CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23217 |
Resumo: | A infecção por citomegalovírus humano (CMVH) é a principal causa de morbidade em receptores de transplante renal. Este estudo pretende investigar se a expressão de CD64 em polimorfonucleares (PMN) é útil para a detecção de infecção por CMVH em 11 receptores renais durante 60 dias. Do total de pacientes, nove foram positivos para antigenemia pp65 e para CMVH por reação em cadeia da polimerase quantitativa (qPCR), todos apresentando neutrófilos circulantes que expressam CD64 3-4 semanas antes do pico de antigenemia pp65. Esses resultados sugerem que a quantificação de PMN CD64 em conjunto com a antigenemia pp65 pode ser útil para o diagnóstico precoce de HCMV no pós-transplante. |
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Carvalho, Fabiana R.Rosário, Natalia F.Souza, Cintia F.Schmitz, VeronicaPinto, Fabiana A.Velarde, Luis Guillermo C.Lugon, Jocemir RonaldoAlmeida, Jorge R.Silva, Andrea Alice da2017-11-16T14:07:22Z2017-11-16T14:07:22Z2017CARVALHO, Fabiana R. et al. CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantation. J Bras Patol Med Lab, v. 53, n. 2, p. 119-123, April 2017.1676-2444https://www.arca.fiocruz.br/handle/icict/232171678-4774A infecção por citomegalovírus humano (CMVH) é a principal causa de morbidade em receptores de transplante renal. Este estudo pretende investigar se a expressão de CD64 em polimorfonucleares (PMN) é útil para a detecção de infecção por CMVH em 11 receptores renais durante 60 dias. Do total de pacientes, nove foram positivos para antigenemia pp65 e para CMVH por reação em cadeia da polimerase quantitativa (qPCR), todos apresentando neutrófilos circulantes que expressam CD64 3-4 semanas antes do pico de antigenemia pp65. Esses resultados sugerem que a quantificação de PMN CD64 em conjunto com a antigenemia pp65 pode ser útil para o diagnóstico precoce de HCMV no pós-transplante.Human cytomegalovirus (HCMV) infection is the main cause of morbidity in kidney transplant recipients. This study aims to investigate if CD64 expression on polymorphonuclear (PMN) cells is useful for the detection of HCMV infection in eleven kidney recipients during sixty days. From the total patients, nine were positive for both pp65 antigenemia and HCMV by quantitative polymerase chain reaction (qPCR), all of which had circulating neutrophils expressing CD64 3-4 weeks prior to pp65 antigenemia peak. These results suggest that quantification of PMN CD64 together with pp65 antigenemia could be useful for the early diagnosis of HCMV after transplantation.Universidade Federal Fluminense. Niterói, RJ, Brasil.Universidade Federal Fluminense. Niterói, RJ, Brasil.Universidade Federal Fluminense. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Universidade Federal Fluminense. Niterói, RJ, Brasil.Universidade Federal Fluminense. Niterói, RJ, Brasil.Universidade Federal Fluminense. Niterói, RJ, Brasil.Universidade Federal Fluminense. Niterói, RJ, Brasil.Universidade Federal Fluminense. Niterói, RJ, Brasil.engSociedade Brasileira de Patologia Clínicacitomegalovírusreceptores de IgGtransplante de rimneutrófiloscytomegalovirusIgG receptorskidney transplantatneutrophilsCD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantationCD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantation |
| dc.title.alternative.pt_BR.fl_str_mv |
CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantation |
| title |
CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantation |
| spellingShingle |
CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantation Carvalho, Fabiana R. citomegalovírus receptores de IgG transplante de rim neutrófilos cytomegalovirus IgG receptors kidney transplantat neutrophils |
| title_short |
CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantation |
| title_full |
CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantation |
| title_fullStr |
CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantation |
| title_full_unstemmed |
CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantation |
| title_sort |
CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantation |
| author |
Carvalho, Fabiana R. |
| author_facet |
Carvalho, Fabiana R. Rosário, Natalia F. Souza, Cintia F. Schmitz, Veronica Pinto, Fabiana A. Velarde, Luis Guillermo C. Lugon, Jocemir Ronaldo Almeida, Jorge R. Silva, Andrea Alice da |
| author_role |
author |
| author2 |
Rosário, Natalia F. Souza, Cintia F. Schmitz, Veronica Pinto, Fabiana A. Velarde, Luis Guillermo C. Lugon, Jocemir Ronaldo Almeida, Jorge R. Silva, Andrea Alice da |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carvalho, Fabiana R. Rosário, Natalia F. Souza, Cintia F. Schmitz, Veronica Pinto, Fabiana A. Velarde, Luis Guillermo C. Lugon, Jocemir Ronaldo Almeida, Jorge R. Silva, Andrea Alice da |
| dc.subject.other.pt_BR.fl_str_mv |
citomegalovírus receptores de IgG transplante de rim neutrófilos |
| topic |
citomegalovírus receptores de IgG transplante de rim neutrófilos cytomegalovirus IgG receptors kidney transplantat neutrophils |
| dc.subject.en.pt_BR.fl_str_mv |
cytomegalovirus IgG receptors kidney transplantat neutrophils |
| description |
A infecção por citomegalovírus humano (CMVH) é a principal causa de morbidade em receptores de transplante renal. Este estudo pretende investigar se a expressão de CD64 em polimorfonucleares (PMN) é útil para a detecção de infecção por CMVH em 11 receptores renais durante 60 dias. Do total de pacientes, nove foram positivos para antigenemia pp65 e para CMVH por reação em cadeia da polimerase quantitativa (qPCR), todos apresentando neutrófilos circulantes que expressam CD64 3-4 semanas antes do pico de antigenemia pp65. Esses resultados sugerem que a quantificação de PMN CD64 em conjunto com a antigenemia pp65 pode ser útil para o diagnóstico precoce de HCMV no pós-transplante. |
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2017 |
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2017-11-16T14:07:22Z |
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2017-11-16T14:07:22Z |
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2017 |
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CARVALHO, Fabiana R. et al. CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantation. J Bras Patol Med Lab, v. 53, n. 2, p. 119-123, April 2017. |
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https://www.arca.fiocruz.br/handle/icict/23217 |
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1676-2444 |
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1678-4774 |
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CARVALHO, Fabiana R. et al. CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantation. J Bras Patol Med Lab, v. 53, n. 2, p. 119-123, April 2017. 1676-2444 1678-4774 |
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