In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis

Detalhes bibliográficos
Autor(a) principal: Santos, Camila C.
Data de Publicação: 2020
Outros Autores: Zhang, Huaisheng, Batista, Marcos M., Oliveira, Gabriel M. de, Demarque, kelly C., Gomes, Natália L. da Silva, Moreira, Otacilio C., Ogungbe, Ifedayo Victor, Soeiro, Maria de Nazaré C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44684
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
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spelling Santos, Camila C.Zhang, HuaishengBatista, Marcos M.Oliveira, Gabriel M. deDemarque, kelly C.Gomes, Natália L. da SilvaMoreira, Otacilio C.Ogungbe, Ifedayo VictorSoeiro, Maria de Nazaré C.2020-11-30T18:32:33Z2020-11-30T18:32:33Z2020SANTOS, Camila C. et al. In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis. Antimicrobial Agents and Chemotherapy, v. 64, n. 12, e01188-20, 6p, Dec. 2020.0066-4804https://www.arca.fiocruz.br/handle/icict/4468410.1128/AAC.01188-20engAmerican Society for MicrobiologyQuimioterapia experimentalLeishmaniose CutâneaAdamantylCutaneous leishmaniasisAdamantylPhenyl sulfonyl acetamideExperimental chemotherapyIn Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Jackson State University. Department of Chemistry, Physics and Atmospheric Science. Jackson, Mississippi, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia. Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia. Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Jackson State University. Department of Chemistry, Physics and Atmospheric Science. Jackson, Mississippi, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Phenotypic assay against Leishmania amazonensis in vitro and in vivo led to identification of an adamantyl-based phenyl sulfonyl acetamide (compound 1) as a promising antileishmanial agent. Compound 1 inhibited the growth of intracellular forms of L. amazonensis (50% inhibitory concentration [IC50] 4 M) and exhibited low toxicity to host cells, with a selectivity index (SI) of 125. However, in a cutaneous leishmaniasis (CL) mouse model, compound 1 did not reduce lesions and parasite load when administered as monotherapy or when given simultaneously with a suboptimal dose of miltefosine.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44684/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCamilaCSantos_MariaNSoeiro_etal_IOC__2020.pdfCamilaCSantos_MariaNSoeiro_etal_IOC__2020.pdfapplication/pdf1063329https://www.arca.fiocruz.br/bitstream/icict/44684/2/CamilaCSantos_MariaNSoeiro_etal_IOC__2020.pdfc09f945989e1e6c72bdfae359f47e3b5MD52TEXTCamilaCSantos_MariaNSoeiro_etal_IOC__2020.pdf.txtCamilaCSantos_MariaNSoeiro_etal_IOC__2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis
title In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis
spellingShingle In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis
Santos, Camila C.
Quimioterapia experimental
Leishmaniose Cutânea
Adamantyl
Cutaneous leishmaniasis
Adamantyl
Phenyl sulfonyl acetamide
Experimental chemotherapy
title_short In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis
title_full In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis
title_fullStr In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis
title_full_unstemmed In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis
title_sort In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis
author Santos, Camila C.
author_facet Santos, Camila C.
Zhang, Huaisheng
Batista, Marcos M.
Oliveira, Gabriel M. de
Demarque, kelly C.
Gomes, Natália L. da Silva
Moreira, Otacilio C.
Ogungbe, Ifedayo Victor
Soeiro, Maria de Nazaré C.
author_role author
author2 Zhang, Huaisheng
Batista, Marcos M.
Oliveira, Gabriel M. de
Demarque, kelly C.
Gomes, Natália L. da Silva
Moreira, Otacilio C.
Ogungbe, Ifedayo Victor
Soeiro, Maria de Nazaré C.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Camila C.
Zhang, Huaisheng
Batista, Marcos M.
Oliveira, Gabriel M. de
Demarque, kelly C.
Gomes, Natália L. da Silva
Moreira, Otacilio C.
Ogungbe, Ifedayo Victor
Soeiro, Maria de Nazaré C.
dc.subject.other.pt_BR.fl_str_mv Quimioterapia experimental
Leishmaniose Cutânea
Adamantyl
topic Quimioterapia experimental
Leishmaniose Cutânea
Adamantyl
Cutaneous leishmaniasis
Adamantyl
Phenyl sulfonyl acetamide
Experimental chemotherapy
dc.subject.en.pt_BR.fl_str_mv Cutaneous leishmaniasis
Adamantyl
Phenyl sulfonyl acetamide
Experimental chemotherapy
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-11-30T18:32:33Z
dc.date.available.fl_str_mv 2020-11-30T18:32:33Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, Camila C. et al. In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis. Antimicrobial Agents and Chemotherapy, v. 64, n. 12, e01188-20, 6p, Dec. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44684
dc.identifier.issn.pt_BR.fl_str_mv 0066-4804
dc.identifier.doi.none.fl_str_mv 10.1128/AAC.01188-20
identifier_str_mv SANTOS, Camila C. et al. In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis. Antimicrobial Agents and Chemotherapy, v. 64, n. 12, e01188-20, 6p, Dec. 2020.
0066-4804
10.1128/AAC.01188-20
url https://www.arca.fiocruz.br/handle/icict/44684
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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