Synthesis and antitubercular activity of new L-serinyl hydrazone derivatives
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36602 |
Resumo: | 2020-10-21 |
| id |
CRUZ_33b25a9022465f2fe4c4fbf3a63b19b4 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/36602 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Pinheiro, Alessandra CampbellKaiser, Carlos RolandNogueira, Thaís Cristina MendonçaCarvalho, Samir AquinoSilva, Edson Ferreira daFeitosa, Larisse de OliveiraHenriques, Maria das Graças Müller de OliveiraCandéa, André Luís PeixotoLourenço, Maria Cristina SilvaSouza, Marcus Vinícius Nora de2019-10-21T14:43:20Z2019-10-21T14:43:20Z2011PINHEIRO, Alessandra Campbell et al. Synthesis and antitubercular activity of new L-serinyl hydrazone derivatives. Medicinal Chemistry, v. 7, p. 611-623, 2011.1573-4064https://www.arca.fiocruz.br/handle/icict/3660210.2174/1573406117979283251875-6638engBentham Science PublishersSynthesis and antitubercular activity of new L-serinyl hydrazone derivativesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-10-21Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Química Orgânica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Química Orgânica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Química Orgânica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisas Clínicas Evandro Chagas. Departamento de Bacteriologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Química Orgânica. Rio de Janeiro, RJ, Brasil.A series of 32 L-serinyl hydrazone derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv, being also evaluated their cell viabilities in non infected and infected macrophages with Mycobacterium bovis Bacillus Calmette-Guerin (BCG). The compounds 8c, 8e, 8h and 8i, were non-cytotoxic and exhibited an important minimum inhibitory concentration (MIC) activity between 25 and 100μg/mL, which can be compared with that of the tuberculostatic drug D-cicloserine (5-20μg/mL).BCGD-cycloserineHydrazoneL-cycloserineL-serineMycobacteriumTuberculosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36602/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Pinheiro_Alessandra_etal_INI_2011.pdfve_Pinheiro_Alessandra_etal_INI_2011.pdfapplication/pdf288214https://www.arca.fiocruz.br/bitstream/icict/36602/2/ve_Pinheiro_Alessandra_etal_INI_2011.pdf35e4a13434fd89002014ff4307e73d33MD52TEXTve_Pinheiro_Alessandra_etal_INI_2011.pdf.txtve_Pinheiro_Alessandra_etal_INI_2011.pdf.txtExtracted texttext/plain51434https://www.arca.fiocruz.br/bitstream/icict/36602/3/ve_Pinheiro_Alessandra_etal_INI_2011.pdf.txt33a50d410f9d0cd728c73947fcdcc87eMD53icict/366022021-02-10 19:38:18.675oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-02-10T22:38:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Synthesis and antitubercular activity of new L-serinyl hydrazone derivatives |
| title |
Synthesis and antitubercular activity of new L-serinyl hydrazone derivatives |
| spellingShingle |
Synthesis and antitubercular activity of new L-serinyl hydrazone derivatives Pinheiro, Alessandra Campbell BCG D-cycloserine Hydrazone L-cycloserine L-serine Mycobacterium Tuberculosis |
| title_short |
Synthesis and antitubercular activity of new L-serinyl hydrazone derivatives |
| title_full |
Synthesis and antitubercular activity of new L-serinyl hydrazone derivatives |
| title_fullStr |
Synthesis and antitubercular activity of new L-serinyl hydrazone derivatives |
| title_full_unstemmed |
Synthesis and antitubercular activity of new L-serinyl hydrazone derivatives |
| title_sort |
Synthesis and antitubercular activity of new L-serinyl hydrazone derivatives |
| author |
Pinheiro, Alessandra Campbell |
| author_facet |
Pinheiro, Alessandra Campbell Kaiser, Carlos Roland Nogueira, Thaís Cristina Mendonça Carvalho, Samir Aquino Silva, Edson Ferreira da Feitosa, Larisse de Oliveira Henriques, Maria das Graças Müller de Oliveira Candéa, André Luís Peixoto Lourenço, Maria Cristina Silva Souza, Marcus Vinícius Nora de |
| author_role |
author |
| author2 |
Kaiser, Carlos Roland Nogueira, Thaís Cristina Mendonça Carvalho, Samir Aquino Silva, Edson Ferreira da Feitosa, Larisse de Oliveira Henriques, Maria das Graças Müller de Oliveira Candéa, André Luís Peixoto Lourenço, Maria Cristina Silva Souza, Marcus Vinícius Nora de |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pinheiro, Alessandra Campbell Kaiser, Carlos Roland Nogueira, Thaís Cristina Mendonça Carvalho, Samir Aquino Silva, Edson Ferreira da Feitosa, Larisse de Oliveira Henriques, Maria das Graças Müller de Oliveira Candéa, André Luís Peixoto Lourenço, Maria Cristina Silva Souza, Marcus Vinícius Nora de |
| dc.subject.en.pt_BR.fl_str_mv |
BCG D-cycloserine Hydrazone L-cycloserine L-serine Mycobacterium Tuberculosis |
| topic |
BCG D-cycloserine Hydrazone L-cycloserine L-serine Mycobacterium Tuberculosis |
| description |
2020-10-21 |
| publishDate |
2011 |
| dc.date.issued.fl_str_mv |
2011 |
| dc.date.accessioned.fl_str_mv |
2019-10-21T14:43:20Z |
| dc.date.available.fl_str_mv |
2019-10-21T14:43:20Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
PINHEIRO, Alessandra Campbell et al. Synthesis and antitubercular activity of new L-serinyl hydrazone derivatives. Medicinal Chemistry, v. 7, p. 611-623, 2011. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/36602 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1573-4064 |
| dc.identifier.doi.none.fl_str_mv |
10.2174/157340611797928325 |
| dc.identifier.eissn.none.fl_str_mv |
1875-6638 |
| identifier_str_mv |
PINHEIRO, Alessandra Campbell et al. Synthesis and antitubercular activity of new L-serinyl hydrazone derivatives. Medicinal Chemistry, v. 7, p. 611-623, 2011. 1573-4064 10.2174/157340611797928325 1875-6638 |
| url |
https://www.arca.fiocruz.br/handle/icict/36602 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Bentham Science Publishers |
| publisher.none.fl_str_mv |
Bentham Science Publishers |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/36602/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/36602/2/ve_Pinheiro_Alessandra_etal_INI_2011.pdf https://www.arca.fiocruz.br/bitstream/icict/36602/3/ve_Pinheiro_Alessandra_etal_INI_2011.pdf.txt |
| bitstream.checksum.fl_str_mv |
8a4605be74aa9ea9d79846c1fba20a33 35e4a13434fd89002014ff4307e73d33 33a50d410f9d0cd728c73947fcdcc87e |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813008840796405760 |