Association of hepatosplenic schistosomiasis with HLA-DQB1*0201

Detalhes bibliográficos
Autor(a) principal: Secor, William E
Data de Publicação: 1996
Outros Autores: Del Corral, Helena, Reis, Mitermayer Galvão dos, Ramos, Eduardo Antônio Gonçalves, Zimon, Alison E, Matos, E. Peixoto, Reis, Eliana Almeida Gomes, Carmo, Theomira Mauadie de Azevedo, Hirayama, Kenji, David, Roberta A, David, John R, Harn Junior, Donald A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7576
Resumo: Harvard School of Public Health. Department of Tropical Public Health. Boston, Massachusetts
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spelling Secor, William EDel Corral, HelenaReis, Mitermayer Galvão dosRamos, Eduardo Antônio GonçalvesZimon, Alison EMatos, E. PeixotoReis, Eliana Almeida GomesCarmo, Theomira Mauadie de AzevedoHirayama, KenjiDavid, Roberta ADavid, John RHarn Junior, Donald A2014-05-05T13:28:56Z2014-05-05T13:28:56Z1996SECOR, E. W. et al. Association of hepatosplenic schistosomiasis with HLA-DQB1*0201. Journal of Infectious Disease, v. 174, n, 5, p. 1131-1135, 1996.0022-1899https://www.arca.fiocruz.br/handle/icict/7576engThe University of Chicago PressAssociation of hepatosplenic schistosomiasis with HLA-DQB1*0201info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHarvard School of Public Health. Department of Tropical Public Health. Boston, MassachusettsHarvard School of Public Health. Department of Tropical Public Health. Boston, MassachusettsFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Hospital Roberto Santos. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Hospital Roberto Santos. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilDepartment of Medical Zoology. Saitama Medical School. Saitama, JapanDepartment of Medical Zoology. Saitama Medical School. Saitama, JapanDepartment of Medical Zoology. Saitama Medical School. Saitama, JapanDepartment of Medical Zoology. Saitama Medical School. Saitama, JapanMajor histocompatibility class II alleles of 351 persons living in an area endemic for Schistosoma mansoni in northeastern Brazil were characterized at three loci (DRBl, DQAl, and DQBl). Contingency analyses were used to compare allele frequencies witfihigh egg excretion, proliferative response to schistosome soluble egg antigens (SEA), and occurrence of severe, biopsy-confirmed hepatosplenic disease. There were no associations of HLA-DR or DQ with egg excretion. Patients positive for DRBl*Ol, DQAl*0101, or DQBl*0501 were less likely to respond to SEA than was the overall study population. However, using stringent Bonferroni correction (multiplying P values by the number of alleles tested; P X 35), none of these associations with SEA responsiveness remained significant. Hepatosplenic disease was less likely in patients positive for DRBI*11 and was more likely in patients positive for DRBl*07 or DQBl*0201. However, only the DQBl*0201 association remained significant (odds ratio = 3.72; P < .005) following Bonferroni correction.Antígenos HLA-DQ/genéticaHepatopatias Parasitárias/imunologiaEsquistossomose mansoni/imunologiaEsplenopatias/imunologiaAdolescenteAdultoAlelosCriançaPré-EscolarCadeias beta de HLA-DQHumanosLactenteAtivação Linfocitáriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSecor EW Association of hepatosplenic....pdfSecor EW Association of hepatosplenic....pdfapplication/pdf443600https://www.arca.fiocruz.br/bitstream/icict/7576/1/Secor%20EW%20Association%20of%20hepatosplenic....pdf4b7ba0a77a08655d1a252b70e4bf21e2MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7576/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSecor EW Association of hepatosplenic....pdf.txtSecor EW Association of hepatosplenic....pdf.txtExtracted