Association of hepatosplenic schistosomiasis with HLA-DQB1*0201
Autor(a) principal: | |
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Data de Publicação: | 1996 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7576 |
Resumo: | Harvard School of Public Health. Department of Tropical Public Health. Boston, Massachusetts |
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Secor, William EDel Corral, HelenaReis, Mitermayer Galvão dosRamos, Eduardo Antônio GonçalvesZimon, Alison EMatos, E. PeixotoReis, Eliana Almeida GomesCarmo, Theomira Mauadie de AzevedoHirayama, KenjiDavid, Roberta ADavid, John RHarn Junior, Donald A2014-05-05T13:28:56Z2014-05-05T13:28:56Z1996SECOR, E. W. et al. Association of hepatosplenic schistosomiasis with HLA-DQB1*0201. Journal of Infectious Disease, v. 174, n, 5, p. 1131-1135, 1996.0022-1899https://www.arca.fiocruz.br/handle/icict/7576engThe University of Chicago PressAssociation of hepatosplenic schistosomiasis with HLA-DQB1*0201info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHarvard School of Public Health. Department of Tropical Public Health. Boston, MassachusettsHarvard School of Public Health. Department of Tropical Public Health. Boston, MassachusettsFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Hospital Roberto Santos. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Hospital Roberto Santos. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilDepartment of Medical Zoology. Saitama Medical School. Saitama, JapanDepartment of Medical Zoology. Saitama Medical School. Saitama, JapanDepartment of Medical Zoology. Saitama Medical School. Saitama, JapanDepartment of Medical Zoology. Saitama Medical School. Saitama, JapanMajor histocompatibility class II alleles of 351 persons living in an area endemic for Schistosoma mansoni in northeastern Brazil were characterized at three loci (DRBl, DQAl, and DQBl). Contingency analyses were used to compare allele frequencies witfihigh egg excretion, proliferative response to schistosome soluble egg antigens (SEA), and occurrence of severe, biopsy-confirmed hepatosplenic disease. There were no associations of HLA-DR or DQ with egg excretion. Patients positive for DRBl*Ol, DQAl*0101, or DQBl*0501 were less likely to respond to SEA than was the overall study population. However, using stringent Bonferroni correction (multiplying P values by the number of alleles tested; P X 35), none of these associations with SEA responsiveness remained significant. Hepatosplenic disease was less likely in patients positive for DRBI*11 and was more likely in patients positive for DRBl*07 or DQBl*0201. However, only the DQBl*0201 association remained significant (odds ratio = 3.72; P < .005) following Bonferroni correction.Antígenos HLA-DQ/genéticaHepatopatias Parasitárias/imunologiaEsquistossomose mansoni/imunologiaEsplenopatias/imunologiaAdolescenteAdultoAlelosCriançaPré-EscolarCadeias beta de HLA-DQHumanosLactenteAtivação Linfocitáriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSecor EW Association of hepatosplenic....pdfSecor EW Association of hepatosplenic....pdfapplication/pdf443600https://www.arca.fiocruz.br/bitstream/icict/7576/1/Secor%20EW%20Association%20of%20hepatosplenic....pdf4b7ba0a77a08655d1a252b70e4bf21e2MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7576/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSecor EW Association of hepatosplenic....pdf.txtSecor EW Association of hepatosplenic....pdf.txtExtracted texttext/plain22319https://www.arca.fiocruz.br/bitstream/icict/7576/5/Secor%20EW%20Association%20of%20hepatosplenic....pdf.txt2c2620af8c8355a5841f9add6b8498b7MD55THUMBNAILSecor EW Association of hepatosplenic....pdf.jpgSecor EW Association of hepatosplenic....pdf.jpgGenerated Thumbnailimage/jpeg2499https://www.arca.fiocruz.br/bitstream/icict/7576/4/Secor%20EW%20Association%20of%20hepatosplenic....pdf.jpg8cff3133b1ab58bf64cb13b4fc60f13eMD54icict/75762023-03-15 14:33:18.576oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Association of hepatosplenic schistosomiasis with HLA-DQB1*0201 |
