Meningeal sporotrichosis due to Sporothrix brasiliensis: a 21-year cohort study from a Brazilian reference center
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57358 |
Resumo: | 2023 |
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Lima, Marco A.Freitas, Dayvison F. S.Oliveira, Raquel V. C.Fichman, VivianVaron, Andréa G.Freitas, Andréa D.Lamas, Cristiane C.Andrade, Hugo B.Veloso, Valdiléa G.Almeida-Paes, RodrigoAlmeida-Silva, FernandoZancopé-Oliveira, Rosely MariaMacedo, Priscila M. deValle, Antonio C. F.Silva, Marcus T. T.Araújo, Abelardo Q. C.Gutierrez-Galhardo, Maria2023-03-14T13:59:36Z2023-03-14T13:59:36Z2023LIMA, Marco A. et al. Meningeal sporotrichosis due to Sporothrix brasiliensis: a 21-year cohort study from a Brazilian reference center. Journal of Fungi, v. 9, n. 1, p. 1-12, 2023.2309-608Xhttps://www.arca.fiocruz.br/handle/icict/5735810.3390/jof90100172309-608XengMDPISporothrix brasiliensisEsporotricoseMeningiteHIVSíndrome inflamatória da reconstituição imunológicaSporothrix brasiliensisSporotrichosisMeningitisHIVImmune reconstitution inflammatory syndromeMeningeal sporotrichosis due to Sporothrix brasiliensis: a 21-year cohort study from a Brazilian reference centerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2023Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil / Federal University of Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Neurology Section. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil / Federal University of Rio de Janeiro. Deolindo Couto Institute of Neurology. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.Meningeal sporotrichosis is rare and occurs predominantly in immunosuppressed indi viduals. This retrospective study explored clinical and laboratory characteristics, treatment, and prognosis of patients with disseminated sporotrichosis who underwent lumbar puncture (LP) at a Brazilian reference center from 1999 to 2020. Kaplan–Meier and Cox regression models were used to estimate overall survival and hazard ratios. Among 57 enrolled patients, 17 had meningitis. Fifteen (88.2%) had HIV infection, and in 6 of them, neurological manifestations occurred because of the immune reconstitution inflammatory syndrome (IRIS). The most frequent symptom was headache (88.2%). Meningeal symptoms at first LP were absent in 7/17 (41.2%) patients. Sporothrix was diagnosed in cerebrospinal fluid either by culture or by polymerase chain reaction in seven and four patients, respectively. All but one patient received prolonged courses of amphotericin B formulations, and seven received posaconazole, but relapses were frequent. Lethality among patients with meningitis was 64.7%, with a higher chance of death compared to those without meningitis (HR = 3.87; IC95% = 1.23;12.17). Meningeal sporotrichosis occurs mostly in people with HIV and can be associated with IRIS. Screening LP is indicated in patients with disseminated disease despite the absence of neurological complaints. Meningitis is associated with poor prognosis, and better treatment strategies are needed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57358/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Lima_Marco_etal_INI_2023.pdfve_Lima_Marco_etal_INI_2023.pdfapplication/pdf1717365https://www.arca.fiocruz.br/bitstream/icict/57358/2/ve_Lima_Marco_etal_INI_2023.pdf02a9418cad63588d1f39c69ef3e5c2f1MD52icict/573582023-04-04 12:55:57.442oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-04-04T15:55:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.en_US.fl_str_mv |
Meningeal sporotrichosis due to Sporothrix brasiliensis: a 21-year cohort study from a Brazilian reference center |
title |
Meningeal sporotrichosis due to Sporothrix brasiliensis: a 21-year cohort study from a Brazilian reference center |
spellingShingle |
