The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation

Detalhes bibliográficos
Autor(a) principal: Pérez, Ana Rosa
Data de Publicação: 2020
Outros Autores: Meis, Juliana de, Rodriguez-Galan, Maria Cecilia, Savino, Wilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/45552
Resumo: Universidad Nacional de Rosario. Instituto de Inmunología Clínica y Experimental de Rosario, CONICET. Rosario, Argentina / Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Investigación y Producción de Reactivos Biológicos. Rosario, Argentina.
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spelling Pérez, Ana RosaMeis, Juliana deRodriguez-Galan, Maria CeciliaSavino, Wilson2021-01-10T18:40:38Z2021-01-10T18:40:38Z2020PÉREZ, Ana Rosa et al. The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation. Frontiers in Immunology, v. 11, Article 1838, p. 1-20, Sept. 2020.1664-3224https://www.arca.fiocruz.br/handle/icict/4555210.3389/fimmu.2020.01838engFrontiers MediaDoença de ChagasDepleção de timócitosCélulas epiteliais tímicasExpressão geneticaAdesão e migração celularChagas DiseaseThymocyte depletionThymic epithelial cellsGene expressionCell adhesion and migrationThe Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidad Nacional de Rosario. Instituto de Inmunología Clínica y Experimental de Rosario, CONICET. Rosario, Argentina / Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Investigación y Producción de Reactivos Biológicos. Rosario, Argentina.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rede Rio de Janeiro de Pesquisa em Neuroinflamação. Rio de Janeiro, RJ, Brasil.Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Inmunología, CIBICI CONICET. Rosario, Argentina.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rede Rio de Janeiro de Pesquisa em Neuroinflamação. Rio de Janeiro, RJ, Brasil.Chagas disease, caused by the protozoan parasite T. cruzi, is a prevalent parasitic disease in Latin America. Presently, it is spreading around the world by human migration, thus representing a new global health issue. Chronically infected individuals reveal a dissimilar disease progression: while nearly 60% remain without apparent disease for life, 30% develop life-threatening pathologies, such as chronic chagasic cardiomyopathy (CCC) or megaviscerae. Inflammation driven by parasite persistence seems to be involved in the pathophysiology of the disease. However, there is also evidence of the occurrence of autoimmune events, mainly caused by molecular mimicry and bystander activation. In experimental models of disease, is well-established that T. cruzi infects the thymus and causes locally profound structural and functional alterations. The hallmark is a massive loss of CD4+CD8+ double positive (DP) thymocytes, mainly triggered by increased levels of glucocorticoids, although other mechanisms seem to act simultaneously. Thymic epithelial cells (TEC) exhibited an increase in extracellular matrix deposition, which are related to thymocyte migratory alterations. Moreover, medullary TEC showed a decreased expression of AIRE and altered expression of microRNAs, which might be linked to a disrupted negative selection of the T-cell repertoire. Also, almost all stages of thymocyte development are altered, including an abnormal output of CD4−CD8− double negative (DN) and DP immature and mature cells, many of them carrying prohibited TCR-Vb segments. Evidence has shown that DN and DP cells with an activated phenotype can be tracked in the blood of humans with chronic Chagas disease and also in the secondary lymphoid organs and heart of infected mice, raising new questions about the relevance of these populations in the pathogenesis of Chagas disease and their possible link with thymic alterations and an immunoendocrine imbalance. Here, we discuss diverse molecular mechanisms underlying thymic abnormalities occurring during T. cruzi infection and their link with CCC, which may contribute to the design of innovative strategies to control Chagas disease pathology.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45552/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJulianademeis_WilsonSavino_etal_IOC_2020.pdfJulianademeis_WilsonSavino_etal_IOC_2020.pdfapplication/pdf2205093https://www.arca.fiocruz.br/bitstream/icict/45552/2/Julianademeis_WilsonSavino_etal_IOC_2020.pdfbf12fa3072dcfe43f186f1282fd6a879MD52TEXTJulianademeis_WilsonSavino_etal_IOC_2020.pdf.txtJulianademeis_WilsonSavino_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation
title The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation
spellingShingle The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation
Pérez, Ana Rosa
Doença de Chagas
Depleção de timócitos
Células epiteliais tímicas
Expressão genetica
Adesão e migração celular
Chagas Disease
Thymocyte depletion
Thymic epithelial cells
Gene expression
Cell adhesion and migration
title_short The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation
title_full The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation
title_fullStr The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation
title_full_unstemmed The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation
title_sort The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation
author Pérez, Ana Rosa
author_facet Pérez, Ana Rosa
Meis, Juliana de
Rodriguez-Galan, Maria Cecilia
Savino, Wilson
author_role author
author2 Meis, Juliana de
Rodriguez-Galan, Maria Cecilia
Savino, Wilson
author2_role author
author
author
dc.contributor.author.fl_str_mv Pérez, Ana Rosa
Meis, Juliana de
Rodriguez-Galan, Maria Cecilia
Savino, Wilson
dc.subject.other.pt_BR.fl_str_mv Doença de Chagas
Depleção de timócitos
Células epiteliais tímicas
Expressão genetica
Adesão e migração celular
topic Doença de Chagas
Depleção de timócitos
Células epiteliais tímicas
Expressão genetica
Adesão e migração celular
Chagas Disease
Thymocyte depletion
Thymic epithelial cells
Gene expression
Cell adhesion and migration
dc.subject.en.pt_BR.fl_str_mv Chagas Disease
Thymocyte depletion
Thymic epithelial cells
Gene expression
Cell adhesion and migration
description Universidad Nacional de Rosario. Instituto de Inmunología Clínica y Experimental de Rosario, CONICET. Rosario, Argentina / Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Centro de Investigación y Producción de Reactivos Biológicos. Rosario, Argentina.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-01-10T18:40:38Z
dc.date.available.fl_str_mv 2021-01-10T18:40:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PÉREZ, Ana Rosa et al. The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation. Frontiers in Immunology, v. 11, Article 1838, p. 1-20, Sept. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45552
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2020.01838
identifier_str_mv PÉREZ, Ana Rosa et al. The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation. Frontiers in Immunology, v. 11, Article 1838, p. 1-20, Sept. 2020.
1664-3224
10.3389/fimmu.2020.01838
url https://www.arca.fiocruz.br/handle/icict/45552
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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