Late-Relapsing Hepatitis After Yellow Fever
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.3390/v12020222 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41488 |
Resumo: | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Vírus. Belo Horizonte, MG, Brazil. |
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Rezende, Izabela MaurícioPereira, Leonardo SoaresFradico, Jordana Rodrigues BarbosaXavier, Marcelo Antônio PascoalAlves, Pedro AugustoAzevedo, Ana Carolina CampiSpeziali, ElaineSantos, Lívia Zignago Moreira DosAlbuquerque, Natalia SoaresPenido, IndiaraSantos, Tayrine AraujoBom, Ana Paula Dinis AnoSilva, Andrea Marques Vieira daFernandes, Camilla BaymaCalzavara, Carlos EduardoKroon, Erna GeessienMartins Filho, Olindo AssisCarvalho, Andréa Teixeira deDrumond, Betânia Paiva2020-06-02T18:58:56Z2020-06-02T18:58:56Z2020REZENDE, Izabela Maurício et al. Late-Relapsing Hepatitis After Yellow Fever. Case Reports Viruses, v. 12, n. 2, 222, 2020.1999-4915https://www.arca.fiocruz.br/handle/icict/4148810.3390/v12020222porMDPILate-Relapsing Hepatitis After Yellow Feverinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Vírus. Belo Horizonte, MG, Brazil.Estado de Minas Gerais. Fundação Hospitalar de Minas Gerais. Hospital Eduardo de . Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Imunologia de Doenças Virais. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Imunologia de Doenças Virais. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.Estado de Minas Gerais. Fundação Hospitalar de Minas Gerais. Hospital Eduardo de . Belo Horizonte, MG, Brazil.Estado de Minas Gerais. Fundação Hospitalar de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil.Estado de Minas Gerais. Fundação Hospitalar de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil.Estado de Minas Gerais. Fundação Hospitalar de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Bio-Manguinhos Laboratório de Tecnologia Imunológica. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Bio-Manguinhos Laboratório de Tecnologia Imunológica. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Bio-Manguinhos Laboratório de Tecnologia Imunológica. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz Instituto René Rachou. Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Vírus. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Vírus. Belo Horizonte, MG, Brazil.One patient presented hyporexia, asthenia, adynamia, and jaundice two months after acute yellow fever (YF) onset; plus laboratory tests indicating hepatic cytolysis and a rebound of alanine and aspartate transaminases, and total and direct bilirubin levels. Laboratory tests discarded autoimmune hepatitis, inflammatory or metabolic liver disease, and new infections caused by hepatotropic agents. Anti-YFV IgM, IgG and neutralizing antibodies were detected in different times, but no viremia. A liver biopsy was collected three months after YF onset and tested positive for YFV antigens and wild-type YFV-RNA (364 RNA-copies/gram/liver). Transaminases and bilirubin levels remained elevated for five months, and the arresting of symptoms persisted for six months after the acute YF onset. Several serum chemokines, cytokines, and growth factors were measured. A similar immune response profile was observed in the earlier phases of the disease, followed by more pronounced changes in the later stages, when transaminases levels returned to normal. The results indicated viral persistence in the liver and continual liver cell damage three months after YF onset and reinforced the need for extended follow-ups of YF patients. Further studies to investigate the role of possible viral persistence and the immune response causing relapsing hepatitis following YF are also necessary.emerging virusflavivirushepatitisliver biopsyliver damagepersistent infectionrelapsing hepatitisviral persistenceyellow feveryellow fever virusinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/41488/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALIRR - BIO - viruses-12-00222.pdfIRR - BIO - viruses-12-00222.pdfapplication/pdf1842860https://www.arca.fiocruz.br/bitstream/icict/41488/2/IRR%20-%20BIO%20-%20viruses-12-00222.pdf8da821282e7de25bc7b07943df043e03MD52TEXTIRR - BIO - viruses-12-00222.pdf.txtIRR - BIO - viruses-12-00222.pdf.txtExtracted 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Late-Relapsing Hepatitis After Yellow Fever |
