Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros

Avanzi, Charlotte; Lecorche, Emmanuel; Rakotomalala, Fetra Angelot; Benjak, Andrej; Rabenja, Fahafahantsoa Rapelanoro; Ramarozatovo, Lala S.; Cauchoix, Bertrand; Rakoto-Andrianarivelo, Mala; Tió-Coma, Maria; Leal-Calvo, Thiago; Busso, Philippe; Boy-Röttger, Stefanie; Chauffour, Aurélie; Rasamoelina, Tahinamandrato; Andrianarison, Aina; Sendrasoa, Fandresena; Spencer, John S.; Singh, Pushpendra; Dashatwar, Digambar Ramchandra; Narang, Rahul; Berland, Jean-Luc; Jarlier, Vincent; Salgado, Claudio G.; Moraes, Milton O.; Geluk, Annemieke; Randrianantoandro, Andriamira; Cambau, Emmanuelle; Cole, Stewart T.

Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros

Detalhes bibliográficos
Autor(a) principal:	Avanzi, Charlotte
Data de Publicação:	2020
Outros Autores:	Lecorche, Emmanuel, Rakotomalala, Fetra Angelot, Benjak, Andrej, Rabenja, Fahafahantsoa Rapelanoro, Ramarozatovo, Lala S., Cauchoix, Bertrand, Rakoto-Andrianarivelo, Mala, Tió-Coma, Maria, Leal-Calvo, Thiago, Busso, Philippe, Boy-Röttger, Stefanie, Chauffour, Aurélie, Rasamoelina, Tahinamandrato, Andrianarison, Aina, Sendrasoa, Fandresena, Spencer, John S., Singh, Pushpendra, Dashatwar, Digambar Ramchandra, Narang, Rahul, Berland, Jean-Luc, Jarlier, Vincent, Salgado, Claudio G., Moraes, Milton O., Geluk, Annemieke, Randrianantoandro, Andriamira, Cambau, Emmanuelle, Cole, Stewart T.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/45070
Resumo:	Global Health Institute, Ecole Polytechnique Fédérale de Lausanne. Lausanne, Switzerland / Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University. Fort Collins, CO, United States / Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute. Basel, Switzerland.

