Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters

Detalhes bibliográficos
Autor(a) principal: Yahouédéhou, Sètondji Cocou Modeste Alexandre
Data de Publicação: 2018
Outros Autores: Carvalho, Magda Oliveira Seixas, Oliveira, Rodrigo Mota, Santiago, Rayra Pereira, Guarda, Caroline Conceição da, Carvalho, Suellen Pinheiro, Ferreira, Júnia Raquel Dutra, Aleluia, Milena Magalhães, Adorno, Elisângela Vitória, Gonçalves, Marilda de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/26444
Resumo: Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil
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spelling Yahouédéhou, Sètondji Cocou Modeste AlexandreCarvalho, Magda Oliveira SeixasOliveira, Rodrigo MotaSantiago, Rayra PereiraGuarda, Caroline Conceição daCarvalho, Suellen PinheiroFerreira, Júnia Raquel DutraAleluia, Milena MagalhãesAdorno, Elisângela VitóriaGonçalves, Marilda de Souza2018-05-15T14:16:24Z2018-05-15T14:16:24Z2018YAHOUÉDÉHOU, S. C. M. A. et al. Sickle anemia patients in use of hydroxyurea: association between polymorphisms in genes encoding metabolizing drug enzymes and laboratory parameters. Disease Markers, article ID 6105691, 2018.0278-0240https://www.arca.fiocruz.br/handle/icict/2644410.1155/2018/6105691engHindawi Publishing CorporationAnemia falciformePolimorfismosEnzimasHidroxiuréiaHumanosAnemia SicklePolymorphismsEnzymesHydroxyureaHumansSickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parametersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, BrasilThis study investigated associations between SNPs in genes encoding metabolizing drug enzymes and laboratory parameters in sickle cell anemia patients under hydroxyurea (SCA-HU+). We evaluated hematologic and biochemical parameters by electronic methods and SNPs by PCR-RFLP and multiplex PCR in 35 SCA-HU+ patients and 67 SCA-HU- patients. The HbS, total cholesterol, lactate dehydrogenase, aspartate aminotransferase, total bilirubin and fractions levels, and leukocyte, eosinophil, monocyte, and erythroblast counts were reduced in SCA-HU+ patients (p < 0.05). Moreover, they presented higher HbF, C-reactive protein, and ferritin levels and elevated MCH and MCV values (p < 0.05). Genotype frequencies of variants GA + AA of MPO -463G>A and c1c2 + c2c2 of CYP2E1 -1293G>C/-1053C>T were higher in SCA-HU+ patients (p < 0.05). Independent associations were found between the variant A allele and lower total cholesterol, between c2 allele and low alpha-1 antitrypsin and between the null GSTT1 variant and high indirect and total bilirubin in SCA-HU+ patients. In SCA-HU- patients, independent associations were found between the variant A allele and high uric acid and between c2 allele and high urea. Our results suggest that SNPs MPO -463G>A, CYP2E1 -1293G>C/-1053C>T, and GSTT1 can be associated with alterations in lipid, inflammatory, renal, hemolytic, and hepatic profiles. However, further studies are needed to elucidate these associations.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26444/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALYahouédéhou SC Sickle Cell Anemia Patients....pdfYahouédéhou SC Sickle Cell Anemia Patients....pdfapplication/pdf1569037https://www.arca.fiocruz.br/bitstream/icict/26444/2/Yahou%c3%a9d%c3%a9hou%20SC%20Sickle%20Cell%20Anemia%20Patients....pdf927e424328f30b9d6847ca56d8cc70b6MD52TEXTYahouédéhou SC Sickle Cell Anemia Patients....pdf.txtYahouédéhou SC Sickle Cell Anemia Patients....pdf.txtExtracted texttext/plain50085https://www.arca.fiocruz.br/bitstream/icict/26444/3/Yahou%c3%a9d%c3%a9hou%20SC%20Sickle%20Cell%20Anemia%20Patients....pdf.txt562369acd387a171f23f57228c9bae0aMD53icict/264442023-03-15 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dc.title.pt_BR.fl_str_mv Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters
title Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters
spellingShingle Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters
Yahouédéhou, Sètondji Cocou Modeste Alexandre
Anemia falciforme
Polimorfismos
Enzimas
Hidroxiuréia
Humanos
Anemia Sickle
Polymorphisms
Enzymes
Hydroxyurea
Humans
title_short Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters
title_full Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters
title_fullStr Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters
title_full_unstemmed Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters
title_sort Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters
author Yahouédéhou, Sètondji Cocou Modeste Alexandre
author_facet Yahouédéhou, Sètondji Cocou Modeste Alexandre
Carvalho, Magda Oliveira Seixas
Oliveira, Rodrigo Mota
Santiago, Rayra Pereira
Guarda, Caroline Conceição da
Carvalho, Suellen Pinheiro
Ferreira, Júnia Raquel Dutra
Aleluia, Milena Magalhães
Adorno, Elisângela Vitória
Gonçalves, Marilda de Souza
author_role author
author2 Carvalho, Magda Oliveira Seixas
Oliveira, Rodrigo Mota
Santiago, Rayra Pereira
Guarda, Caroline Conceição da
Carvalho, Suellen Pinheiro
Ferreira, Júnia Raquel Dutra
Aleluia, Milena Magalhães
Adorno, Elisângela Vitória
Gonçalves, Marilda de Souza
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Yahouédéhou, Sètondji Cocou Modeste Alexandre
Carvalho, Magda Oliveira Seixas
Oliveira, Rodrigo Mota
Santiago, Rayra Pereira
Guarda, Caroline Conceição da
Carvalho, Suellen Pinheiro
Ferreira, Júnia Raquel Dutra
Aleluia, Milena Magalhães
Adorno, Elisângela Vitória
Gonçalves, Marilda de Souza
dc.subject.other.pt_BR.fl_str_mv Anemia falciforme
Polimorfismos
Enzimas
Hidroxiuréia
Humanos
topic Anemia falciforme
Polimorfismos
Enzimas
Hidroxiuréia
Humanos
Anemia Sickle
Polymorphisms
Enzymes
Hydroxyurea
Humans
dc.subject.en.pt_BR.fl_str_mv Anemia Sickle
Polymorphisms
Enzymes
Hydroxyurea
Humans
description Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-05-15T14:16:24Z
dc.date.available.fl_str_mv 2018-05-15T14:16:24Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv YAHOUÉDÉHOU, S. C. M. A. et al. Sickle anemia patients in use of hydroxyurea: association between polymorphisms in genes encoding metabolizing drug enzymes and laboratory parameters. Disease Markers, article ID 6105691, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/26444
dc.identifier.issn.pt_BR.fl_str_mv 0278-0240
dc.identifier.doi.none.fl_str_mv 10.1155/2018/6105691
identifier_str_mv YAHOUÉDÉHOU, S. C. M. A. et al. Sickle anemia patients in use of hydroxyurea: association between polymorphisms in genes encoding metabolizing drug enzymes and laboratory parameters. Disease Markers, article ID 6105691, 2018.
0278-0240
10.1155/2018/6105691
url https://www.arca.fiocruz.br/handle/icict/26444
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/26444/1/license.txt
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