Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/34775 |
Resumo: | 1- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (470959/2014-2 and 405595/2016-6 to MSG). http://www.cnpq.br/and 2- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 to SCMAY, RPS, and SPC. |
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Yahouédéhou, Sètondji Cocou Modeste AlexandreGuarda, Caroline Conceição daFigueiredo, Camylla Vilas BoasSantiago, Rayra PereiraCarvalho, Suellen PinheiroFiuza, Luciana MagalhãesNdidi, Uche SamuelOliveira, Rodrigo MotaCarvalho, Magda Oliveira SeixasNascimento, Valma Maria LopesRocha, Larissa CarneiroLyra, Isa MenezesAdorno, Elisângela VitóriaGoncalves, Marilda Souza2019-08-13T16:32:26Z2019-08-13T16:32:26Z2019YAHOUÉDÉHOU, Sètondji Cocou Modeste Alexandre et al. Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia. Plos One, v. 14, n. 7, p. 1-13, 2019.1932-6203https://www.arca.fiocruz.br/handle/icict/3477510.1371/journal.pone.02180401- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (470959/2014-2 and 405595/2016-6 to MSG). http://www.cnpq.br/and 2- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 to SCMAY, RPS, and SPC.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Ahmadu Bello University. Department of Biochemistry. Zaria, Nigeria.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Hospital Universitário Prof. Edgard Santos. Salvador, BA, Brasil.Fundação de Hematologia e Hemoterapia da Bahia. Salvador, BA, Brasil.Fundação de Hematologia e Hemoterapia da Bahia. Salvador, BA, Brasil.Fundação de Hematologia e Hemoterapia da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and inflammatory parameters in children with sickle cell anemia (SCA) in association with βS haplotype and α-thalassemia. We included 22 children with SCA who were followed for an average of 14.5 months. Laboratory parameters were assessed by electronic methods, and molecular analysis was investigated by PCR-RFLP and allele-specific PCR. Results showed significant increases in hemoglobin, HbF, hematocrit, MCV, MCH, glucose, HDL-C and albumin levels, as well as significant decreases in MCHC and AST levels, WBC, neutrophils, eosinophils, lymphocytes and reticulocytes, in children during HU therapy. HbF levels were positively correlated with hemoglobin, hematocrit, MCV and total protein, yet negatively correlated with MCHC, RDW, AAT and AST during HU therapy (p<0.05). Children who carried the Central African Republic haplotype, in response to HU therapy, presented significant increases in hemoglobin, hematocrit, triglycerides and uric acid levels, as well as significant decreases in MCHC, AST and direct bilirubin levels, WBC, neutrophils, eosinophils, lymphocytes and reticulocytes. Those with the Benin haplotype presented increases in HbF and albumin levels, and a reduction in platelet counts (p<0.05). Children with α-thalassemia presented decreased ALT during HU use, while those without this deletion presented increases in hemoglobin, hematocrit, MCV, MCH, HDL-C and albumin, as well as decreases in MCHC, neutrophils, lymphocytes, reticulocytes and AST (p<0.05). Hence, regardless of its use in association with βS haplotypes or α-thalassemia, HU seems to be linked to alterations in hemolytic, inflammatory, hepatic, lipid and glycemic profiles.engPublic Library of ScienceHidroxiureiaBiomarcadoresTalasemia alfaAnemia FalciformeCriançasHydroxyureaBiomarkersAlpha-ThalassemiaAnemia Sickle CellChildrenHydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/34775/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALYahouedehou, M.C.S Hydroxyurea alters.pdfYahouedehou, M.C.S Hydroxyurea 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| dc.title.pt_BR.fl_str_mv |
Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia |
| title |
Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia |
| spellingShingle |
Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia Yahouédéhou, Sètondji Cocou Modeste Alexandre Hidroxiureia Biomarcadores Talasemia alfa Anemia Falciforme Crianças Hydroxyurea Biomarkers Alpha-Thalassemia Anemia Sickle Cell Children |
| title_short |
Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia |
| title_full |
Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia |
| title_fullStr |
Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia |
| title_full_unstemmed |
Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia |
| title_sort |
Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia |
| author |
Yahouédéhou, Sètondji Cocou Modeste Alexandre |
| author_facet |
Yahouédéhou, Sètondji Cocou Modeste Alexandre Guarda, Caroline Conceição da Figueiredo, Camylla Vilas Boas Santiago, Rayra Pereira Carvalho, Suellen Pinheiro Fiuza, Luciana Magalhães Ndidi, Uche Samuel Oliveira, Rodrigo Mota Carvalho, Magda Oliveira Seixas Nascimento, Valma Maria Lopes Rocha, Larissa Carneiro Lyra, Isa Menezes Adorno, Elisângela Vitória Goncalves, Marilda Souza |
| author_role |
author |
| author2 |
Guarda, Caroline Conceição da Figueiredo, Camylla Vilas Boas Santiago, Rayra Pereira Carvalho, Suellen Pinheiro Fiuza, Luciana Magalhães Ndidi, Uche Samuel Oliveira, Rodrigo Mota Carvalho, Magda Oliveira Seixas Nascimento, Valma Maria Lopes Rocha, Larissa Carneiro Lyra, Isa Menezes Adorno, Elisângela Vitória Goncalves, Marilda Souza |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Yahouédéhou, Sètondji Cocou Modeste Alexandre Guarda, Caroline Conceição da Figueiredo, Camylla Vilas Boas Santiago, Rayra Pereira Carvalho, Suellen Pinheiro Fiuza, Luciana Magalhães Ndidi, Uche Samuel Oliveira, Rodrigo Mota Carvalho, Magda Oliveira Seixas Nascimento, Valma Maria Lopes Rocha, Larissa Carneiro Lyra, Isa Menezes Adorno, Elisângela Vitória Goncalves, Marilda Souza |
| dc.subject.other.pt_BR.fl_str_mv |
Hidroxiureia Biomarcadores Talasemia alfa Anemia Falciforme Crianças |
| topic |
Hidroxiureia Biomarcadores Talasemia alfa Anemia Falciforme Crianças Hydroxyurea Biomarkers Alpha-Thalassemia Anemia Sickle Cell Children |
| dc.subject.en.pt_BR.fl_str_mv |
Hydroxyurea Biomarkers Alpha-Thalassemia Anemia Sickle Cell Children |
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1- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (470959/2014-2 and 405595/2016-6 to MSG). http://www.cnpq.br/and 2- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 to SCMAY, RPS, and SPC. |
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2019 |
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2019-08-13T16:32:26Z |
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2019-08-13T16:32:26Z |
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2019 |
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YAHOUÉDÉHOU, Sètondji Cocou Modeste Alexandre et al. Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia. Plos One, v. 14, n. 7, p. 1-13, 2019. |
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https://www.arca.fiocruz.br/handle/icict/34775 |
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1932-6203 |
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10.1371/journal.pone.0218040 |
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YAHOUÉDÉHOU, Sètondji Cocou Modeste Alexandre et al. Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia. Plos One, v. 14, n. 7, p. 1-13, 2019. 1932-6203 10.1371/journal.pone.0218040 |
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