Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro

Detalhes bibliográficos
Autor(a) principal: Coutinho, P.
Data de Publicação: 2010
Outros Autores: Sandim, V., Oliveira, J. A., Alves, G., Hatagima, Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/22911
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ. Brasil.
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spelling Coutinho, P.Sandim, V.Oliveira, J. A.Alves, G.Hatagima, Ana2017-10-24T10:10:51Z2017-10-24T10:10:51Z2010COUTINHO, P. et al. Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro. Genetics and Molecular Research, v.9, n.(, p.539-544, 2010.1676-5680https://www.arca.fiocruz.br/handle/icict/22911engGliomaPolimorfismo GenéticoGliomaGluthatione S-transferasegenetic polymorphismsLack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ. Brasil.Instituto Nacional de Câncer. Laboratório de Genética Aplicada. Serviço de Hematologia. Rio de Janeiro, RJ, Brasil. / Universidade Federal do Rio de Janeiro. Departamento de Bioquímica Médica. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Serviço de Neurocirurgia. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Laboratório de Genética Aplicada. Serviço de Hematologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ. Brasil.The glutathione S-transferases (GSTs), a family of phase II isozymes, detoxify several carcinogens. Genetic variations in GSTs have been associated with increased risk for cancer due to a heritable deficiency in detoxification pathways for environmental carcinogens. Conflicting findings have been reported about the association between constitutive GST polymorphisms and gliomas in different populations. The present case-control study examined 78 patients with primary glioma and 347 controls from Rio de Janeiro. DNA was isolated from whole blood, and four genetic polymorphisms (GSTM1, GSTM3, GSTT1, and GSTP1) were determined by PCR-RFLP. The distributions of the genotypic frequencies of these polymorphisms did not differ significantly between cases and controls and were as expected by Hardy-Weinberg equilibrium (P > 0.05). Risk analysis did not show an association between GSTs and primary glioma, suggesting that these polymorphisms do not influence the risk of primary glioma, at least in this population in Rio de Janeiro, Brazil.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/22911/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALp_coutinho_etal_IOC_2010.pdfp_coutinho_etal_IOC_2010.pdfapplication/pdf207620https://www.arca.fiocruz.br/bitstream/icict/22911/2/p_coutinho_etal_IOC_2010.pdfba036b16940a11c1dc7194d56796b95bMD52TEXTp_coutinho_etal_IOC_2010.pdf.txtp_coutinho_etal_IOC_2010.pdf.txtExtracted texttext/plain17204https://www.arca.fiocruz.br/bitstream/icict/22911/3/p_coutinho_etal_IOC_2010.pdf.txtf78595637def851e403ff5f1e5a1ec3eMD53icict/229112018-08-15 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dc.title.pt_BR.fl_str_mv Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro
title Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro
spellingShingle Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro
Coutinho, P.
Glioma
Polimorfismo Genético
Glioma
Gluthatione S-transferase
genetic polymorphisms
title_short Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro
title_full Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro
title_fullStr Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro
title_full_unstemmed Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro
title_sort Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro
author Coutinho, P.
author_facet Coutinho, P.
Sandim, V.
Oliveira, J. A.
Alves, G.
Hatagima, Ana
author_role author
author2 Sandim, V.
Oliveira, J. A.
Alves, G.
Hatagima, Ana
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Coutinho, P.
Sandim, V.
Oliveira, J. A.
Alves, G.
Hatagima, Ana
dc.subject.other.pt_BR.fl_str_mv Glioma
Polimorfismo Genético
topic Glioma
Polimorfismo Genético
Glioma
Gluthatione S-transferase
genetic polymorphisms
dc.subject.en.pt_BR.fl_str_mv Glioma
Gluthatione S-transferase
genetic polymorphisms
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ. Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2017-10-24T10:10:51Z
dc.date.available.fl_str_mv 2017-10-24T10:10:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COUTINHO, P. et al. Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro. Genetics and Molecular Research, v.9, n.(, p.539-544, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/22911
dc.identifier.issn.pt_BR.fl_str_mv 1676-5680
identifier_str_mv COUTINHO, P. et al. Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro. Genetics and Molecular Research, v.9, n.(, p.539-544, 2010.
1676-5680
url https://www.arca.fiocruz.br/handle/icict/22911
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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