CAT -21A>T variant alters hydroxyurea pharmacokinetic parameters in Brazilian children with sickle cell anemia

Detalhes bibliográficos
Autor(a) principal: Yahouédéhou, Sètondji Cocou Modeste Alexandre
Data de Publicação: 2022
Outros Autores: Neres, Joelma Santana dos Santos, Moraes, Natalia Valadares de, Azeredo, Francine Johansson, Fiuza, Luciana Magalhães, Guarda, Caroline Conceição da, Valverde, Suéllen Pinheiro Carvalho, Santiago, Rayra Pereira, Lyra, Isa Menezes, Adorno, Elisângela Vitória, Fonseca, Ananda Freitas, Godoy, Ana Leonor, Gonçalves, Marilda Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/60886
Resumo: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Brasil (CAPES).
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spelling Yahouédéhou, Sètondji Cocou Modeste AlexandreNeres, Joelma Santana dos SantosMoraes, Natalia Valadares deAzeredo, Francine JohanssonFiuza, Luciana MagalhãesGuarda, Caroline Conceição daValverde, Suéllen Pinheiro CarvalhoSantiago, Rayra PereiraLyra, Isa MenezesAdorno, Elisângela VitóriaFonseca, Ananda FreitasGodoy, Ana LeonorGonçalves, Marilda Souza2023-10-24T13:12:58Z2023-10-24T13:12:58Z2022YAHOUEDEHOU, Sètondji Cocou Modeste Alexandre et al. CAT -21A>T variant alters hydroxyurea pharmacokinetic parameters in Brazilian children with sickle cell anemia. Annals of Case Reports, v. 7, n. 4, p. 1-9, 2022.2574-7754https://www.arca.fiocruz.br/handle/icict/6088610.29011/25747754.100920Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Brasil (CAPES).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisas em Anemia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Center for Pharmacometrics and Systems Pharmacology. Department of Pharmaceutics. College of Pharmacy. University of Florida. Florida, USA.Center for Pharmacometrics and Systems Pharmacology. Department of Pharmaceutics. College of Pharmacy. University of Florida. Florida, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisas em Anemia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil/ Universidade Salvador. Curso de Medicina, Escola de Ciências da Saúde e Bem-Estar. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisas em Anemia. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Toxicologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Toxicologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisas em Anemia. Salvador, BA, Brasil.This study investigated the effects of the CAT -21A>T (rs7943316) variant on pharmacokinetic (PK) parameters in sickle cell anemia (SCA) children undergoing HU therapy. Plasma HU concentration of 12 SCA children was quantified using an HPLC/MS. Hematological and biochemical parameters were assessed by electronic methods, and polymorphisms were investigated by PCR-RFLP. The mean HU oral clearance was 40 ± 16 L/h, while HU Cmax and AUC0-inf were 9998.25 ± 4023.02 ng/mL and 22605.46 ± 10041.57 ng*h/mL, respectively. The heterozygote (CAT -21AT) genotype was found in 07 (58.33%) children, while the variant (CAT -21TT) genotype was found in 03 (25%) of them. Association analyses showed that children with the variant genotype had increased HU clearance and decreased HU Cmax, using codominant and recessive genetic models. Moreover, the multivariate linear regression analysis confirmed the associations between the variant CAT -21T allele in homozygous and HU clearance increase and Cmax decrease. In summary, data showed a lower HU plasma exposure in Brazilian SCA children. Interestingly, we observed the association of CAT -21A>T variant with alterations in crucial HU PK parameters, suggesting that it may be a potential genetic marker related to HU PK.engGavin PublishersAnemia falciformeHidroxiureiaGatoVarianteParâmetros farmacocinéticosSickle cell anemiaHydroxyureaCatVariantPharmacokinetic parametersAnemia FalciformeHidroxiureiaFelisCAT -21A>T variant alters hydroxyurea pharmacokinetic parameters in Brazilian children with sickle cell anemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60886/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALYahouédéhou, S. C. M. A. - CAT-21AT Variant-Alters Hydroxyurea Pharmacokinetic Parameters in Brazilian Children with Sickle CellAnemia.pdfYahouédéhou, S. C. M. A. - CAT-21AT Variant-Alters Hydroxyurea Pharmacokinetic Parameters in Brazilian Children with Sickle CellAnemia.pdfapplication/pdf1095294https://www.arca.fiocruz.br/bitstream/icict/60886/2/Yahou%c3%a9d%c3%a9hou%2c%20S.%20C.%20M.%20A.%20-%20CAT-21AT%20Variant-Alters%20Hydroxyurea%20Pharmacokinetic%20Parameters%20in%20Brazilian%20Children%20with%20Sickle%20CellAnemia.pdf0db856defec22e73ba50a1a365080910MD52icict/608862023-10-24 10:12:59.887oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-10-24T13:12:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv CAT -21A>T variant alters hydroxyurea pharmacokinetic parameters in Brazilian children with sickle cell anemia
