Inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs Trypanosoma cruzi Entry into Cardiac Cells and Promotes Differential Modulation of the Inflammatory Response

Detalhes bibliográficos
Autor(a) principal: Malvezi, Aparecida Donizette
Data de Publicação: 2014
Outros Autores: Panis, Carolina, Silva, Rosiane Valeriano da, Freitas, Rafael Carvalho, Lovo-Martins, Maria Isabel, Tatakihara, Vera Lúcia Hideko, Zanluqui, Nágela Ghabdan, Goldenberg, Samuel, Bordignon, Juliano, Yamada-Ogatta, Sueli Fumie, Martins-Pinge, Marli Cardoso, Cecchini, Rubens, Pinge-Filho, Phileno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8946
Resumo: This work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil (CNPq; 302097/2010-474792/2011-0), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and by the Fundação Araucaria (Convênio 419/2009).
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spelling Malvezi, Aparecida DonizettePanis, CarolinaSilva, Rosiane Valeriano daFreitas, Rafael CarvalhoLovo-Martins, Maria IsabelTatakihara, Vera Lúcia HidekoZanluqui, Nágela GhabdanGoldenberg, SamuelBordignon, JulianoYamada-Ogatta, Sueli FumieMartins-Pinge, Marli CardosoCecchini, RubensPinge-Filho, Phileno2014-11-24T17:06:59Z2014-11-24T17:06:59Z2014MALVEZI, A. et al. Inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs Trypanosoma cruzi Entry into Cardiac Cells and Promotes Differential Modulation of the Inflammatory Response. Antimicrobial Agents and Chemotherapy, v. 58, p. 6157-6164, 2014. 0066-4804https://www.arca.fiocruz.br/handle/icict/894610.1128/AAC.02752-14This work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil (CNPq; 302097/2010-474792/2011-0), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and by the Fundação Araucaria (Convênio 419/2009).Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brazil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Centro de Ciências Biológicas. Laboratório de Patofisiologia e Radicais Livres. Londrina, PR, Brazil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brazil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brazil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brazil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brazil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brazil.Universidade de São Paulo. Faculdade de Medicina. Instituto do Coração. Laboratório de Immunologia. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil.Universidade Estadual de Londrina. Departamento de Microbiologia. Centro de Ciências Biológicas. Laboratório de Biologia Molecular de Microrganismos. Londrina, PR, Brazil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Fisiológicas. Londrina, PR, Brazil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Centro de Ciências Biológicas. Laboratório de Patofisiologia e Radicais Livres. Londrina, PR, Brazil.The intracellular protozoan parasite Trypanosoma cruzi is the etiologic agent of Chagas disease, a serious disorder that affects millions of people in Latin America. Cell invasion by T. cruzi and its intracellular replication are essential to the parasite’s life cycle and for the development of Chagas disease. Here, we present evidence suggesting the involvement of the host’s cyclooxygenase (COX) enzymes during T. cruzi invasion. Pharmacological antagonists for COX-1 (aspirin) and COX-2 (celecoxib) caused marked inhibition of T. cruzi infection when rat cardiac cells were pretreated with these nonsteroidal anti-inflammatory drugs (NSAIDs) for 60 min at 37°C before inoculation. This inhibition was associated with an increase in the production of NO and interleukin-1 and decreased production of transforming growth factor (TGF- ) by cells. Taken together, these results indicate that COX-1 more than COX-2 is involved in the regulation of anti-T. cruzi activity in cardiac cells, and they provide a better understanding of the influence of TGF- -interfering therapies on the innate inflammatory response to T. cruzi infection and may represent a very pertinent target for new therapeutic treatments of Chagas disease.engJournal.ASM.orgInhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs Trypanosoma cruzi Entry into Cardiac Cells and Promotes Differential Modulation of the Inflammatory Responseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCyclooxygenase 1Cyclooxygenase 2MyocytesInflammationCiclooxigenasa 1Ciclooxigenasa 2Miocitos CardíacosInflamaciónCiclo-Oxigenase 1Ciclo-Oxigenase 2Miócitos CardíacosInflamaçãoTrypanosoma Cruziinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8946/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALInhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs T cruzi entry into cardiac cells and promotes differential modulation of the inflammatory response.pdfInhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs T cruzi entry into cardiac cells and promotes differential modulation of the inflammatory response.pdfapplication/pdf1172008https://www.arca.fiocruz.br/bitstream/icict/8946/2/Inhibition%20of%20Cyclooxygenase-1%20and%20Cyclooxygenase-2%20Impairs%20T%20cruzi%20entry%20into%20cardiac%20cells%20and%20promotes%20differential%20modulation%20of%20the%20inflammatory%20response.pdf786e51ba3aeb32d5ec8379350fef5f56MD52TEXTInhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs