mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway

Detalhes bibliográficos
Autor(a) principal: Ávila, Andréa Rodrigues
Data de Publicação: 2018
Outros Autores: Cabezas-Cruz, Alexjandro, Gissot, Mathieu
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40110
Resumo: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil / UMR BIPAR. Animal Health Laboratory. ANSES. INRA. ENVA. Maisons Alfort, Cedex, France.
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spelling Ávila, Andréa RodriguesCabezas-Cruz, AlexjandroGissot, Mathieu2020-02-20T19:40:45Z2020-02-20T19:40:45Z2018ÁVILA, Andrea Rodrigues; CABEZAS-CRUZ, Alexjandro; GISSOT, Mathieu. mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway. Parasites & Vectors, v. 11, n. 62, p. 1-9, 2018.1756-3305https://www.arca.fiocruz.br/handle/icict/4011010.1186/s13071-018-2648-41756-3305porBMCApicomplexaToxoplasmaGene Expression RegulationParasitesRegulación de la Expresión GénicaParásitosRegulação da Expressão GênicaPlasmodiumCryptosporidiumParasitosmRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathwayinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil / UMR BIPAR. Animal Health Laboratory. ANSES. INRA. ENVA. Maisons Alfort, Cedex, France.UMR BIPAR. Animal Health Laboratory. ANSES. INRA. ENVA. Maisons Alfort, Cedex, France / Institute of Parasitology. Biology Center. Czech Academy of Sciences. České Budějovice, Czech Republic / Faculty of Science. University of South Bohemia. České Budějovic, Czech Republic.University of Lille. CNRS. Inserm. CHU Lille; Institut Pasteur de Lille. Centre d’Infection et d’Immunité de Lille, Lille, France.Control of gene expression is crucial for parasite survival and is the result of a series of processes that are regulated to permit fine-tuning of gene expression in response to biological changes during the life-cycle of apicomplexan parasites. Control of mRNA nuclear export is a key process in eukaryotic cells but is poorly understood in apicomplexan parasites. Here, we review recent knowledge regarding this process with an emphasis on T. gondii. We describe the presence of divergent orthologs and discuss structural and functional differences in export factors between apicomplexans and other eukaryotic lineages. Undoubtedly, the use of the CRISPR/Cas9 system in high throughput screenings associated with the discovery of mRNA nuclear export complexes by proteomic analysis will contribute to identify these divergent factors. Ligand-based or structure-based strategies may be applied to investigate the potential use of these proteins as targets for new antiprotozoal agents.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/40110/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALs13071-018-2648ok.pdfs13071-018-2648ok.pdfapplication/pdf755043https://www.arca.fiocruz.br/bitstream/icict/40110/2/s13071-018-2648ok.pdf8963c24c33398abac23df99e84c54282MD52TEXTs13071-018-2648ok.pdf.txts13071-018-2648ok.pdf.txtExtracted texttext/plain51192https://www.arca.fiocruz.br/bitstream/icict/40110/3/s13071-018-2648ok.pdf.txt1d384db218574758f45236d859906512MD53icict/401102020-02-25 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dc.title.pt_BR.fl_str_mv mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway
title mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway
spellingShingle mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway
Ávila, Andréa Rodrigues
Apicomplexa
Toxoplasma
Gene Expression Regulation
Parasites
Regulación de la Expresión Génica
Parásitos
Regulação da Expressão Gênica
Plasmodium
Cryptosporidium
Parasitos
title_short mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway
title_full mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway
title_fullStr mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway
title_full_unstemmed mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway
title_sort mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway
author Ávila, Andréa Rodrigues
author_facet Ávila, Andréa Rodrigues
Cabezas-Cruz, Alexjandro
Gissot, Mathieu
author_role author
author2 Cabezas-Cruz, Alexjandro
Gissot, Mathieu
author2_role author
author
dc.contributor.author.fl_str_mv Ávila, Andréa Rodrigues
Cabezas-Cruz, Alexjandro
Gissot, Mathieu
dc.subject.other.pt_BR.fl_str_mv Apicomplexa
Toxoplasma
topic Apicomplexa
Toxoplasma
Gene Expression Regulation
Parasites
Regulación de la Expresión Génica
Parásitos
Regulação da Expressão Gênica
Plasmodium
Cryptosporidium
Parasitos
dc.subject.en.pt_BR.fl_str_mv Gene Expression Regulation
Parasites
dc.subject.es.pt_BR.fl_str_mv Regulación de la Expresión Génica
Parásitos
dc.subject.decs.pt_BR.fl_str_mv Regulação da Expressão Gênica
Plasmodium
Cryptosporidium
Parasitos
description Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil / UMR BIPAR. Animal Health Laboratory. ANSES. INRA. ENVA. Maisons Alfort, Cedex, France.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2020-02-20T19:40:45Z
dc.date.available.fl_str_mv 2020-02-20T19:40:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ÁVILA, Andrea Rodrigues; CABEZAS-CRUZ, Alexjandro; GISSOT, Mathieu. mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway. Parasites & Vectors, v. 11, n. 62, p. 1-9, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40110
dc.identifier.issn.pt_BR.fl_str_mv 1756-3305
dc.identifier.doi.none.fl_str_mv 10.1186/s13071-018-2648-4
dc.identifier.eissn.none.fl_str_mv 1756-3305
identifier_str_mv ÁVILA, Andrea Rodrigues; CABEZAS-CRUZ, Alexjandro; GISSOT, Mathieu. mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway. Parasites & Vectors, v. 11, n. 62, p. 1-9, 2018.
1756-3305
10.1186/s13071-018-2648-4
url https://www.arca.fiocruz.br/handle/icict/40110
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/40110/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/40110/2/s13071-018-2648ok.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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