Synthesis and antitubercular activity of novel amino acid derivatives

Detalhes bibliográficos
Autor(a) principal: Costa, Cristiane F. da
Data de Publicação: 2012
Outros Autores: Pinheiro, Alessandra C., Almeida, Mauro V. de, Lourenço, Maria C. S., Souza, Marcus V. N. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1111/j.1747-0285.2011.01269.x
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36435
Resumo: 2020-10-15
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spelling Costa, Cristiane F. daPinheiro, Alessandra C.Almeida, Mauro V. deLourenço, Maria C. S.Souza, Marcus V. N. de2019-10-15T12:50:25Z2019-10-15T12:50:25Z2012COSTA, Cristiane F. da et al. Synthesis and antitubercular activity of novel amino acid derivatives. Chemical Biology and Drug Design, v. 79, p. 216-222, 2012.1747-0277https://www.arca.fiocruz.br/handle/icict/3643510.1111/j.1747-0285.2011.01269.x1747-0285engWileySynthesis and antitubercular activity of novel amino acid derivativesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-10-15Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil / Universidade Federal de Juiz de Fora. Instituto de Ciências Exatas. Departamento de Química. Juiz de Fora, MG, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Universidade Federal de Juiz de Fora. Instituto de Ciências Exatas. Departamento de Química. Juiz de Fora, MG, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisas Clínicas Evandro Chagas. Departamento de Bacteriologia. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.In this work, 17 new N-acylhydrazone derivatives of amino acids have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. The compounds 8b, 8e, 8f, 9a-d, and 10c exhibited an important minimum inhibitory concentration activity between 12.5 and 50 μg/mL, which can be compared with that of the tuberculostatic drug d-cycloserine (20 μg/mL).Amino acidsCell wallHydrazonesTuberculosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36435/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Costa_Cristiane_etal_INI_2012.pdfve_Costa_Cristiane_etal_INI_2012.pdfapplication/pdf292830https://www.arca.fiocruz.br/bitstream/icict/36435/2/ve_Costa_Cristiane_etal_INI_2012.pdf33e4e32ebd4c5d657aa3a2738e1a7960MD52TEXTve_Costa_Cristiane_etal_INI_2012.pdf.txtve_Costa_Cristiane_etal_INI_2012.pdf.txtExtracted texttext/plain38995https://www.arca.fiocruz.br/bitstream/icict/36435/3/ve_Costa_Cristiane_etal_INI_2012.pdf.txt3bd35cf29fbc2bd4a8e4192f9ab33e92MD53icict/364352021-03-24 16:32:37.561oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:37Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Synthesis and antitubercular activity of novel amino acid derivatives
title Synthesis and antitubercular activity of novel amino acid derivatives
spellingShingle Synthesis and antitubercular activity of novel amino acid derivatives
Costa, Cristiane F. da
Amino acids
Cell wall
Hydrazones
Tuberculosis
title_short Synthesis and antitubercular activity of novel amino acid derivatives
title_full Synthesis and antitubercular activity of novel amino acid derivatives
title_fullStr Synthesis and antitubercular activity of novel amino acid derivatives
title_full_unstemmed Synthesis and antitubercular activity of novel amino acid derivatives
title_sort Synthesis and antitubercular activity of novel amino acid derivatives
author Costa, Cristiane F. da
author_facet Costa, Cristiane F. da
Pinheiro, Alessandra C.
Almeida, Mauro V. de
Lourenço, Maria C. S.
Souza, Marcus V. N. de
author_role author
author2 Pinheiro, Alessandra C.
Almeida, Mauro V. de
Lourenço, Maria C. S.
Souza, Marcus V. N. de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Costa, Cristiane F. da
Pinheiro, Alessandra C.
Almeida, Mauro V. de
Lourenço, Maria C. S.
Souza, Marcus V. N. de
dc.subject.en.pt_BR.fl_str_mv Amino acids
Cell wall
Hydrazones
Tuberculosis
topic Amino acids
Cell wall
Hydrazones
Tuberculosis
description 2020-10-15
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-10-15T12:50:25Z
dc.date.available.fl_str_mv 2019-10-15T12:50:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, Cristiane F. da et al. Synthesis and antitubercular activity of novel amino acid derivatives. Chemical Biology and Drug Design, v. 79, p. 216-222, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36435
dc.identifier.issn.pt_BR.fl_str_mv 1747-0277
dc.identifier.doi.none.fl_str_mv 10.1111/j.1747-0285.2011.01269.x
dc.identifier.eissn.none.fl_str_mv 1747-0285
identifier_str_mv COSTA, Cristiane F. da et al. Synthesis and antitubercular activity of novel amino acid derivatives. Chemical Biology and Drug Design, v. 79, p. 216-222, 2012.
1747-0277
10.1111/j.1747-0285.2011.01269.x
1747-0285
url https://www.arca.fiocruz.br/handle/icict/36435
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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