Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros
| Main Author: | |
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| Publication Date: | 2020 |
| Other Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| Download full: | https://www.arca.fiocruz.br/handle/icict/45070 |
Summary: | Global Health Institute, Ecole Polytechnique Fédérale de Lausanne. Lausanne, Switzerland / Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University. Fort Collins, CO, United States / Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute. Basel, Switzerland. |
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Avanzi, CharlotteLecorche, EmmanuelRakotomalala, Fetra AngelotBenjak, AndrejRabenja, Fahafahantsoa RapelanoroRamarozatovo, Lala S.Cauchoix, BertrandRakoto-Andrianarivelo, MalaTió-Coma, MariaLeal-Calvo, ThiagoBusso, PhilippeBoy-Röttger, StefanieChauffour, AurélieRasamoelina, TahinamandratoAndrianarison, AinaSendrasoa, FandresenaSpencer, John S.Singh, PushpendraDashatwar, Digambar RamchandraNarang, RahulBerland, Jean-LucJarlier, VincentSalgado, Claudio G.Moraes, Milton O.Geluk, AnnemiekeRandrianantoandro, AndriamiraCambau, EmmanuelleCole, Stewart T.2020-12-22T14:19:02Z2020-12-22T14:19:02Z2020AVANZI, Charlotte et al. Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros. Frontiers in Microbiology, v. 11, Article 711, p. 1-9, May 2020.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/4507010.3389/fmicb.2020.00711engFrontiers MediaHanseníaseMycobacterium lepraeMadagascarComorosGenômicaFilogeografiaLeprosyMycobacterium lepraeMadagascarComorosGenomicsPhylogeographyPopulation Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comorosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGlobal Health Institute, Ecole Polytechnique Fédérale de Lausanne. Lausanne, Switzerland / Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University. Fort Collins, CO, United States / Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute. Basel, Switzerland.AP-HP, Hôpital Lariboisière, Service de Bactériologie, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux - Laboratoire Associé. Paris, France / Université de Paris, INSERM, IAME UMR1137. Paris, France.Centre d’Infectiologie Charles Mérieux, Université d’Antananarivo. Antananarivo, Madagascar.lobal Health Institute, Ecole Polytechnique Fédérale de Lausanne. Lausanne, Switzerland.Unité de Soin, de Formations et de Recherche de Dermatologie, University Hospital Joseph Raseta Befelatanana, Antananarivo. Madagascar.Unité de Soin, de Formations et de Recherche de Dermatologie, University Hospital Joseph Raseta Befelatanana, Antananarivo. Madagascar / Department of Medecine-Interne, University Hospital Joseph Raseta Befelatanana.Antananarivo, Madagascar.ondation Raoul Follereau. Antananarivo, Madagascar.Centre d’Infectiologie Charles Mérieux, Université d’Antananarivo. Antananarivo, Madagascar.Department of Infectious Diseases, Leiden University Medical Center. Leiden, Netherlands.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Global Health Institute, Ecole Polytechnique Fédérale de Lausanne. Lausanne, SwitzerlandGlobal Health Institute, Ecole Polytechnique Fédérale de Lausanne. Lausanne, SwitzerlandSorbonne Université, INSERM U1135, Centre d’Immunologie et des Maladies Infectieuses. CIMI-Paris, Paris, France.Centre d’Infectiologie Charles Mérieux, Université d’Antananarivo. Antananarivo, Madagascar.Unité de Soin, de Formations et de Recherche de Dermatologie, University Hospital Joseph Raseta Befelatanana. Antananarivo, Madagascar.Unité de Soin, de Formations et de Recherche de Dermatologie, University Hospital Joseph Raseta Befelatanana. Antananarivo, Madagascar.Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University. Fort Collins, CO, United States.National Institute of Research in Tribal Health (Indian Council of Medical Research). Jabalpur, India.Mahatma Gandhi Institute of Medical Sciences. Wardha, India.Mahatma Gandhi Institute of Medical Sciences. Wardha, India.Fondation Merieux. Lyon, France / CIRI, Centre International de Recherche en Infectiologie, Inserm U1111. Lyon, France.Sorbonne Université, INSERM U1135, Centre d’Immunologie et des Maladies Infectieuses, CIMI-Paris. Paris, France / AP-HP, Hôpital Pitié-Salpêtrière, Service de Bactériologie, Centre National de Référence des Mycobactéries et de la résistance des Mycobactéries aux Antituberculeux. Paris, France.Universidade Federal do Pará. Laboratório de Dermato-Imunologia. Marituba, PA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Department of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands,Programme National de Lutte Contre la Lèpre. Antananarivo, Madagascar.AP-HP, Hôpital Lariboisière, Service de Bactériologie, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux - Laboratoire Associé. Paris, France / Université de Paris, INSERM, IAME UMR1137. Paris, France.Global Health Institute, Ecole Polytechnique Fédérale de Lausanne. Lausanne, Switzerland / Institut Pasteur, Paris, France.Human settlement of Madagascar traces back to the beginning of the first millennium with the arrival of Austronesians from Southeast Asia, followed by migrations from Africa and the Middle East. Remains of these different cultural, genetic, and linguistic legacies are still present in Madagascar and other islands of the Indian Ocean. The close relationship between human migration and the introduction and spread of infectious diseases, a well-documented phenomenon, is particularly evident for the causative agent of leprosy, Mycobacterium leprae. In this study, we used whole-genome sequencing (WGS) and molecular dating to characterize the genetic background and retrace the origin of the M. leprae strains circulating in Madagascar (n = 30) and the Comoros (n = 3), two islands where leprosy is still considered a public health problem and monitored as part of a drug resistance surveillance program. Most M. leprae strains (97%) from Madagascar and Comoros belonged to a new genotype as part of branch 1, closely related to single nucleotide polymorphism (SNP) type 1D, named 1D-Malagasy. Other strains belonged to the genotype 1A (3%). We sequenced 39 strains from nine other countries, which, together with previously published genomes, amounted to 242 genomes that were used for molecular dating. Specific SNP markers for the new 1D-Malagasy genotype were used to screen samples from 11 countries and revealed this genotype to be restricted to Madagascar, with the sole exception being a strain from Malawi. The overall analysis thus ruled out a possible introduction of leprosy by the Austronesian settlers and suggests a later origin from East Africa, the Middle East, or South Asia.