Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes

Detalhes bibliográficos
Autor(a) principal: Rossi, Átila Duque
Data de Publicação: 2021
Outros Autores: Higa, Luiza Mendonça, Herlinger, Alice Laschuk, Ribeiro-Alves, Marcelo, Menezes, Mariane Talon de, Giannini, Ana Lucia Moraes, Cardoso, Cynthia Chester, Poian, Andrea T. da, Tanuri, Amilcar, Aguiar, Renato Santana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/49658
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Rossi, Átila DuqueHiga, Luiza MendonçaHerlinger, Alice LaschukRibeiro-Alves, MarceloMenezes, Mariane Talon deGiannini, Ana Lucia MoraesCardoso, Cynthia ChesterPoian, Andrea T. daTanuri, AmilcarAguiar, Renato Santana2021-11-04T00:49:57Z2021-11-04T00:49:57Z2021ROSSI, Átila Duque et al. Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes. Frontiers in cellular and infection microbiology, v. 11, p. 1-8, 20212235-2988https://www.arca.fiocruz.br/handle/icict/4965810.3389/fcimb.2021.714088engFrontiers MediaDifferential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Laboratório de Bioquímica de Vírus. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Genômica Funcional e Transdução de Sinal. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Laboratório de Bioquímica de Vírus. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Laboratório de Biologia Integrativa. Belo Horizonte, MG, Brasil.Dengue virus (DENV) is the most widespread arbovirus, responsible for a wide range of clinical manifestations, varying from self-limited illness to severe hemorrhagic fever. Dengue severity is associated with host intense proinflammatory response and monocytes have been considered one of the key cell types involved in the early steps of DENV infection and immunopathogenesis. To better understand cellular mechanisms involved in monocyte infection by DENV, we analyzed the expression levels of 754 human microRNAs in DENV-infected THP-1 cells, a human monocytic cell line. Eleven human microRNAs showed differential expression after DENV infection and gene ontology and enrichment analysis revealed biological processes potentially affected by these molecules. Five downregulated microRNAs were significantly linked to cellular response to stress, four to cell death/apoptosis, two to innate immune responses and one upregulated to vesicle mediated, TGF-β signaling, phosphatidylinositol mediated signaling, lipid metabolism process and blood coagulation.DengueGene expressionmicroRNAMonocyteVirus-hostinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/49658/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALDifferential_Marcelo_Alves_etal_INI_2021.pdfDifferential_Marcelo_Alves_etal_INI_2021.pdfapplication/pdf865133https://www.arca.fiocruz.br/bitstream/icict/49658/2/Differential_Marcelo_Alves_etal_INI_2021.pdf21a3424bdbabb79cec98a9e0448f5a2bMD52icict/496582021-11-03 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dc.title.pt_BR.fl_str_mv Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes
title Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes
spellingShingle Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes
Rossi, Átila Duque
Dengue
Gene expression
microRNA
Monocyte
Virus-host
title_short Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes
title_full Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes
title_fullStr Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes
title_full_unstemmed Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes
title_sort Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes
author Rossi, Átila Duque
author_facet Rossi, Átila Duque
Higa, Luiza Mendonça
Herlinger, Alice Laschuk
Ribeiro-Alves, Marcelo
Menezes, Mariane Talon de
Giannini, Ana Lucia Moraes
Cardoso, Cynthia Chester
Poian, Andrea T. da
Tanuri, Amilcar
Aguiar, Renato Santana
author_role author
author2 Higa, Luiza Mendonça
Herlinger, Alice Laschuk
Ribeiro-Alves, Marcelo
Menezes, Mariane Talon de
Giannini, Ana Lucia Moraes
Cardoso, Cynthia Chester
Poian, Andrea T. da
Tanuri, Amilcar
Aguiar, Renato Santana
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rossi, Átila Duque
Higa, Luiza Mendonça
Herlinger, Alice Laschuk
Ribeiro-Alves, Marcelo
Menezes, Mariane Talon de
Giannini, Ana Lucia Moraes
Cardoso, Cynthia Chester
Poian, Andrea T. da
Tanuri, Amilcar
Aguiar, Renato Santana
dc.subject.en.pt_BR.fl_str_mv Dengue
Gene expression
microRNA
Monocyte
Virus-host
topic Dengue
Gene expression
microRNA
Monocyte
Virus-host
description Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-11-04T00:49:57Z
dc.date.available.fl_str_mv 2021-11-04T00:49:57Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ROSSI, Átila Duque et al. Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes. Frontiers in cellular and infection microbiology, v. 11, p. 1-8, 2021
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49658
dc.identifier.issn.pt_BR.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2021.714088
identifier_str_mv ROSSI, Átila Duque et al. Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes. Frontiers in cellular and infection microbiology, v. 11, p. 1-8, 2021
2235-2988
10.3389/fcimb.2021.714088
url https://www.arca.fiocruz.br/handle/icict/49658
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/49658/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/49658/2/Differential_Marcelo_Alves_etal_INI_2021.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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