T cruzi entry into cardiac cells and promotes differential modulation of the inflammatory response.pdf.txtInhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs T cruzi entry into cardiac cells and promotes differential modulation of the inflammatory response.pdf.txtExtracted texttext/plain48501https://www.arca.fiocruz.br/bitstream/icict/8946/3/Inhibition%20of%20Cyclooxygenase-1%20and%20Cyclooxygenase-2%20Impairs%20T%20cruzi%20entry%20into%20cardiac%20cells%20and%20promotes%20differential%20modulation%20of%20the%20inflammatory%20response.pdf.txt4ed1c136ab5fb1e7ff551604625452f6MD53icict/89462019-11-04 14:23:22.344oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-11-04T17:23:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs Trypanosoma cruzi Entry into Cardiac Cells and Promotes Differential Modulation of the Inflammatory Response
title Inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs Trypanosoma cruzi Entry into Cardiac Cells and Promotes Differential Modulation of the Inflammatory Response
spellingShingle Inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs Trypanosoma cruzi Entry into Cardiac Cells and Promotes Differential Modulation of the Inflammatory Response
Malvezi, Aparecida Donizette
Cyclooxygenase 1
Cyclooxygenase 2
Myocytes
Inflammation
Ciclooxigenasa 1
Ciclooxigenasa 2
Miocitos Cardíacos
Inflamación
Ciclo-Oxigenase 1
Ciclo-Oxigenase 2
Miócitos Cardíacos
Inflamação
Trypanosoma Cruzi
title_short Inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs Trypanosoma cruzi Entry into Cardiac Cells and Promotes Differential Modulation of the Inflammatory Response
title_full Inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs Trypanosoma cruzi Entry into Cardiac Cells and Promotes Differential Modulation of the Inflammatory Response
title_fullStr Inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs Trypanosoma cruzi Entry into Cardiac Cells and Promotes Differential Modulation of the Inflammatory Response
title_full_unstemmed Inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs Trypanosoma cruzi Entry into Cardiac Cells and Promotes Differential Modulation of the Inflammatory Response
title_sort Inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs Trypanosoma cruzi Entry into Cardiac Cells and Promotes Differential Modulation of the Inflammatory Response
author Malvezi, Aparecida Donizette
author_facet Malvezi, Aparecida Donizette
Panis, Carolina
Silva, Rosiane Valeriano da
Freitas, Rafael Carvalho
Lovo-Martins, Maria Isabel
Tatakihara, Vera Lúcia Hideko
Zanluqui, Nágela Ghabdan
Goldenberg, Samuel
Bordignon, Juliano
Yamada-Ogatta, Sueli Fumie
Martins-Pinge, Marli Cardoso
Cecchini, Rubens
Pinge-Filho, Phileno
author_role author
author2 Panis, Carolina
Silva, Rosiane Valeriano da
Freitas, Rafael Carvalho
Lovo-Martins, Maria Isabel
Tatakihara, Vera Lúcia Hideko
Zanluqui, Nágela Ghabdan
Goldenberg, Samuel
Bordignon, Juliano
Yamada-Ogatta, Sueli Fumie
Martins-Pinge, Marli Cardoso
Cecchini, Rubens
Pinge-Filho, Phileno
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Malvezi, Aparecida Donizette
Panis, Carolina
Silva, Rosiane Valeriano da
Freitas, Rafael Carvalho
Lovo-Martins, Maria Isabel
Tatakihara, Vera Lúcia Hideko
Zanluqui, Nágela Ghabdan
Goldenberg, Samuel
Bordignon, Juliano
Yamada-Ogatta, Sueli Fumie
Martins-Pinge, Marli Cardoso
Cecchini, Rubens
Pinge-Filho, Phileno
dc.subject.en.En.fl_str_mv Cyclooxygenase 1
Cyclooxygenase 2
Myocytes
Inflammation
topic Cyclooxygenase 1
Cyclooxygenase 2
Myocytes
Inflammation
Ciclooxigenasa 1
Ciclooxigenasa 2
Miocitos Cardíacos
Inflamación
Ciclo-Oxigenase 1
Ciclo-Oxigenase 2
Miócitos Cardíacos
Inflamação
Trypanosoma Cruzi
dc.subject.es.Es.fl_str_mv Ciclooxigenasa 1
Ciclooxigenasa 2
Miocitos Cardíacos
Inflamación
dc.subject.decs.pt_BR.fl_str_mv Ciclo-Oxigenase 1
Ciclo-Oxigenase 2
Miócitos Cardíacos
Inflamação
Trypanosoma Cruzi
description This work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil (CNPq; 302097/2010-474792/2011-0), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and by the Fundação Araucaria (Convênio 419/2009).
publishDate 2014
dc.date.accessioned.fl_str_mv 2014-11-24T17:06:59Z
dc.date.available.fl_str_mv 2014-11-24T17:06:59Z
dc.date.issued.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MALVEZI, A. et al. Inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs Trypanosoma cruzi Entry into Cardiac Cells and Promotes Differential Modulation of the Inflammatory Response. Antimicrobial Agents and Chemotherapy, v. 58, p. 6157-6164, 2014. 
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8946
dc.identifier.issn.none.fl_str_mv 0066-4804
dc.identifier.doi.none.fl_str_mv 10.1128/AAC.02752-14
identifier_str_mv MALVEZI, A. et al. Inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs Trypanosoma cruzi Entry into Cardiac Cells and Promotes Differential Modulation of the Inflammatory Response. Antimicrobial Agents and Chemotherapy, v. 58, p. 6157-6164, 2014. 
0066-4804
10.1128/AAC.02752-14
url https://www.arca.fiocruz.br/handle/icict/8946
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Journal.ASM.org
publisher.none.fl_str_mv Journal.ASM.org
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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