552/3/daliaprazeres_rodrigues_etal_IOC_2018.pdf.txtd58ea4f553d5b2e5fa3e59a96060502dMD53icict/315522019-02-13 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dc.title.pt_BR.fl_str_mv |
Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing |
title |
Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing |
spellingShingle |
Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing Almeida, Fernanda Sequenciamento Completo do Genoma Cepas Salmonella Typhimurium Resistência antimicrobiana Filogenética Análise genética Brasil Salmonella Typhimurium Strains Whole Genome Sequencing Antimicrobial resistance Phylogenetic Gene analysis Brazil |
title_short |
Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing |
title_full |
Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing |
title_fullStr |
Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing |
title_full_unstemmed |
Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing |
title_sort |
Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing |
author |
Almeida, Fernanda |
author_facet |
Almeida, Fernanda Seribelli, Amanda Aparecida Medeiros, Marta Inês Cazentini Rodrigues, Dália dos Prazeres Varani, Alessandro de Mello Luo, Yan Allard, Marc W. Falcão, Juliana Pfrimer |
author_role |
author |
author2 |
Seribelli, Amanda Aparecida Medeiros, Marta Inês Cazentini Rodrigues, Dália dos Prazeres Varani, Alessandro de Mello Luo, Yan Allard, Marc W. Falcão, Juliana Pfrimer |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Almeida, Fernanda Seribelli, Amanda Aparecida Medeiros, Marta Inês Cazentini Rodrigues, Dália dos Prazeres Varani, Alessandro de Mello Luo, Yan Allard, Marc W. Falcão, Juliana Pfrimer |
dc.subject.other.pt_BR.fl_str_mv |
Sequenciamento Completo do Genoma Cepas Salmonella Typhimurium Resistência antimicrobiana Filogenética Análise genética Brasil |
topic |
Sequenciamento Completo do Genoma Cepas Salmonella Typhimurium Resistência antimicrobiana Filogenética Análise genética Brasil Salmonella Typhimurium Strains Whole Genome Sequencing Antimicrobial resistance Phylogenetic Gene analysis Brazil |
dc.subject.en.pt_BR.fl_str_mv |
Salmonella Typhimurium Strains Whole Genome Sequencing Antimicrobial resistance Phylogenetic Gene analysis Brazil |
description |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Ribeirão Preto, SP, Brasil. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-02-12T10:56:00Z |
dc.date.available.fl_str_mv |
2019-02-12T10:56:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ALMEIDA, Fernanda; et al. Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing. Plos One, v.13, n.8, e0201882, 16p, Aug. 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/31552 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0201882 |
identifier_str_mv |
ALMEIDA, Fernanda; et al. Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing. Plos One, v.13, n.8, e0201882, 16p, Aug. 2018. 1932-6203 10.1371/journal.pone.0201882 |
url |
https://www.arca.fiocruz.br/handle/icict/31552 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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Public Library of Science |
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Public Library of Science |
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