title |
Association of hepatosplenic schistosomiasis with HLA-DQB1*0201 |
spellingShingle |
Association of hepatosplenic schistosomiasis with HLA-DQB1*0201 Secor, William E Antígenos HLA-DQ/genética Hepatopatias Parasitárias/imunologia Esquistossomose mansoni/imunologia Esplenopatias/imunologia Adolescente Adulto Alelos Criança Pré-Escolar Cadeias beta de HLA-DQ Humanos Lactente Ativação Linfocitária |
title_short |
Association of hepatosplenic schistosomiasis with HLA-DQB1*0201 |
title_full |
Association of hepatosplenic schistosomiasis with HLA-DQB1*0201 |
title_fullStr |
Association of hepatosplenic schistosomiasis with HLA-DQB1*0201 |
title_full_unstemmed |
Association of hepatosplenic schistosomiasis with HLA-DQB1*0201 |
title_sort |
Association of hepatosplenic schistosomiasis with HLA-DQB1*0201 |
author |
Secor, William E |
author_facet |
Secor, William E Del Corral, Helena Reis, Mitermayer Galvão dos Ramos, Eduardo Antônio Gonçalves Zimon, Alison E Matos, E. Peixoto Reis, Eliana Almeida Gomes Carmo, Theomira Mauadie de Azevedo Hirayama, Kenji David, Roberta A David, John R Harn Junior, Donald A |
author_role |
author |
author2 |
Del Corral, Helena Reis, Mitermayer Galvão dos Ramos, Eduardo Antônio Gonçalves Zimon, Alison E Matos, E. Peixoto Reis, Eliana Almeida Gomes Carmo, Theomira Mauadie de Azevedo Hirayama, Kenji David, Roberta A David, John R Harn Junior, Donald A |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Secor, William E Del Corral, Helena Reis, Mitermayer Galvão dos Ramos, Eduardo Antônio Gonçalves Zimon, Alison E Matos, E. Peixoto Reis, Eliana Almeida Gomes Carmo, Theomira Mauadie de Azevedo Hirayama, Kenji David, Roberta A David, John R Harn Junior, Donald A |
dc.subject.decs.pt_BR.fl_str_mv |
Antígenos HLA-DQ/genética Hepatopatias Parasitárias/imunologia Esquistossomose mansoni/imunologia Esplenopatias/imunologia Adolescente Adulto Alelos Criança Pré-Escolar Cadeias beta de HLA-DQ Humanos Lactente Ativação Linfocitária |
topic |
Antígenos HLA-DQ/genética Hepatopatias Parasitárias/imunologia Esquistossomose mansoni/imunologia Esplenopatias/imunologia Adolescente Adulto Alelos Criança Pré-Escolar Cadeias beta de HLA-DQ Humanos Lactente Ativação Linfocitária |
description |
Harvard School of Public Health. Department of Tropical Public Health. Boston, Massachusetts |
publishDate |
1996 |
dc.date.issued.fl_str_mv |
1996 |
dc.date.accessioned.fl_str_mv |
2014-05-05T13:28:56Z |
dc.date.available.fl_str_mv |
2014-05-05T13:28:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SECOR, E. W. et al. Association of hepatosplenic schistosomiasis with HLA-DQB1*0201. Journal of Infectious Disease, v. 174, n, 5, p. 1131-1135, 1996. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/7576 |
dc.identifier.issn.none.fl_str_mv |
0022-1899 |
identifier_str_mv |
SECOR, E. W. et al. Association of hepatosplenic schistosomiasis with HLA-DQB1*0201. Journal of Infectious Disease, v. 174, n, 5, p. 1131-1135, 1996. 0022-1899 |
url |
https://www.arca.fiocruz.br/handle/icict/7576 |
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The University of Chicago Press |
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The University of Chicago Press |
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