Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis

Detalhes bibliográficos
Autor(a) principal: Araujo, Vanessa Carneiro Pereira
Data de Publicação: 2015
Outros Autores: Fukutani, Kiyoshi Ferreira, Oshiro, Elisa Teruya, Rodrigues, Patrik Oening, Rizk, Yasmin Silva, Carollo, Carlos Alexandre, Arruda, Carla Cardozo Pinto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15877
Resumo: CAPES
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spelling Araujo, Vanessa Carneiro PereiraFukutani, Kiyoshi FerreiraOshiro, Elisa TeruyaRodrigues, Patrik OeningRizk, Yasmin SilvaCarollo, Carlos AlexandreArruda, Carla Cardozo Pinto2016-09-21T13:33:17Z2016-09-21T13:33:17Z2015ARAUJO, V. C. P. et al. Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis. Experimental Parasitology, v. 157, p. 138e144, 2015.0014-4894https://www.arca.fiocruz.br/handle/icict/1587710.1016/j.exppara.2015.07.010CAPESUniversidade Federal de Mato Grosso do Sul. Centro de Ciências Biológicas e da Saúde. Laboratório de Parasitologia Humana. Campo Grande, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, BrasilUniversidade Federal de Mato Grosso do Sul. Centro de Ciências Biológicas e da Saúde. Laboratório de Parasitologia Humana. Campo Grande, MG, BrasilUniversidade Federal de Mato Grosso do Sul. Centro de Ciências Biol ogicas e da Saúde. Laboratório de Tecnologia Farmacêutica. Campo Grande, MG, BrasilUniversidade Federal de Mato Grosso do Sul. Centro de Ciências Biológicas e da Saúde. Laboratório de Parasitologia Humana. Campo Grande, MG, BrasilUniversidade Federal de Mato Grosso do Sul. Centro de Ciências Biolóogicas e da Saúde. Laborat ório de Produtos Naturais e Espectrometria de Massas e LaPNEM. Campo Grande, MG, BrasilUniversidade Federal de Mato Grosso do Sul. Centro de Ciências Biológicas e da Saúde. Laboratório de Parasitologia Humana. Campo Grande, MG, BrasilHRS/J Hairless mice have been investigated as an experimental model in cutaneous leishmaniasis induced by Leishmania (Leishmania) amazonensis. The animals were inoculated with 10(6) promastigotes into the right hind footpad and the course of infection was followed up for 30, 60 and 90 days. BALB/c mice were infected and used as control. Hairless mice were susceptible to L. (L.) amazonensis infection and a progressive increase in number of parasites and footpad thickness was detected over time. Signals of dissemination and visceralization were confirmed by the presence of parasite in the draining lymph node of lesion and spleen, at different times post infection. IL-10 gene expression evaluated by RT-PCR was significantly higher in Hairless mice at 60 days post infection, corroborating the pattern of susceptibility. These results point this inbred strain as a promising susceptible model for the study of experimental infection induced by L. (L.) amazonensis. This model would allow the use of other infection sites that minimize secondary interference and best monitoring the skin lesion, as in the case of in vivo assays of potential drugs for LT.engElsevierLeishmaniose CutaneaInfecção ExperimentalHRS/J ratoCutaneous leishmaniasisExperimental infectionHRS/J mouseHairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15877/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAraujo VCP Hairless mice as an....pdfAraujo VCP Hairless mice as 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dc.title.pt_BR.fl_str_mv Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis
title Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis
spellingShingle Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis
Araujo, Vanessa Carneiro Pereira
Leishmaniose Cutanea
Infecção Experimental
HRS/J rato
Cutaneous leishmaniasis
Experimental infection
HRS/J mouse
title_short Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis
title_full Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis
title_fullStr Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis
title_full_unstemmed Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis
title_sort Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis
author Araujo, Vanessa Carneiro Pereira
author_facet Araujo, Vanessa Carneiro Pereira
Fukutani, Kiyoshi Ferreira
Oshiro, Elisa Teruya
Rodrigues, Patrik Oening
Rizk, Yasmin Silva
Carollo, Carlos Alexandre
Arruda, Carla Cardozo Pinto
author_role author
author2 Fukutani, Kiyoshi Ferreira
Oshiro, Elisa Teruya
Rodrigues, Patrik Oening
Rizk, Yasmin Silva
Carollo, Carlos Alexandre
Arruda, Carla Cardozo Pinto
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Araujo, Vanessa Carneiro Pereira
Fukutani, Kiyoshi Ferreira
Oshiro, Elisa Teruya
Rodrigues, Patrik Oening
Rizk, Yasmin Silva
Carollo, Carlos Alexandre
Arruda, Carla Cardozo Pinto
dc.subject.other.pt_BR.fl_str_mv Leishmaniose Cutanea
Infecção Experimental
HRS/J rato
topic Leishmaniose Cutanea
Infecção Experimental
HRS/J rato
Cutaneous leishmaniasis
Experimental infection
HRS/J mouse
dc.subject.en.pt_BR.fl_str_mv Cutaneous leishmaniasis
Experimental infection
HRS/J mouse
description CAPES
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-09-21T13:33:17Z
dc.date.available.fl_str_mv 2016-09-21T13:33:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAUJO, V. C. P. et al. Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis. Experimental Parasitology, v. 157, p. 138e144, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15877
dc.identifier.issn.pt_BR.fl_str_mv 0014-4894
dc.identifier.doi.none.fl_str_mv 10.1016/j.exppara.2015.07.010
identifier_str_mv ARAUJO, V. C. P. et al. Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis. Experimental Parasitology, v. 157, p. 138e144, 2015.
0014-4894
10.1016/j.exppara.2015.07.010
url https://www.arca.fiocruz.br/handle/icict/15877
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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