Potent activity of a high concentration of chemical ozone against antibiotic-resistant bacteria

Detalhes bibliográficos
Autor(a) principal: Rangel, Karyne
Data de Publicação: 2022
Outros Autores: Cabral, Fellipe O., Lechuga, Guilherme C., Carvalho, João P. R. S., Villas-Bôas, Maria H. S., Midlej, Victor, De-Simone, Salvatore G.
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/60983
Resumo: Oswaldo Cruz Foundation. Center for Technological Development in Health. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Oswaldo Cruz Institute. National Institute of Science and Technology for Innovation in Neglected Population Diseases. Rio de Janeiro, RJ, Brasil.
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spelling Rangel, KaryneCabral, Fellipe O.Lechuga, Guilherme C.Carvalho, João P. R. S.Villas-Bôas, Maria H. S.Midlej, VictorDe-Simone, Salvatore G.2023-10-30T14:05:35Z2023-10-30T14:05:35Z2022RANGEL, Karine et al. Potent Activity of a High Concentration of Chemical Ozone against Antibiotic-Resistant Bacteria. In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 32., 2023, Foz do Iguaçu: SBM, 2023. 1 p.https://www.arca.fiocruz.br/handle/icict/60983engFiocruz/INCQSOzônioBactéria patogênicaResistência antimicrobianaSEMPatógenos ESKAPEActividade antimicrobianaOzonePathogenic bacteriaAntimicrobial resistanceSEMESKAPE pathogensAntimicrobial activityPotent activity of a high concentration of chemical ozone against antibiotic-resistant bacteriainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectOswaldo Cruz Foundation. Center for Technological Development in Health. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Oswaldo Cruz Institute. National Institute of Science and Technology for Innovation in Neglected Population Diseases. Rio de Janeiro, RJ, Brasil.Federal Fluminense University. Biology Institute. Department of Molecular and Cellular Biology. Post-Graduation Program in Science and Biotechnology. Niterói, RJ, Brazil.Oswaldo Cruz Foundation. Center for Technological Development in Health. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Oswaldo Cruz Institute. National Institute of Science and Technology for Innovation in Neglected Population Diseases. Rio de Janeiro, RJ, Brasil.Oswaldo Cruz Foundation. Center for Technological Development in Health. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Oswaldo Cruz Institute. National Institute of Science and Technology for Innovation in Neglected Population Diseases. Rio de Janeiro, RJ, Brasil.Oswaldo Cruz Foundation. National Institute for Quality Control in Health. Microbiology Department. Rio de Janeiro, RJ, Brasil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Cellular and Ultrastructure. Rio de Janeiro, RJ, Brasil.Oswaldo Cruz Foundation. Center for Technological Development in Health. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Oswaldo Cruz Institute. National Institute of Science and Technology for Innovation in Neglected Population Diseases. Rio de Janeiro, RJ, Brasil.Background: Health care-associated infections (HAIs) are a significant public health problem worldwide, favoring multidrug-resistant (MDR) microorganisms. The SARS-CoV-2 infection was negatively associated with the increase in antimicrobial resistance, and the ESKAPE group had the most significant impact on HAIs. The study evaluated the bactericidal effect of a high concentration of O3 gas on some reference and ESKAPE bacteria. Material and Methods: Four standard strains and four clinical or environmental MDR strains were exposed to elevated ozone doses at different concentrations and times. Bacterial inactivation (growth and cultivability) was investigated using colony counts and resazurin as metabolic indicators. Scanning electron microscopy (SEM) was performed. Results: The culture exposure to a high level of O3 inhibited the growth of all bacterial strains tested with a statistically significant reduction in colony count compared to the control group. The cell viability of S. aureus (MRSA) (99.6%) and P. aeruginosa (XDR) (29.2%) was reduced considerably, and SEM showed damage to bacteria after O3 treatment Conclusion: The impact of HAIs can be easily dampened by the widespread use of ozone in ICUs. This product usually degrades into molecular oxygen and has a low toxicity compared to other sanitization products. However, high doses of ozone were able to interfere with the growth of all strains studied, evidencing that ozone-based decontamination approaches may represent the future of hospital cleaning methods.