texttext/plain22319https://www.arca.fiocruz.br/bitstream/icict/7576/5/Secor%20EW%20Association%20of%20hepatosplenic....pdf.txt2c2620af8c8355a5841f9add6b8498b7MD55THUMBNAILSecor EW Association of hepatosplenic....pdf.jpgSecor EW Association of hepatosplenic....pdf.jpgGenerated Thumbnailimage/jpeg2499https://www.arca.fiocruz.br/bitstream/icict/7576/4/Secor%20EW%20Association%20of%20hepatosplenic....pdf.jpg8cff3133b1ab58bf64cb13b4fc60f13eMD54icict/75762023-03-15 14:33:18.576oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Association of hepatosplenic schistosomiasis with HLA-DQB1*0201
title Association of hepatosplenic schistosomiasis with HLA-DQB1*0201
spellingShingle Association of hepatosplenic schistosomiasis with HLA-DQB1*0201
Secor, William E
Antígenos HLA-DQ/genética
Hepatopatias Parasitárias/imunologia
Esquistossomose mansoni/imunologia
Esplenopatias/imunologia
Adolescente
Adulto
Alelos
Criança
Pré-Escolar
Cadeias beta de HLA-DQ
Humanos
Lactente
Ativação Linfocitária
title_short Association of hepatosplenic schistosomiasis with HLA-DQB1*0201
title_full Association of hepatosplenic schistosomiasis with HLA-DQB1*0201
title_fullStr Association of hepatosplenic schistosomiasis with HLA-DQB1*0201
title_full_unstemmed Association of hepatosplenic schistosomiasis with HLA-DQB1*0201
title_sort Association of hepatosplenic schistosomiasis with HLA-DQB1*0201
author Secor, William E
author_facet Secor, William E
Del Corral, Helena
Reis, Mitermayer Galvão dos
Ramos, Eduardo Antônio Gonçalves
Zimon, Alison E
Matos, E. Peixoto
Reis, Eliana Almeida Gomes
Carmo, Theomira Mauadie de Azevedo
Hirayama, Kenji
David, Roberta A
David, John R
Harn Junior, Donald A
author_role author
author2 Del Corral, Helena
Reis, Mitermayer Galvão dos
Ramos, Eduardo Antônio Gonçalves
Zimon, Alison E
Matos, E. Peixoto
Reis, Eliana Almeida Gomes
Carmo, Theomira Mauadie de Azevedo
Hirayama, Kenji
David, Roberta A
David, John R
Harn Junior, Donald A
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Secor, William E
Del Corral, Helena
Reis, Mitermayer Galvão dos
Ramos, Eduardo Antônio Gonçalves
Zimon, Alison E
Matos, E. Peixoto
Reis, Eliana Almeida Gomes
Carmo, Theomira Mauadie de Azevedo
Hirayama, Kenji
David, Roberta A
David, John R
Harn Junior, Donald A
dc.subject.decs.pt_BR.fl_str_mv Antígenos HLA-DQ/genética
Hepatopatias Parasitárias/imunologia
Esquistossomose mansoni/imunologia
Esplenopatias/imunologia
Adolescente
Adulto
Alelos
Criança
Pré-Escolar
Cadeias beta de HLA-DQ
Humanos
Lactente
Ativação Linfocitária
topic Antígenos HLA-DQ/genética
Hepatopatias Parasitárias/imunologia
Esquistossomose mansoni/imunologia
Esplenopatias/imunologia
Adolescente
Adulto
Alelos
Criança
Pré-Escolar
Cadeias beta de HLA-DQ
Humanos
Lactente
Ativação Linfocitária
description Harvard School of Public Health. Department of Tropical Public Health. Boston, Massachusetts
publishDate 1996
dc.date.issued.fl_str_mv 1996
dc.date.accessioned.fl_str_mv 2014-05-05T13:28:56Z
dc.date.available.fl_str_mv 2014-05-05T13:28:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SECOR, E. W. et al. Association of hepatosplenic schistosomiasis with HLA-DQB1*0201. Journal of Infectious Disease, v. 174, n, 5, p. 1131-1135, 1996.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7576
dc.identifier.issn.none.fl_str_mv 0022-1899
identifier_str_mv SECOR, E. W. et al. Association of hepatosplenic schistosomiasis with HLA-DQB1*0201. Journal of Infectious Disease, v. 174, n, 5, p. 1131-1135, 1996.
0022-1899
url https://www.arca.fiocruz.br/handle/icict/7576
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv The University of Chicago Press
publisher.none.fl_str_mv The University of Chicago Press
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