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45070/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALThiagoCalvo_PhyilippSusso_etal_IOC_2020.pdfThiagoCalvo_PhyilippSusso_etal_IOC_2020.pdfapplication/pdf18832670https://www.arca.fiocruz.br/bitstream/icict/45070/2/ThiagoCalvo_PhyilippSusso_etal_IOC_2020.pdf138860fafc977b87a583f0aba1eded1cMD52TEXTThiagoCalvo_PhyilippSusso_etal_IOC_2020.pdf.txtThiagoCalvo_PhyilippSusso_etal_IOC_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros |
| title |
Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros |
| spellingShingle |
Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros Avanzi, Charlotte Hanseníase Mycobacterium leprae Madagascar Comoros Genômica Filogeografia Leprosy Mycobacterium leprae Madagascar Comoros Genomics Phylogeography |
| title_short |
Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros |
| title_full |
Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros |
| title_fullStr |
Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros |
| title_full_unstemmed |
Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros |
| title_sort |
Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros |
| author |
Avanzi, Charlotte |
| author_facet |
Avanzi, Charlotte Lecorche, Emmanuel Rakotomalala, Fetra Angelot Benjak, Andrej Rabenja, Fahafahantsoa Rapelanoro Ramarozatovo, Lala S. Cauchoix, Bertrand Rakoto-Andrianarivelo, Mala Tió-Coma, Maria Leal-Calvo, Thiago Busso, Philippe Boy-Röttger, Stefanie Chauffour, Aurélie Rasamoelina, Tahinamandrato Andrianarison, Aina Sendrasoa, Fandresena Spencer, John S. Singh, Pushpendra Dashatwar, Digambar Ramchandra Narang, Rahul Berland, Jean-Luc Jarlier, Vincent Salgado, Claudio G. Moraes, Milton O. Geluk, Annemieke Randrianantoandro, Andriamira Cambau, Emmanuelle Cole, Stewart T. |
| author_role |
author |
| author2 |
Lecorche, Emmanuel Rakotomalala, Fetra Angelot Benjak, Andrej Rabenja, Fahafahantsoa Rapelanoro Ramarozatovo, Lala S. Cauchoix, Bertrand Rakoto-Andrianarivelo, Mala Tió-Coma, Maria Leal-Calvo, Thiago Busso, Philippe Boy-Röttger, Stefanie Chauffour, Aurélie Rasamoelina, Tahinamandrato Andrianarison, Aina Sendrasoa, Fandresena Spencer, John S. Singh, Pushpendra Dashatwar, Digambar Ramchandra Narang, Rahul Berland, Jean-Luc Jarlier, Vincent Salgado, Claudio G. Moraes, Milton O. Geluk, Annemieke Randrianantoandro, Andriamira Cambau, Emmanuelle Cole, Stewart T. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Avanzi, Charlotte Lecorche, Emmanuel Rakotomalala, Fetra Angelot Benjak, Andrej Rabenja, Fahafahantsoa Rapelanoro Ramarozatovo, Lala S. Cauchoix, Bertrand Rakoto-Andrianarivelo, Mala Tió-Coma, Maria Leal-Calvo, Thiago Busso, Philippe Boy-Röttger, Stefanie Chauffour, Aurélie Rasamoelina, Tahinamandrato Andrianarison, Aina Sendrasoa, Fandresena Spencer, John S. Singh, Pushpendra Dashatwar, Digambar Ramchandra Narang, Rahul Berland, Jean-Luc Jarlier, Vincent Salgado, Claudio G. Moraes, Milton O. Geluk, Annemieke Randrianantoandro, Andriamira Cambau, Emmanuelle Cole, Stewart T. |
| dc.subject.other.pt_BR.fl_str_mv |
Hanseníase Mycobacterium leprae Madagascar Comoros Genômica Filogeografia |
| topic |
Hanseníase Mycobacterium leprae Madagascar Comoros Genômica Filogeografia Leprosy Mycobacterium leprae Madagascar Comoros Genomics Phylogeography |
| dc.subject.en.pt_BR.fl_str_mv |
Leprosy Mycobacterium leprae Madagascar Comoros Genomics Phylogeography |
| description |
Global Health Institute, Ecole Polytechnique Fédérale de Lausanne. Lausanne, Switzerland / Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University. Fort Collins, CO, United States / Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute. Basel, Switzerland. |
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2020 |
| dc.date.accessioned.fl_str_mv |
2020-12-22T14:19:02Z |
| dc.date.available.fl_str_mv |
2020-12-22T14:19:02Z |
| dc.date.issued.fl_str_mv |
2020 |
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info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
AVANZI, Charlotte et al. Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros. Frontiers in Microbiology, v. 11, Article 711, p. 1-9, May 2020. |
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https://www.arca.fiocruz.br/handle/icict/45070 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1664-302X |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fmicb.2020.00711 |
| identifier_str_mv |
AVANZI, Charlotte et al. Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros. Frontiers in Microbiology, v. 11, Article 711, p. 1-9, May 2020. 1664-302X 10.3389/fmicb.2020.00711 |
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https://www.arca.fiocruz.br/handle/icict/45070 |
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eng |
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Frontiers Media |
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Frontiers Media |
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