Metadados do item

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spelling	Avanzi, CharlotteLecorche, EmmanuelRakotomalala, Fetra AngelotBenjak, AndrejRabenja, Fahafahantsoa RapelanoroRamarozatovo, Lala S.Cauchoix, BertrandRakoto-Andrianarivelo, MalaTió-Coma, MariaLeal-Calvo, ThiagoBusso, PhilippeBoy-Röttger, StefanieChauffour, AurélieRasamoelina, TahinamandratoAndrianarison, AinaSendrasoa, FandresenaSpencer, John S.Singh, PushpendraDashatwar, Digambar RamchandraNarang, RahulBerland, Jean-LucJarlier, VincentSalgado, Claudio G.Moraes, Milton O.Geluk, AnnemiekeRandrianantoandro, AndriamiraCambau, EmmanuelleCole, Stewart T.2020-12-22T14:19:02Z2020-12-22T14:19:02Z2020AVANZI, Charlotte et al. Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros. Frontiers in Microbiology, v. 11, Article 711, p. 1-9, May 2020.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/4507010.3389/fmicb.2020.00711engFrontiers MediaHanseníaseMycobacterium lepraeMadagascarComorosGenômicaFilogeografiaLeprosyMycobacterium lepraeMadagascarComorosGenomicsPhylogeographyPopulation Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comorosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGlobal Health Institute, Ecole Polytechnique Fédérale de Lausanne. Lausanne, Switzerland / Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University. Fort Collins, CO, United States / Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute. Basel, Switzerland.AP-HP, Hôpital Lariboisière, Service de Bactériologie, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux - Laboratoire Associé. Paris, France / Université de Paris, INSERM, IAME UMR1137. Paris, France.Centre d’Infectiologie Charles Mérieux, Université d’Antananarivo. Antananarivo, Madagascar.lobal Health Institute, Ecole Polytechnique Fédérale de Lausanne. Lausanne, Switzerland.Unité de Soin, de Formations et de Recherche de Dermatologie, University Hospital Joseph Raseta Befelatanana, Antananarivo. Madagascar.Unité de Soin, de Formations et de Recherche de Dermatologie, University Hospital Joseph Raseta Befelatanana, Antananarivo. Madagascar / Department of Medecine-Interne, University Hospital Joseph Raseta Befelatanana.Antananarivo, Madagascar.ondation Raoul Follereau. Antananarivo, Madagascar.Centre d’Infectiologie Charles Mérieux, Université d’Antananarivo. Antananarivo, Madagascar.Department of Infectious Diseases, Leiden University Medical Center. Leiden, Netherlands.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Global Health Institute, Ecole Polytechnique Fédérale de Lausanne. Lausanne, SwitzerlandGlobal Health Institute, Ecole Polytechnique Fédérale de Lausanne. Lausanne, SwitzerlandSorbonne Université, INSERM U1135, Centre d’Immunologie et des Maladies Infectieuses. CIMI-Paris, Paris, France.Centre d’Infectiologie Charles Mérieux, Université d’Antananarivo. Antananarivo, Madagascar.Unité de Soin, de Formations et de Recherche de Dermatologie, University Hospital Joseph Raseta Befelatanana. Antananarivo, Madagascar.Unité de Soin, de Formations et de Recherche de Dermatologie, University Hospital Joseph Raseta Befelatanana. Antananarivo, Madagascar.Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University. Fort Collins, CO, United States.National Institute of Research in Tribal Health (Indian Council of Medical Research). Jabalpur, India.Mahatma Gandhi Institute of Medical Sciences. Wardha, India.Mahatma Gandhi Institute of Medical Sciences. Wardha, India.Fondation Merieux. Lyon, France / CIRI, Centre International de Recherche en Infectiologie, Inserm U1111. Lyon, France.Sorbonne Université, INSERM U1135, Centre d’Immunologie et des Maladies Infectieuses, CIMI-Paris. Paris, France / AP-HP, Hôpital Pitié-Salpêtrière, Service de Bactériologie, Centre National de Référence des Mycobactéries et de la résistance des Mycobactéries aux Antituberculeux. Paris, France.Universidade Federal do Pará. Laboratório de Dermato-Imunologia. Marituba, PA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Department of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands,Programme National de Lutte Contre la Lèpre. Antananarivo, Madagascar.AP-HP, Hôpital Lariboisière, Service de Bactériologie, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux - Laboratoire Associé. Paris, France / Université de Paris, INSERM, IAME UMR1137. Paris, France.Global Health Institute, Ecole Polytechnique Fédérale de Lausanne. Lausanne, Switzerland / Institut Pasteur, Paris, France.Human settlement of Madagascar traces back to the beginning of the first millennium with the arrival of Austronesians from Southeast Asia, followed by migrations from Africa and the Middle East. Remains of these different cultural, genetic, and linguistic legacies are still present in Madagascar and other islands of the Indian Ocean. The close relationship between human migration and the introduction and spread of infectious diseases, a well-documented phenomenon, is particularly evident for the causative agent of leprosy, Mycobacterium leprae. In this study, we used whole-genome sequencing (WGS) and molecular dating to characterize the genetic background and retrace the origin of the M. leprae strains circulating in Madagascar (n = 30) and the Comoros (n = 3), two islands where leprosy is still considered a public health problem and monitored as part of a drug resistance surveillance program. Most M. leprae strains (97%) from Madagascar and Comoros belonged to a new genotype as part of branch 1, closely related to single nucleotide polymorphism (SNP) type 1D, named 1D-Malagasy. Other strains belonged to the genotype 1A (3%). We sequenced 39 strains from nine other countries, which, together with previously published genomes, amounted to 242 genomes that were used for molecular dating. Specific SNP markers for the new 1D-Malagasy genotype were used to screen samples from 11 countries and revealed this genotype to be restricted to Madagascar, with the sole exception being a strain from Malawi. The overall analysis thus ruled out a possible introduction of leprosy by the Austronesian settlers and suggests a later origin from East Africa, the Middle East, or South Asia.