Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15877 |
Resumo: | CAPES |
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Araujo, Vanessa Carneiro PereiraFukutani, Kiyoshi FerreiraOshiro, Elisa TeruyaRodrigues, Patrik OeningRizk, Yasmin SilvaCarollo, Carlos AlexandreArruda, Carla Cardozo Pinto2016-09-21T13:33:17Z2016-09-21T13:33:17Z2015ARAUJO, V. C. P. et al. Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis. Experimental Parasitology, v. 157, p. 138e144, 2015.0014-4894https://www.arca.fiocruz.br/handle/icict/1587710.1016/j.exppara.2015.07.010CAPESUniversidade Federal de Mato Grosso do Sul. Centro de Ciências Biológicas e da Saúde. Laboratório de Parasitologia Humana. Campo Grande, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, BrasilUniversidade Federal de Mato Grosso do Sul. Centro de Ciências Biológicas e da Saúde. Laboratório de Parasitologia Humana. Campo Grande, MG, BrasilUniversidade Federal de Mato Grosso do Sul. Centro de Ciências Biol ogicas e da Saúde. Laboratório de Tecnologia Farmacêutica. Campo Grande, MG, BrasilUniversidade Federal de Mato Grosso do Sul. Centro de Ciências Biológicas e da Saúde. Laboratório de Parasitologia Humana. Campo Grande, MG, BrasilUniversidade Federal de Mato Grosso do Sul. Centro de Ciências Biolóogicas e da Saúde. Laborat ório de Produtos Naturais e Espectrometria de Massas e LaPNEM. Campo Grande, MG, BrasilUniversidade Federal de Mato Grosso do Sul. Centro de Ciências Biológicas e da Saúde. Laboratório de Parasitologia Humana. Campo Grande, MG, BrasilHRS/J Hairless mice have been investigated as an experimental model in cutaneous leishmaniasis induced by Leishmania (Leishmania) amazonensis. The animals were inoculated with 10(6) promastigotes into the right hind footpad and the course of infection was followed up for 30, 60 and 90 days. BALB/c mice were infected and used as control. Hairless mice were susceptible to L. (L.) amazonensis infection and a progressive increase in number of parasites and footpad thickness was detected over time. Signals of dissemination and visceralization were confirmed by the presence of parasite in the draining lymph node of lesion and spleen, at different times post infection. IL-10 gene expression evaluated by RT-PCR was significantly higher in Hairless mice at 60 days post infection, corroborating the pattern of susceptibility. These results point this inbred strain as a promising susceptible model for the study of experimental infection induced by L. (L.) amazonensis. This model would allow the use of other infection sites that minimize secondary interference and best monitoring the skin lesion, as in the case of in vivo assays of potential drugs for LT.engElsevierLeishmaniose CutaneaInfecção ExperimentalHRS/J ratoCutaneous leishmaniasisExperimental infectionHRS/J mouseHairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15877/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAraujo VCP Hairless mice as an....pdfAraujo VCP Hairless mice as 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14:33:58.504oai:www.arca.fiocruz.br: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ório 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dc.title.pt_BR.fl_str_mv |
Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis |
title |
Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis |
spellingShingle |
Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis Araujo, Vanessa Carneiro Pereira Leishmaniose Cutanea Infecção Experimental HRS/J rato Cutaneous leishmaniasis Experimental infection HRS/J mouse |
title_short |
Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis |
title_full |
Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis |
title_fullStr |
Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis |
title_full_unstemmed |
Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis |
title_sort |
Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis |
author |
Araujo, Vanessa Carneiro Pereira |
author_facet |
Araujo, Vanessa Carneiro Pereira Fukutani, Kiyoshi Ferreira Oshiro, Elisa Teruya Rodrigues, Patrik Oening Rizk, Yasmin Silva Carollo, Carlos Alexandre Arruda, Carla Cardozo Pinto |
author_role |
author |
author2 |
Fukutani, Kiyoshi Ferreira Oshiro, Elisa Teruya Rodrigues, Patrik Oening Rizk, Yasmin Silva Carollo, Carlos Alexandre Arruda, Carla Cardozo Pinto |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Araujo, Vanessa Carneiro Pereira Fukutani, Kiyoshi Ferreira Oshiro, Elisa Teruya Rodrigues, Patrik Oening Rizk, Yasmin Silva Carollo, Carlos Alexandre Arruda, Carla Cardozo Pinto |
dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose Cutanea Infecção Experimental HRS/J rato |
topic |
Leishmaniose Cutanea Infecção Experimental HRS/J rato Cutaneous leishmaniasis Experimental infection HRS/J mouse |
dc.subject.en.pt_BR.fl_str_mv |
Cutaneous leishmaniasis Experimental infection HRS/J mouse |
description |
CAPES |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2016-09-21T13:33:17Z |
dc.date.available.fl_str_mv |
2016-09-21T13:33:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ARAUJO, V. C. P. et al. Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis. Experimental Parasitology, v. 157, p. 138e144, 2015. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/15877 |
dc.identifier.issn.pt_BR.fl_str_mv |
0014-4894 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.exppara.2015.07.010 |
identifier_str_mv |
ARAUJO, V. C. P. et al. Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis. Experimental Parasitology, v. 157, p. 138e144, 2015. 0014-4894 10.1016/j.exppara.2015.07.010 |
url |
https://www.arca.fiocruz.br/handle/icict/15877 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
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Elsevier |
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