Cardiomyocyte dysfunction during the chronic phase of Chagas disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/59405 |
Resumo: | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Bioquímica e Imunologia. Laboratório de Membranas Excitáveis e Biologia Cardiovascular. Belo Horizonte, MG, Brasil. |
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Campos, Danilo RomanSales Júnior, Policarpo AdemarDuarte, Hugo LeonardoGomes, Eneas RicardoGuatimosim, SilviaRopert, CatherineGazzinelli, Ricardo TostesCruz, Jader Santos2023-07-04T17:27:56Z2023-07-04T17:27:56Z2013CAMPOS, Danilo Roman et al. Cardiomyocyte dysfunction during the chronic phase of Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 108, n. 2, p. 243-245, Apr. 2013.0074-0276https://www.arca.fiocruz.br/handle/icict/5940510.1590/0074-0276108022013019engMinistério da SaúdeCardiomyocyte dysfunction during the chronic phase of Chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Bioquímica e Imunologia. Laboratório de Membranas Excitáveis e Biologia Cardiovascular. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Bioquímica e Imunologia. Laboratório de Membranas Excitáveis e Biologia Cardiovascular. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Farmacologia. Laboratório de Sinalização Intracelular em Cardiomiócitos. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Farmacologia. Laboratório de Sinalização Intracelular em Cardiomiócitos. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Bioquímica e Imunologia. Laboratório de Membranas Excitáveis e Biologia Cardiovascular. Belo Horizonte, MG, Brasil.Chagas disease, which is caused by the parasite Trypanosoma cruzi, is an important cause of heart failure. We investigated modifications in the cellular electrophysiological and calcium-handling characteristics of an infected mouse heart during the chronic phase of the disease. The patch-clamp technique was used to record action potentials (APs) and L-type Ca2+ and transient outward K+ currents. [Ca2+](i) changes were determined using confocal microscopy. Infected ventricular cells showed prolonged APs, reduced transient outward K+ and L-type Ca2+ currents and reduced Ca2+ release from the sarcoplasmic reticulum. Thus, the chronic phase of Chagas disease is characterised by cardiomyocyte dysfunction, which could lead to heart failure.Chagas diseaseCalcium currentAction potentialPotassium currentIntracellular calciumTrypanosoma cruziinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALindex.pdfindex.pdfapplication/pdf344468https://www.arca.fiocruz.br/bitstream/icict/59405/2/index.pdfb8ccb0b1c44d17eab5eac6ee59ef7504MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/59405/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/594052023-07-06 22:22:58.961oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-07-07T01:22:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Cardiomyocyte dysfunction during the chronic phase of Chagas disease |
| title |
Cardiomyocyte dysfunction during the chronic phase of Chagas disease |
| spellingShingle |
Cardiomyocyte dysfunction during the chronic phase of Chagas disease Campos, Danilo Roman Chagas disease Calcium current Action potential Potassium current Intracellular calcium Trypanosoma cruzi |
| title_short |
Cardiomyocyte dysfunction during the chronic phase of Chagas disease |
| title_full |
Cardiomyocyte dysfunction during the chronic phase of Chagas disease |
| title_fullStr |
Cardiomyocyte dysfunction during the chronic phase of Chagas disease |
| title_full_unstemmed |
Cardiomyocyte dysfunction during the chronic phase of Chagas disease |
| title_sort |
Cardiomyocyte dysfunction during the chronic phase of Chagas disease |
| author |
Campos, Danilo Roman |
| author_facet |
Campos, Danilo Roman Sales Júnior, Policarpo Ademar Duarte, Hugo Leonardo Gomes, Eneas Ricardo Guatimosim, Silvia Ropert, Catherine Gazzinelli, Ricardo Tostes Cruz, Jader Santos |
| author_role |
author |
| author2 |
Sales Júnior, Policarpo Ademar Duarte, Hugo Leonardo Gomes, Eneas Ricardo Guatimosim, Silvia Ropert, Catherine Gazzinelli, Ricardo Tostes Cruz, Jader Santos |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Campos, Danilo Roman Sales Júnior, Policarpo Ademar Duarte, Hugo Leonardo Gomes, Eneas Ricardo Guatimosim, Silvia Ropert, Catherine Gazzinelli, Ricardo Tostes Cruz, Jader Santos |
| dc.subject.en.en_US.fl_str_mv |
Chagas disease Calcium current Action potential Potassium current Intracellular calcium Trypanosoma cruzi |
| topic |
Chagas disease Calcium current Action potential Potassium current Intracellular calcium Trypanosoma cruzi |
| description |
Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Bioquímica e Imunologia. Laboratório de Membranas Excitáveis e Biologia Cardiovascular. Belo Horizonte, MG, Brasil. |
| publishDate |
2013 |
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2013 |
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2023-07-04T17:27:56Z |
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2023-07-04T17:27:56Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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CAMPOS, Danilo Roman et al. Cardiomyocyte dysfunction during the chronic phase of Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 108, n. 2, p. 243-245, Apr. 2013. |
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https://www.arca.fiocruz.br/handle/icict/59405 |
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0074-0276 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/0074-0276108022013019 |
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CAMPOS, Danilo Roman et al. Cardiomyocyte dysfunction during the chronic phase of Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 108, n. 2, p. 243-245, Apr. 2013. 0074-0276 10.1590/0074-0276108022013019 |
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Ministério da Saúde |
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Ministério da Saúde |
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