Meningeal sporotrichosis due to Sporothrix brasiliensis: a 21-year cohort study from a Brazilian reference center Lima, Marco A. Sporothrix brasiliensis Esporotricose Meningite HIV Síndrome inflamatória da reconstituição imunológica Sporothrix brasiliensis Sporotrichosis Meningitis HIV Immune reconstitution inflammatory syndrome |
title_short |
Meningeal sporotrichosis due to Sporothrix brasiliensis: a 21-year cohort study from a Brazilian reference center |
title_full |
Meningeal sporotrichosis due to Sporothrix brasiliensis: a 21-year cohort study from a Brazilian reference center |
title_fullStr |
Meningeal sporotrichosis due to Sporothrix brasiliensis: a 21-year cohort study from a Brazilian reference center |
title_full_unstemmed |
Meningeal sporotrichosis due to Sporothrix brasiliensis: a 21-year cohort study from a Brazilian reference center |
title_sort |
Meningeal sporotrichosis due to Sporothrix brasiliensis: a 21-year cohort study from a Brazilian reference center |
author |
Lima, Marco A. |
author_facet |
Lima, Marco A. Freitas, Dayvison F. S. Oliveira, Raquel V. C. Fichman, Vivian Varon, Andréa G. Freitas, Andréa D. Lamas, Cristiane C. Andrade, Hugo B. Veloso, Valdiléa G. Almeida-Paes, Rodrigo Almeida-Silva, Fernando Zancopé-Oliveira, Rosely Maria Macedo, Priscila M. de Valle, Antonio C. F. Silva, Marcus T. T. Araújo, Abelardo Q. C. Gutierrez-Galhardo, Maria |
author_role |
author |
author2 |
Freitas, Dayvison F. S. Oliveira, Raquel V. C. Fichman, Vivian Varon, Andréa G. Freitas, Andréa D. Lamas, Cristiane C. Andrade, Hugo B. Veloso, Valdiléa G. Almeida-Paes, Rodrigo Almeida-Silva, Fernando Zancopé-Oliveira, Rosely Maria Macedo, Priscila M. de Valle, Antonio C. F. Silva, Marcus T. T. Araújo, Abelardo Q. C. Gutierrez-Galhardo, Maria |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lima, Marco A. Freitas, Dayvison F. S. Oliveira, Raquel V. C. Fichman, Vivian Varon, Andréa G. Freitas, Andréa D. Lamas, Cristiane C. Andrade, Hugo B. Veloso, Valdiléa G. Almeida-Paes, Rodrigo Almeida-Silva, Fernando Zancopé-Oliveira, Rosely Maria Macedo, Priscila M. de Valle, Antonio C. F. Silva, Marcus T. T. Araújo, Abelardo Q. C. Gutierrez-Galhardo, Maria |
dc.subject.other.en_US.fl_str_mv |
Sporothrix brasiliensis Esporotricose Meningite HIV Síndrome inflamatória da reconstituição imunológica |
topic |
Sporothrix brasiliensis Esporotricose Meningite HIV Síndrome inflamatória da reconstituição imunológica Sporothrix brasiliensis Sporotrichosis Meningitis HIV Immune reconstitution inflammatory syndrome |
dc.subject.en.en_US.fl_str_mv |
Sporothrix brasiliensis Sporotrichosis Meningitis HIV Immune reconstitution inflammatory syndrome |
description |
2023 |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-03-14T13:59:36Z |
dc.date.available.fl_str_mv |
2023-03-14T13:59:36Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LIMA, Marco A. et al. Meningeal sporotrichosis due to Sporothrix brasiliensis: a 21-year cohort study from a Brazilian reference center. Journal of Fungi, v. 9, n. 1, p. 1-12, 2023. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/57358 |
dc.identifier.issn.none.fl_str_mv |
2309-608X |
dc.identifier.doi.none.fl_str_mv |
10.3390/jof9010017 |
dc.identifier.eissn.none.fl_str_mv |
2309-608X |
identifier_str_mv |
LIMA, Marco A. et al. Meningeal sporotrichosis due to Sporothrix brasiliensis: a 21-year cohort study from a Brazilian reference center. Journal of Fungi, v. 9, n. 1, p. 1-12, 2023. 2309-608X 10.3390/jof9010017 |
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https://www.arca.fiocruz.br/handle/icict/57358 |
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eng |
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eng |
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MDPI |
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MDPI |
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