Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/49658 |
Resumo: | Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. |
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Rossi, Átila DuqueHiga, Luiza MendonçaHerlinger, Alice LaschukRibeiro-Alves, MarceloMenezes, Mariane Talon deGiannini, Ana Lucia MoraesCardoso, Cynthia ChesterPoian, Andrea T. daTanuri, AmilcarAguiar, Renato Santana2021-11-04T00:49:57Z2021-11-04T00:49:57Z2021ROSSI, Átila Duque et al. Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes. Frontiers in cellular and infection microbiology, v. 11, p. 1-8, 20212235-2988https://www.arca.fiocruz.br/handle/icict/4965810.3389/fcimb.2021.714088engFrontiers MediaDifferential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Laboratório de Bioquímica de Vírus. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Genômica Funcional e Transdução de Sinal. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Laboratório de Bioquímica de Vírus. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Laboratório de Biologia Integrativa. Belo Horizonte, MG, Brasil.Dengue virus (DENV) is the most widespread arbovirus, responsible for a wide range of clinical manifestations, varying from self-limited illness to severe hemorrhagic fever. Dengue severity is associated with host intense proinflammatory response and monocytes have been considered one of the key cell types involved in the early steps of DENV infection and immunopathogenesis. To better understand cellular mechanisms involved in monocyte infection by DENV, we analyzed the expression levels of 754 human microRNAs in DENV-infected THP-1 cells, a human monocytic cell line. Eleven human microRNAs showed differential expression after DENV infection and gene ontology and enrichment analysis revealed biological processes potentially affected by these molecules. Five downregulated microRNAs were significantly linked to cellular response to stress, four to cell death/apoptosis, two to innate immune responses and one upregulated to vesicle mediated, TGF-β signaling, phosphatidylinositol mediated signaling, lipid metabolism process and blood coagulation.DengueGene expressionmicroRNAMonocyteVirus-hostinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/49658/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALDifferential_Marcelo_Alves_etal_INI_2021.pdfDifferential_Marcelo_Alves_etal_INI_2021.pdfapplication/pdf865133https://www.arca.fiocruz.br/bitstream/icict/49658/2/Differential_Marcelo_Alves_etal_INI_2021.pdf21a3424bdbabb79cec98a9e0448f5a2bMD52icict/496582021-11-03 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dc.title.pt_BR.fl_str_mv |
Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes |
title |
Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes |
spellingShingle |
Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes Rossi, Átila Duque Dengue Gene expression microRNA Monocyte Virus-host |
title_short |
Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes |
title_full |
Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes |
title_fullStr |
Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes |
title_full_unstemmed |
Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes |
title_sort |
Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes |
author |
Rossi, Átila Duque |
author_facet |
Rossi, Átila Duque Higa, Luiza Mendonça Herlinger, Alice Laschuk Ribeiro-Alves, Marcelo Menezes, Mariane Talon de Giannini, Ana Lucia Moraes Cardoso, Cynthia Chester Poian, Andrea T. da Tanuri, Amilcar Aguiar, Renato Santana |
author_role |
author |
author2 |
Higa, Luiza Mendonça Herlinger, Alice Laschuk Ribeiro-Alves, Marcelo Menezes, Mariane Talon de Giannini, Ana Lucia Moraes Cardoso, Cynthia Chester Poian, Andrea T. da Tanuri, Amilcar Aguiar, Renato Santana |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rossi, Átila Duque Higa, Luiza Mendonça Herlinger, Alice Laschuk Ribeiro-Alves, Marcelo Menezes, Mariane Talon de Giannini, Ana Lucia Moraes Cardoso, Cynthia Chester Poian, Andrea T. da Tanuri, Amilcar Aguiar, Renato Santana |
dc.subject.en.pt_BR.fl_str_mv |
Dengue Gene expression microRNA Monocyte Virus-host |
topic |
Dengue Gene expression microRNA Monocyte Virus-host |
description |
Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-11-04T00:49:57Z |
dc.date.available.fl_str_mv |
2021-11-04T00:49:57Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ROSSI, Átila Duque et al. Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes. Frontiers in cellular and infection microbiology, v. 11, p. 1-8, 2021 |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/49658 |
dc.identifier.issn.pt_BR.fl_str_mv |
2235-2988 |
dc.identifier.doi.none.fl_str_mv |
10.3389/fcimb.2021.714088 |
identifier_str_mv |
ROSSI, Átila Duque et al. Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes. Frontiers in cellular and infection microbiology, v. 11, p. 1-8, 2021 2235-2988 10.3389/fcimb.2021.714088 |
url |
https://www.arca.fiocruz.br/handle/icict/49658 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Frontiers Media |
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Frontiers Media |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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