In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44684 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. |
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Santos, Camila C.Zhang, HuaishengBatista, Marcos M.Oliveira, Gabriel M. deDemarque, kelly C.Gomes, Natália L. da SilvaMoreira, Otacilio C.Ogungbe, Ifedayo VictorSoeiro, Maria de Nazaré C.2020-11-30T18:32:33Z2020-11-30T18:32:33Z2020SANTOS, Camila C. et al. In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis. Antimicrobial Agents and Chemotherapy, v. 64, n. 12, e01188-20, 6p, Dec. 2020.0066-4804https://www.arca.fiocruz.br/handle/icict/4468410.1128/AAC.01188-20engAmerican Society for MicrobiologyQuimioterapia experimentalLeishmaniose CutâneaAdamantylCutaneous leishmaniasisAdamantylPhenyl sulfonyl acetamideExperimental chemotherapyIn Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Jackson State University. Department of Chemistry, Physics and Atmospheric Science. Jackson, Mississippi, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia. Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia. Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Jackson State University. Department of Chemistry, Physics and Atmospheric Science. Jackson, Mississippi, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Phenotypic assay against Leishmania amazonensis in vitro and in vivo led to identification of an adamantyl-based phenyl sulfonyl acetamide (compound 1) as a promising antileishmanial agent. Compound 1 inhibited the growth of intracellular forms of L. amazonensis (50% inhibitory concentration [IC50] 4 M) and exhibited low toxicity to host cells, with a selectivity index (SI) of 125. However, in a cutaneous leishmaniasis (CL) mouse model, compound 1 did not reduce lesions and parasite load when administered as monotherapy or when given simultaneously with a suboptimal dose of miltefosine.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44684/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCamilaCSantos_MariaNSoeiro_etal_IOC__2020.pdfCamilaCSantos_MariaNSoeiro_etal_IOC__2020.pdfapplication/pdf1063329https://www.arca.fiocruz.br/bitstream/icict/44684/2/CamilaCSantos_MariaNSoeiro_etal_IOC__2020.pdfc09f945989e1e6c72bdfae359f47e3b5MD52TEXTCamilaCSantos_MariaNSoeiro_etal_IOC__2020.pdf.txtCamilaCSantos_MariaNSoeiro_etal_IOC__2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis |
title |
In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis |
spellingShingle |
In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis Santos, Camila C. Quimioterapia experimental Leishmaniose Cutânea Adamantyl Cutaneous leishmaniasis Adamantyl Phenyl sulfonyl acetamide Experimental chemotherapy |
title_short |
In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis |
title_full |
In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis |
title_fullStr |
In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis |
title_full_unstemmed |
In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis |
title_sort |
In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis |
author |
Santos, Camila C. |
author_facet |
Santos, Camila C. Zhang, Huaisheng Batista, Marcos M. Oliveira, Gabriel M. de Demarque, kelly C. Gomes, Natália L. da Silva Moreira, Otacilio C. Ogungbe, Ifedayo Victor Soeiro, Maria de Nazaré C. |
author_role |
author |
author2 |
Zhang, Huaisheng Batista, Marcos M. Oliveira, Gabriel M. de Demarque, kelly C. Gomes, Natália L. da Silva Moreira, Otacilio C. Ogungbe, Ifedayo Victor Soeiro, Maria de Nazaré C. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Camila C. Zhang, Huaisheng Batista, Marcos M. Oliveira, Gabriel M. de Demarque, kelly C. Gomes, Natália L. da Silva Moreira, Otacilio C. Ogungbe, Ifedayo Victor Soeiro, Maria de Nazaré C. |
dc.subject.other.pt_BR.fl_str_mv |
Quimioterapia experimental Leishmaniose Cutânea Adamantyl |
topic |
Quimioterapia experimental Leishmaniose Cutânea Adamantyl Cutaneous leishmaniasis Adamantyl Phenyl sulfonyl acetamide Experimental chemotherapy |
dc.subject.en.pt_BR.fl_str_mv |
Cutaneous leishmaniasis Adamantyl Phenyl sulfonyl acetamide Experimental chemotherapy |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-11-30T18:32:33Z |
dc.date.available.fl_str_mv |
2020-11-30T18:32:33Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, Camila C. et al. In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis. Antimicrobial Agents and Chemotherapy, v. 64, n. 12, e01188-20, 6p, Dec. 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/44684 |
dc.identifier.issn.pt_BR.fl_str_mv |
0066-4804 |
dc.identifier.doi.none.fl_str_mv |
10.1128/AAC.01188-20 |
identifier_str_mv |
SANTOS, Camila C. et al. In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis. Antimicrobial Agents and Chemotherapy, v. 64, n. 12, e01188-20, 6p, Dec. 2020. 0066-4804 10.1128/AAC.01188-20 |
url |
https://www.arca.fiocruz.br/handle/icict/44684 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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dc.publisher.none.fl_str_mv |
American Society for Microbiology |
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American Society for Microbiology |
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