Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance

Nakatani, Yoshio; Opel-Reading, Helen K; Merker, Matthias; Machado, Diana; Andres, Sönke; Kumar, S Siva; Moradigaravand, Danesh; Coll, Francesc; Perdigão, João; Portugal, Isabel; Schön, Thomas; Nair, Dina; Devi, K R Uma; Kohl, Thomas A; Beckert, Patrick; Clark, Taane G; Maphalala, Gugu; Khumalo, Derrick; Diel, Roland; Klaos, Kadri; Aung, Htin Lin; Cook, Gregory M; Parkhill, Julian; Peacock, Sharon J; Swaminathan, Soumya; Viveiros, Miguel; Niemann, Stefan; Krause, Kurt L; Köser, Claudio U

Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance

Detalhes bibliográficos
Autor(a) principal:	Nakatani, Yoshio
Data de Publicação:	2017
Outros Autores:	Opel-Reading, Helen K, Merker, Matthias, Machado, Diana, Andres, Sönke, Kumar, S Siva, Moradigaravand, Danesh, Coll, Francesc, Perdigão, João, Portugal, Isabel, Schön, Thomas, Nair, Dina, Devi, K R Uma, Kohl, Thomas A, Beckert, Patrick, Clark, Taane G, Maphalala, Gugu, Khumalo, Derrick, Diel, Roland, Klaos, Kadri, Aung, Htin Lin, Cook, Gregory M, Parkhill, Julian, Peacock, Sharon J, Swaminathan, Soumya, Viveiros, Miguel, Niemann, Stefan, Krause, Kurt L, Köser, Claudio U
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo:	http://hdl.handle.net/10362/32683
Resumo:	Copyright © 2017 Nakatani et al.

Metadados do item

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repository_id_str	7160
spelling	Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistanceAlanine racemaseCycloserineMycobacterium tuberculosis complex Mycobacterium bovis Bovine tuberculosis Real-time PCRBiochemistry, Genetics and Molecular Biology (miscellaneous)Infectious DiseasesSDG 3 - Good Health and Well-beingCopyright © 2017 Nakatani et al.A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d-cycloserineInstituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)TB, HIV and opportunistic diseases and pathogens (THOP)RUNNakatani, YoshioOpel-Reading, Helen KMerker, MatthiasMachado, DianaAndres, SönkeKumar, S SivaMoradigaravand, DaneshColl, FrancescPerdigão, JoãoPortugal, IsabelSchön, ThomasNair, DinaDevi, K R UmaKohl, Thomas ABeckert, PatrickClark, Taane GMaphalala, GuguKhumalo, DerrickDiel, RolandKlaos, KadriAung, Htin LinCook, Gregory MParkhill, JulianPeacock, Sharon JSwaminathan, SoumyaViveiros, MiguelNiemann, StefanKrause, Kurt LKöser, Claudio U2018-03-16T23:19:04Z2017-122017-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10362/32683eng0066-4804PURE: 3299701https://doi.org/10.1128/AAC.01575-17info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:18:11Zoai:run.unl.pt:10362/32683Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:29:55.516347Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv	Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance
title	Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance
spellingShingle	Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance Nakatani, Yoshio Alanine racemase Cycloserine Mycobacterium tuberculosis complex Mycobacterium bovis Bovine tuberculosis Real-time PCR Biochemistry, Genetics and Molecular Biology (miscellaneous) Infectious Diseases SDG 3 - Good Health and Well-being
title_short	Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance
title_full	Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance
title_fullStr	Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance
title_full_unstemmed	Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance
title_sort	Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance
author	Nakatani, Yoshio
author_facet	Nakatani, Yoshio Opel-Reading, Helen K Merker, Matthias Machado, Diana Andres, Sönke Kumar, S Siva Moradigaravand, Danesh Coll, Francesc Perdigão, João Portugal, Isabel Schön, Thomas Nair, Dina Devi, K R Uma Kohl, Thomas A Beckert, Patrick Clark, Taane G Maphalala, Gugu Khumalo, Derrick Diel, Roland Klaos, Kadri Aung, Htin Lin Cook, Gregory M Parkhill, Julian Peacock, Sharon J Swaminathan, Soumya Viveiros, Miguel Niemann, Stefan Krause, Kurt L Köser, Claudio U
author_role	author
author2	Opel-Reading, Helen K Merker, Matthias Machado, Diana Andres, Sönke Kumar, S Siva Moradigaravand, Danesh Coll, Francesc Perdigão, João Portugal, Isabel Schön, Thomas Nair, Dina Devi, K R Uma Kohl, Thomas A Beckert, Patrick Clark, Taane G Maphalala, Gugu Khumalo, Derrick Diel, Roland Klaos, Kadri Aung, Htin Lin Cook, Gregory M Parkhill, Julian Peacock, Sharon J Swaminathan, Soumya Viveiros, Miguel Niemann, Stefan Krause, Kurt L Köser, Claudio U
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) TB, HIV and opportunistic diseases and pathogens (THOP) RUN
dc.contributor.author.fl_str_mv	Nakatani, Yoshio Opel-Reading, Helen K Merker, Matthias Machado, Diana Andres, Sönke Kumar, S Siva Moradigaravand, Danesh Coll, Francesc Perdigão, João Portugal, Isabel Schön, Thomas Nair, Dina Devi, K R Uma Kohl, Thomas A Beckert, Patrick Clark, Taane G Maphalala, Gugu Khumalo, Derrick Diel, Roland Klaos, Kadri Aung, Htin Lin Cook, Gregory M Parkhill, Julian Peacock, Sharon J Swaminathan, Soumya Viveiros, Miguel Niemann, Stefan Krause, Kurt L Köser, Claudio U
dc.subject.por.fl_str_mv	Alanine racemase Cycloserine Mycobacterium tuberculosis complex Mycobacterium bovis Bovine tuberculosis Real-time PCR Biochemistry, Genetics and Molecular Biology (miscellaneous) Infectious Diseases SDG 3 - Good Health and Well-being
topic	Alanine racemase Cycloserine Mycobacterium tuberculosis complex Mycobacterium bovis Bovine tuberculosis Real-time PCR Biochemistry, Genetics and Molecular Biology (miscellaneous) Infectious Diseases SDG 3 - Good Health and Well-being
description	Copyright © 2017 Nakatani et al.
publishDate	2017
dc.date.none.fl_str_mv	2017-12 2017-12-01T00:00:00Z 2018-03-16T23:19:04Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://hdl.handle.net/10362/32683
url	http://hdl.handle.net/10362/32683
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	0066-4804 PURE: 3299701 https://doi.org/10.1128/AAC.01575-17
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv	application/pdf application/pdf
dc.source.none.fl_str_mv	reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP
instname_str	Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance

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