title CAT -21A>T variant alters hydroxyurea pharmacokinetic parameters in Brazilian children with sickle cell anemia
spellingShingle CAT -21A>T variant alters hydroxyurea pharmacokinetic parameters in Brazilian children with sickle cell anemia
Yahouédéhou, Sètondji Cocou Modeste Alexandre
Anemia falciforme
Hidroxiureia
Gato
Variante
Parâmetros farmacocinéticos
Sickle cell anemia
Hydroxyurea
Cat
Variant
Pharmacokinetic parameters
Anemia Falciforme
Hidroxiureia
Felis
title_short CAT -21A>T variant alters hydroxyurea pharmacokinetic parameters in Brazilian children with sickle cell anemia
title_full CAT -21A>T variant alters hydroxyurea pharmacokinetic parameters in Brazilian children with sickle cell anemia
title_fullStr CAT -21A>T variant alters hydroxyurea pharmacokinetic parameters in Brazilian children with sickle cell anemia
title_full_unstemmed CAT -21A>T variant alters hydroxyurea pharmacokinetic parameters in Brazilian children with sickle cell anemia
title_sort CAT -21A>T variant alters hydroxyurea pharmacokinetic parameters in Brazilian children with sickle cell anemia
author Yahouédéhou, Sètondji Cocou Modeste Alexandre
author_facet Yahouédéhou, Sètondji Cocou Modeste Alexandre
Neres, Joelma Santana dos Santos
Moraes, Natalia Valadares de
Azeredo, Francine Johansson
Fiuza, Luciana Magalhães
Guarda, Caroline Conceição da
Valverde, Suéllen Pinheiro Carvalho
Santiago, Rayra Pereira
Lyra, Isa Menezes
Adorno, Elisângela Vitória
Fonseca, Ananda Freitas
Godoy, Ana Leonor
Gonçalves, Marilda Souza
author_role author
author2 Neres, Joelma Santana dos Santos
Moraes, Natalia Valadares de
Azeredo, Francine Johansson
Fiuza, Luciana Magalhães
Guarda, Caroline Conceição da
Valverde, Suéllen Pinheiro Carvalho
Santiago, Rayra Pereira
Lyra, Isa Menezes
Adorno, Elisângela Vitória
Fonseca, Ananda Freitas
Godoy, Ana Leonor
Gonçalves, Marilda Souza
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Yahouédéhou, Sètondji Cocou Modeste Alexandre
Neres, Joelma Santana dos Santos
Moraes, Natalia Valadares de
Azeredo, Francine Johansson
Fiuza, Luciana Magalhães
Guarda, Caroline Conceição da
Valverde, Suéllen Pinheiro Carvalho
Santiago, Rayra Pereira
Lyra, Isa Menezes
Adorno, Elisângela Vitória
Fonseca, Ananda Freitas
Godoy, Ana Leonor
Gonçalves, Marilda Souza
dc.subject.other.en_US.fl_str_mv Anemia falciforme
Hidroxiureia
Gato
Variante
Parâmetros farmacocinéticos
topic Anemia falciforme
Hidroxiureia
Gato
Variante
Parâmetros farmacocinéticos
Sickle cell anemia
Hydroxyurea
Cat
Variant
Pharmacokinetic parameters
Anemia Falciforme
Hidroxiureia
Felis
dc.subject.en.en_US.fl_str_mv Sickle cell anemia
Hydroxyurea
Cat
Variant
Pharmacokinetic parameters
dc.subject.decs.en_US.fl_str_mv Anemia Falciforme
Hidroxiureia
Felis
description Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Brasil (CAPES).
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-10-24T13:12:58Z
dc.date.available.fl_str_mv 2023-10-24T13:12:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv YAHOUEDEHOU, Sètondji Cocou Modeste Alexandre et al. CAT -21A>T variant alters hydroxyurea pharmacokinetic parameters in Brazilian children with sickle cell anemia. Annals of Case Reports, v. 7, n. 4, p. 1-9, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/60886
dc.identifier.issn.en_US.fl_str_mv 2574-7754
dc.identifier.doi.none.fl_str_mv 10.29011/25747754.100920
identifier_str_mv YAHOUEDEHOU, Sètondji Cocou Modeste Alexandre et al. CAT -21A>T variant alters hydroxyurea pharmacokinetic parameters in Brazilian children with sickle cell anemia. Annals of Case Reports, v. 7, n. 4, p. 1-9, 2022.
2574-7754
10.29011/25747754.100920
url https://www.arca.fiocruz.br/handle/icict/60886
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Gavin Publishers
publisher.none.fl_str_mv Gavin Publishers
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/60886/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/60886/2/Yahou%c3%a9d%c3%a9hou%2c%20S.%20C.%20M.%20A.%20-%20CAT-21AT%20Variant-Alters%20Hydroxyurea%20Pharmacokinetic%20Parameters%20in%20Brazilian%20Children%20with%20Sickle%20CellAnemia.pdf
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