Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/27998 |
Resumo: | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. |
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Barros, Ana Paula D. N. deTakiya, Christina M.Garzoni, Luciana R.Ferreira, Mona Lisa LealDutra, Hélio S.Chiarini, Luciana B.Meirelles, Maria NazarethBorojevic, RadovanRossi, Maria Isabel D.2018-08-08T12:20:32Z2018-08-08T12:20:32Z2010BARROS, Ana Paula D. N. de; et al. Osteoblasts and Bone Marrow Mesenchymal Stromal Cells Control Hematopoietic Stem Cell Migration and Proliferation in 3D In Vitro Model. PLoS ONE, v. 5, n.2, e9093, 13p, Feb. 2010.1932-6203https://www.arca.fiocruz.br/handle/icict/2799810.1371/journal.pone.0009093engPublic Library of ScienceOsteoblastosMedula ósseaMigração e proliferação3 DCélulas Estromais Mesenquimaiscélulas-tronco hematopoiéticasOsteoblastsBone Marrowhematopoietic stem cellsMesenchymal Stromal CellsMigration and Proliferation3 DOsteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Migration, proliferation, and differentiation of hematopoietic stem cells (HSCs) are dependent upon a complex three-dimensional (3D) bone marrow microenvironment. Although osteoblasts control the HSC pool, the subendosteal niche is complex and its cellular composition and the role of each cell population in HSC fate have not been established. In vivo models are complex and involve subtle species-specific differences, while bidimensional cultures do not reflect the 3D tissue organization. The aim of this study was to investigate in vitro the role of human bone marrow-derived mesenchymal stromal cells (BMSC) and active osteoblasts in control of migration, lodgment, and proliferation of HSCs.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27998/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALluciana_garzoni2_etal_IOC_2010.PDFluciana_garzoni2_etal_IOC_2010.PDFapplication/pdf1370646https://www.arca.fiocruz.br/bitstream/icict/27998/2/luciana_garzoni2_etal_IOC_2010.PDF601d7ef6f6591c9a11fe1276f7625da8MD52TEXTluciana_garzoni2_etal_IOC_2010.PDF.txtluciana_garzoni2_etal_IOC_2010.PDF.txtExtracted texttext/plain67097https://www.arca.fiocruz.br/bitstream/icict/27998/3/luciana_garzoni2_etal_IOC_2010.PDF.txtd6f503e28d31f105509b41d60746f5b6MD53icict/279982018-08-15 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| dc.title.pt_BR.fl_str_mv |
Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model |
| title |
Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model |
| spellingShingle |
Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model Barros, Ana Paula D. N. de Osteoblastos Medula óssea Migração e proliferação 3 D Células Estromais Mesenquimais células-tronco hematopoiéticas Osteoblasts Bone Marrow hematopoietic stem cells Mesenchymal Stromal Cells Migration and Proliferation 3 D |
| title_short |
Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model |
| title_full |
Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model |
| title_fullStr |
Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model |
| title_full_unstemmed |
Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model |
| title_sort |
Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model |
| author |
Barros, Ana Paula D. N. de |
| author_facet |
Barros, Ana Paula D. N. de Takiya, Christina M. Garzoni, Luciana R. Ferreira, Mona Lisa Leal Dutra, Hélio S. Chiarini, Luciana B. Meirelles, Maria Nazareth Borojevic, Radovan Rossi, Maria Isabel D. |
| author_role |
author |
| author2 |
Takiya, Christina M. Garzoni, Luciana R. Ferreira, Mona Lisa Leal Dutra, Hélio S. Chiarini, Luciana B. Meirelles, Maria Nazareth Borojevic, Radovan Rossi, Maria Isabel D. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barros, Ana Paula D. N. de Takiya, Christina M. Garzoni, Luciana R. Ferreira, Mona Lisa Leal Dutra, Hélio S. Chiarini, Luciana B. Meirelles, Maria Nazareth Borojevic, Radovan Rossi, Maria Isabel D. |
| dc.subject.other.pt_BR.fl_str_mv |
Osteoblastos Medula óssea Migração e proliferação 3 D Células Estromais Mesenquimais células-tronco hematopoiéticas |
| topic |
Osteoblastos Medula óssea Migração e proliferação 3 D Células Estromais Mesenquimais células-tronco hematopoiéticas Osteoblasts Bone Marrow hematopoietic stem cells Mesenchymal Stromal Cells Migration and Proliferation 3 D |
| dc.subject.en.pt_BR.fl_str_mv |
Osteoblasts Bone Marrow hematopoietic stem cells Mesenchymal Stromal Cells Migration and Proliferation 3 D |
| description |
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2010 |
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2010 |
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2018-08-08T12:20:32Z |
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2018-08-08T12:20:32Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
BARROS, Ana Paula D. N. de; et al. Osteoblasts and Bone Marrow Mesenchymal Stromal Cells Control Hematopoietic Stem Cell Migration and Proliferation in 3D In Vitro Model. PLoS ONE, v. 5, n.2, e9093, 13p, Feb. 2010. |
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https://www.arca.fiocruz.br/handle/icict/27998 |
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1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0009093 |
| identifier_str_mv |
BARROS, Ana Paula D. N. de; et al. Osteoblasts and Bone Marrow Mesenchymal Stromal Cells Control Hematopoietic Stem Cell Migration and Proliferation in 3D In Vitro Model. PLoS ONE, v. 5, n.2, e9093, 13p, Feb. 2010. 1932-6203 10.1371/journal.pone.0009093 |
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