Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo: An intravital microscopic study.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8771 |
Resumo: | Universidade Federal de Minas Gerais Departamento de Parasitologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Fisiologia e Biofísica. Núcleo de Neurociências. Belo Horizonte, MG, Brazil |
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Queiroz, Norinne LacerdaLima, Onésia Cristina OliveiraCarneiro, Cláudia MartinsVilela, Márcia CarvalhoTeixeira, Antônio LúcioCarvalho, Andrea TeixeiraAraújo, Márcio Sobreira SilvaMartins Filho, Olindo AssisBraga, Érika MartinsTavares, Juliana Carvalho2014-11-10T13:15:46Z2014-11-10T13:15:46Z2011QUEIROZ, Norinne Lacerda et al. Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo: An intravital microscopic study. Acta Tropica, volume 120, fascisculo 1–2, p.31–39, out-nov. 2011.0001-706X10.1016/j.actatropica.2011.04.020https://www.arca.fiocruz.br/handle/icict/8771engElsevier LtdaPlasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo: An intravital microscopic study.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais Departamento de Parasitologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Fisiologia e Biofísica. Núcleo de Neurociências. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Fisiologia e Biofísica. Núcleo de Neurociências. Belo Horizonte, MG, BrazilUniversidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Escola de Farmácia. Departamento de Análises Clínicas. Laboratório de Imunopatologia. Ouro Preto, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Laboratório de Imunofarmacologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil. Minas Gerais, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil. Minas Gerais, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil. Minas Gerais, BrazilUniversidade Federal de Minas Gerais Departamento de Parasitologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Fisiologia e Biofísica. Núcleo de Neurociências. Belo Horizonte, MG, BrazilMalaria is second only to tuberculosis as the leading cause of morbidity and mortality as a consequence of a single infectious agent. Much of the pathology of malaria arises from the inappropriate or excessive immune response mounted by the host in an attempt to eliminate the parasite. We here report the inflammatory changes observed in the cerebral microvasculature of C57BL/6 and BALB/c mice that had been inoculated with Plasmodium berghei NK65, a lethal strain of rodent malaria. Although no neurological signs were observed in experimentally infected mice, inflammation of the cerebral microvasculature was clearly evident. Histopathological analysis demonstrated that alterations in cerebral tissue were more intense in infected C57Bl/6 mice than in infected BALB/c animals. Intravital microscopic examination of the cerebral microvasculature revealed increased leukocyte rolling and adhesion in pial venules of infected mice compared with non-infected animals. The extravasation of Evans blue dye into the cerebral parenchyma was also elevated in infected mice in comparison with their non-infected counterparts. Additionally, protein levels of TNF-α, MIG/CXCL9, MCP-1/CCL2, MIP-1α/CCL3 and RANTES/CCL5 were up-regulated in brain samples derived from infected C57Bl/6 mice. Taken together, the data reported here illustrate the complex strain-dependent relationships between leukocyte recruitment, blood brain barrier permeability and chemokine production.Experimental malariaPlasmodium bergheiNK65Intravital microscopyCerebral inflammationChemokinesMicrocirculationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8771/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALPlasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo.pdfPlasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo.pdfapplication/pdf1598176https://www.arca.fiocruz.br/bitstream/icict/8771/2/Plasmodium%20berghei%20NK65%20induces%20cerebral%20leukocyte%20recruitment%20in%20vivo.pdf25e9eb15e4c6831e3a3328dec6b0c4bbMD52TEXTPlasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo.pdf.txtPlasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo.pdf.txtExtracted texttext/plain47470https://www.arca.fiocruz.br/bitstream/icict/8771/3/Plasmodium%20berghei%20NK65%20induces%20cerebral%20leukocyte%20recruitment%20in%20vivo.pdf.txt5ebc7cf84f48a385fe69e8c5aacb0810MD53icict/87712019-06-19 10:12:52.42oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:12:52Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo: An intravital microscopic study. |
| title |
Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo: An intravital microscopic study. |
| spellingShingle |
Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo: An intravital microscopic study. Queiroz, Norinne Lacerda Experimental malaria Plasmodium berghei NK65 Intravital microscopy Cerebral inflammation Chemokines Microcirculation |
| title_short |
Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo: An intravital microscopic study. |
| title_full |
Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo: An intravital microscopic study. |
| title_fullStr |
Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo: An intravital microscopic study. |
| title_full_unstemmed |
Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo: An intravital microscopic study. |
| title_sort |
Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo: An intravital microscopic study. |
| author |
Queiroz, Norinne Lacerda |
| author_facet |
Queiroz, Norinne Lacerda Lima, Onésia Cristina Oliveira Carneiro, Cláudia Martins Vilela, Márcia Carvalho Teixeira, Antônio Lúcio Carvalho, Andrea Teixeira Araújo, Márcio Sobreira Silva Martins Filho, Olindo Assis Braga, Érika Martins Tavares, Juliana Carvalho |
| author_role |
author |
| author2 |
Lima, Onésia Cristina Oliveira Carneiro, Cláudia Martins Vilela, Márcia Carvalho Teixeira, Antônio Lúcio Carvalho, Andrea Teixeira Araújo, Márcio Sobreira Silva Martins Filho, Olindo Assis Braga, Érika Martins Tavares, Juliana Carvalho |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Queiroz, Norinne Lacerda Lima, Onésia Cristina Oliveira Carneiro, Cláudia Martins Vilela, Márcia Carvalho Teixeira, Antônio Lúcio Carvalho, Andrea Teixeira Araújo, Márcio Sobreira Silva Martins Filho, Olindo Assis Braga, Érika Martins Tavares, Juliana Carvalho |
| dc.subject.en.pt_BR.fl_str_mv |
Experimental malaria Plasmodium berghei NK65 Intravital microscopy Cerebral inflammation Chemokines Microcirculation |
| topic |
Experimental malaria Plasmodium berghei NK65 Intravital microscopy Cerebral inflammation Chemokines Microcirculation |
| description |
Universidade Federal de Minas Gerais Departamento de Parasitologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Fisiologia e Biofísica. Núcleo de Neurociências. Belo Horizonte, MG, Brazil |
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2011 |
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2011 |
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2014-11-10T13:15:46Z |
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2014-11-10T13:15:46Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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QUEIROZ, Norinne Lacerda et al. Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo: An intravital microscopic study. Acta Tropica, volume 120, fascisculo 1–2, p.31–39, out-nov. 2011. |
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https://www.arca.fiocruz.br/handle/icict/8771 |
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0001-706X 10.1016/j.actatropica.2011.04.020 |
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QUEIROZ, Norinne Lacerda et al. Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo: An intravital microscopic study. Acta Tropica, volume 120, fascisculo 1–2, p.31–39, out-nov. 2011. 0001-706X 10.1016/j.actatropica.2011.04.020 |
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Elsevier Ltda |
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Elsevier Ltda |
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