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60983/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL2023_poster_32cbm_karine-rangel.pdf2023_poster_32cbm_karine-rangel.pdfArtigo principalapplication/pdf656472https://www.arca.fiocruz.br/bitstream/icict/60983/2/2023_poster_32cbm_karine-rangel.pdf7234b68e310579b6681f0c3d6e686cb0MD52icict/609832023-10-30 12:22:39.937oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-10-30T15:22:39Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.en_US.fl_str_mv Potent activity of a high concentration of chemical ozone against antibiotic-resistant bacteria
title Potent activity of a high concentration of chemical ozone against antibiotic-resistant bacteria
spellingShingle Potent activity of a high concentration of chemical ozone against antibiotic-resistant bacteria
Rangel, Karyne
Ozônio
Bactéria patogênica
Resistência antimicrobiana
SEM
Patógenos ESKAPE
Actividade antimicrobiana
Ozone
Pathogenic bacteria
Antimicrobial resistance
SEM
ESKAPE pathogens
Antimicrobial activity
title_short Potent activity of a high concentration of chemical ozone against antibiotic-resistant bacteria
title_full Potent activity of a high concentration of chemical ozone against antibiotic-resistant bacteria
title_fullStr Potent activity of a high concentration of chemical ozone against antibiotic-resistant bacteria
title_full_unstemmed Potent activity of a high concentration of chemical ozone against antibiotic-resistant bacteria
title_sort Potent activity of a high concentration of chemical ozone against antibiotic-resistant bacteria
author Rangel, Karyne
author_facet Rangel, Karyne
Cabral, Fellipe O.
Lechuga, Guilherme C.
Carvalho, João P. R. S.
Villas-Bôas, Maria H. S.
Midlej, Victor
De-Simone, Salvatore G.
author_role author
author2 Cabral, Fellipe O.
Lechuga, Guilherme C.
Carvalho, João P. R. S.
Villas-Bôas, Maria H. S.
Midlej, Victor
De-Simone, Salvatore G.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rangel, Karyne
Cabral, Fellipe O.
Lechuga, Guilherme C.
Carvalho, João P. R. S.
Villas-Bôas, Maria H. S.
Midlej, Victor
De-Simone, Salvatore G.
dc.subject.other.en_US.fl_str_mv Ozônio
Bactéria patogênica
Resistência antimicrobiana
SEM
Patógenos ESKAPE
Actividade antimicrobiana
topic Ozônio
Bactéria patogênica
Resistência antimicrobiana
SEM
Patógenos ESKAPE
Actividade antimicrobiana
Ozone
Pathogenic bacteria
Antimicrobial resistance
SEM
ESKAPE pathogens
Antimicrobial activity
dc.subject.en.en_US.fl_str_mv Ozone
Pathogenic bacteria
Antimicrobial resistance
SEM
ESKAPE pathogens
Antimicrobial activity
description Oswaldo Cruz Foundation. Center for Technological Development in Health. Rio de Janeiro, RJ, Brasil / Oswaldo Cruz Foundation. Oswaldo Cruz Institute. National Institute of Science and Technology for Innovation in Neglected Population Diseases. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-10-30T14:05:35Z
dc.date.available.fl_str_mv 2023-10-30T14:05:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
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status_str publishedVersion
dc.identifier.citation.fl_str_mv RANGEL, Karine et al. Potent Activity of a High Concentration of Chemical Ozone against Antibiotic-Resistant Bacteria. In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 32., 2023, Foz do Iguaçu: SBM, 2023. 1 p.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/60983
identifier_str_mv RANGEL, Karine et al. Potent Activity of a High Concentration of Chemical Ozone against Antibiotic-Resistant Bacteria. In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 32., 2023, Foz do Iguaçu: SBM, 2023. 1 p.
url https://www.arca.fiocruz.br/handle/icict/60983
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/INCQS
publisher.none.fl_str_mv Fiocruz/INCQS
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/60983/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/60983/2/2023_poster_32cbm_karine-rangel.pdf
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