| title |
Late-Relapsing Hepatitis After Yellow Fever |
| spellingShingle |
Late-Relapsing Hepatitis After Yellow Fever Rezende, Izabela Maurício emerging virus flavivirus hepatitis liver biopsy liver damage persistent infection relapsing hepatitis viral persistence yellow fever yellow fever virus |
| title_short |
Late-Relapsing Hepatitis After Yellow Fever |
| title_full |
Late-Relapsing Hepatitis After Yellow Fever |
| title_fullStr |
Late-Relapsing Hepatitis After Yellow Fever |
| title_full_unstemmed |
Late-Relapsing Hepatitis After Yellow Fever |
| title_sort |
Late-Relapsing Hepatitis After Yellow Fever |
| author |
Rezende, Izabela Maurício |
| author_facet |
Rezende, Izabela Maurício Pereira, Leonardo Soares Fradico, Jordana Rodrigues Barbosa Xavier, Marcelo Antônio Pascoal Alves, Pedro Augusto Azevedo, Ana Carolina Campi Speziali, Elaine Santos, Lívia Zignago Moreira Dos Albuquerque, Natalia Soares Penido, Indiara Santos, Tayrine Araujo Bom, Ana Paula Dinis Ano Silva, Andrea Marques Vieira da Fernandes, Camilla Bayma Calzavara, Carlos Eduardo Kroon, Erna Geessien Martins Filho, Olindo Assis Carvalho, Andréa Teixeira de Drumond, Betânia Paiva |
| author_role |
author |
| author2 |
Pereira, Leonardo Soares Fradico, Jordana Rodrigues Barbosa Xavier, Marcelo Antônio Pascoal Alves, Pedro Augusto Azevedo, Ana Carolina Campi Speziali, Elaine Santos, Lívia Zignago Moreira Dos Albuquerque, Natalia Soares Penido, Indiara Santos, Tayrine Araujo Bom, Ana Paula Dinis Ano Silva, Andrea Marques Vieira da Fernandes, Camilla Bayma Calzavara, Carlos Eduardo Kroon, Erna Geessien Martins Filho, Olindo Assis Carvalho, Andréa Teixeira de Drumond, Betânia Paiva |
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author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rezende, Izabela Maurício Pereira, Leonardo Soares Fradico, Jordana Rodrigues Barbosa Xavier, Marcelo Antônio Pascoal Alves, Pedro Augusto Azevedo, Ana Carolina Campi Speziali, Elaine Santos, Lívia Zignago Moreira Dos Albuquerque, Natalia Soares Penido, Indiara Santos, Tayrine Araujo Bom, Ana Paula Dinis Ano Silva, Andrea Marques Vieira da Fernandes, Camilla Bayma Calzavara, Carlos Eduardo Kroon, Erna Geessien Martins Filho, Olindo Assis Carvalho, Andréa Teixeira de Drumond, Betânia Paiva |
| dc.subject.en.pt_BR.fl_str_mv |
emerging virus flavivirus hepatitis liver biopsy liver damage persistent infection relapsing hepatitis viral persistence yellow fever yellow fever virus |
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emerging virus flavivirus hepatitis liver biopsy liver damage persistent infection relapsing hepatitis viral persistence yellow fever yellow fever virus |
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Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Vírus. Belo Horizonte, MG, Brazil. |
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2020 |
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2020 |
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REZENDE, Izabela Maurício et al. Late-Relapsing Hepatitis After Yellow Fever. Case Reports Viruses, v. 12, n. 2, 222, 2020. |
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https://www.arca.fiocruz.br/handle/icict/41488 |
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1999-4915 |
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10.3390/v12020222 |
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REZENDE, Izabela Maurício et al. Late-Relapsing Hepatitis After Yellow Fever. Case Reports Viruses, v. 12, n. 2, 222, 2020. 1999-4915 10.3390/v12020222 |
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