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45070/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALThiagoCalvo_PhyilippSusso_etal_IOC_2020.pdfThiagoCalvo_PhyilippSusso_etal_IOC_2020.pdfapplication/pdf18832670https://www.arca.fiocruz.br/bitstream/icict/45070/2/ThiagoCalvo_PhyilippSusso_etal_IOC_2020.pdf138860fafc977b87a583f0aba1eded1cMD52TEXTThiagoCalvo_PhyilippSusso_etal_IOC_2020.pdf.txtThiagoCalvo_PhyilippSusso_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv	Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros
title	Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros
spellingShingle	Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros Avanzi, Charlotte Hanseníase Mycobacterium leprae Madagascar Comoros Genômica Filogeografia Leprosy Mycobacterium leprae Madagascar Comoros Genomics Phylogeography
title_short	Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros
title_full	Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros
title_fullStr	Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros
title_full_unstemmed	Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros
title_sort	Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros
author	Avanzi, Charlotte
author_facet	Avanzi, Charlotte Lecorche, Emmanuel Rakotomalala, Fetra Angelot Benjak, Andrej Rabenja, Fahafahantsoa Rapelanoro Ramarozatovo, Lala S. Cauchoix, Bertrand Rakoto-Andrianarivelo, Mala Tió-Coma, Maria Leal-Calvo, Thiago Busso, Philippe Boy-Röttger, Stefanie Chauffour, Aurélie Rasamoelina, Tahinamandrato Andrianarison, Aina Sendrasoa, Fandresena Spencer, John S. Singh, Pushpendra Dashatwar, Digambar Ramchandra Narang, Rahul Berland, Jean-Luc Jarlier, Vincent Salgado, Claudio G. Moraes, Milton O. Geluk, Annemieke Randrianantoandro, Andriamira Cambau, Emmanuelle Cole, Stewart T.
author_role	author
author2	Lecorche, Emmanuel Rakotomalala, Fetra Angelot Benjak, Andrej Rabenja, Fahafahantsoa Rapelanoro Ramarozatovo, Lala S. Cauchoix, Bertrand Rakoto-Andrianarivelo, Mala Tió-Coma, Maria Leal-Calvo, Thiago Busso, Philippe Boy-Röttger, Stefanie Chauffour, Aurélie Rasamoelina, Tahinamandrato Andrianarison, Aina Sendrasoa, Fandresena Spencer, John S. Singh, Pushpendra Dashatwar, Digambar Ramchandra Narang, Rahul Berland, Jean-Luc Jarlier, Vincent Salgado, Claudio G. Moraes, Milton O. Geluk, Annemieke Randrianantoandro, Andriamira Cambau, Emmanuelle Cole, Stewart T.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Avanzi, Charlotte Lecorche, Emmanuel Rakotomalala, Fetra Angelot Benjak, Andrej Rabenja, Fahafahantsoa Rapelanoro Ramarozatovo, Lala S. Cauchoix, Bertrand Rakoto-Andrianarivelo, Mala Tió-Coma, Maria Leal-Calvo, Thiago Busso, Philippe Boy-Röttger, Stefanie Chauffour, Aurélie Rasamoelina, Tahinamandrato Andrianarison, Aina Sendrasoa, Fandresena Spencer, John S. Singh, Pushpendra Dashatwar, Digambar Ramchandra Narang, Rahul Berland, Jean-Luc Jarlier, Vincent Salgado, Claudio G. Moraes, Milton O. Geluk, Annemieke Randrianantoandro, Andriamira Cambau, Emmanuelle Cole, Stewart T.
dc.subject.other.pt_BR.fl_str_mv	Hanseníase Mycobacterium leprae Madagascar Comoros Genômica Filogeografia
topic	Hanseníase Mycobacterium leprae Madagascar Comoros Genômica Filogeografia Leprosy Mycobacterium leprae Madagascar Comoros Genomics Phylogeography
dc.subject.en.pt_BR.fl_str_mv	Leprosy Mycobacterium leprae Madagascar Comoros Genomics Phylogeography
description	Global Health Institute, Ecole Polytechnique Fédérale de Lausanne. Lausanne, Switzerland / Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University. Fort Collins, CO, United States / Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute. Basel, Switzerland.
publishDate	2020
dc.date.accessioned.fl_str_mv	2020-12-22T14:19:02Z
dc.date.available.fl_str_mv	2020-12-22T14:19:02Z
dc.date.issued.fl_str_mv	2020
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	AVANZI, Charlotte et al. Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros. Frontiers in Microbiology, v. 11, Article 711, p. 1-9, May 2020.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/45070
dc.identifier.issn.pt_BR.fl_str_mv	1664-302X
dc.identifier.doi.none.fl_str_mv	10.3389/fmicb.2020.00711
identifier_str_mv	AVANZI, Charlotte et al. Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros. Frontiers in Microbiology, v. 11, Article 711, p. 1-9, May 2020. 1664-302X 10.3389/fmicb.2020.00711
url	https://www.arca.fiocruz.br/handle/icict/45070
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Frontiers Media
publisher.none.fl_str_mv	Frontiers Media
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
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repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
_version_	1813009157060558848

Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros

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