Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease

Detalhes bibliográficos
Autor(a) principal: Azeredo, Elzinandes L.
Data de Publicação: 2006
Outros Autores: Zagne, Sonia M. O., Alvarenga, Allan R., Nogueira, Rita Maria R., Kubelka, Claire F., Pinto, Luzia M. de Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33356
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
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spelling Azeredo, Elzinandes L.Zagne, Sonia M. O.Alvarenga, Allan R.Nogueira, Rita Maria R.Kubelka, Claire F.Pinto, Luzia M. de Oliveira2019-06-04T13:23:56Z2019-06-04T13:23:56Z2006AZEREDO, Elzinandes L. et al. Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 4, p. 437-449, June 2006.0074-0276https://www.arca.fiocruz.br/handle/icict/3335610.1590/S0074-027620060004000161678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzDengueAtivação de linfócitos de pacientesDenguePatients lymphocytes activationActivated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Universidade Federal Fluminense. Hospital Universitário Antonio Pedro. Departamento de Clínica Médica. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.The immune mechanisms involved in dengue fever and dengue hemorrhagic/dengue shock syndrome are not well understood. The ex vivo activation status of immune cells during the dengue disease in patients was examined. CD4 and CD8 T cells were reduced during the acute phase. Interestingly, CD8 T cells co-expressing activation marker HLA-DR, Q, P, and cytolytic granule protein-Tia-1 were significantly higher in dengue patients than in controls. Detection of adhesion molecules indicated that in dengue patients the majority of T cells (CD4 and CD8) express the activation/memory phenotype, characterized as CD44HIGH and lack the expression of the naïve cell marker, CD62LLOW. Also, the levels of T cells co-expressing ICAM-1 (CD54), VLA-4, and LFA-1 (CD11a) were significantly increased. CD8 T lymphocytes expressed predominantly low levels of anti-apoptotic molecule Bcl-2 in the acute phase, possibly leading to the exhibition of a phenotype of activated/effector cells. Circulating levels of IL-18, TGF-β1 and sICAM-1 were significantly elevated in dengue patients. Early activation events occur during acute dengue infection which might contribute to viral clearance. Differences in expression of adhesion molecules among CD4 and CD8 T cells might underlie the selective extravasation of these subsets from blood circulation into lymphoid organs and/or tissues. In addition, activated CD8 T cells would be more susceptible to apoptosis as shown by the alteration in Bcl-2 expression. Cytokines such as IL-18, TGF-β1, and sICAM-1 may be contributing by either stimulating or suppressing the adaptative immune response, during dengue infection, thereby perhaps establishing a relationship with disease severity.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33356/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALluzia_pinto_etal_IOC_2006.pdfluzia_pinto_etal_IOC_2006.pdfapplication/pdf793324https://www.arca.fiocruz.br/bitstream/icict/33356/2/luzia_pinto_etal_IOC_2006.pdf8078321e7d2a98af228648c9122844cfMD52TEXTluzia_pinto_etal_IOC_2006.pdf.txtluzia_pinto_etal_IOC_2006.pdf.txtExtracted texttext/plain57971https://www.arca.fiocruz.br/bitstream/icict/33356/3/luzia_pinto_etal_IOC_2006.pdf.txtcbd7389727d652f5e2813b452d556822MD53icict/333562019-06-05 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dc.title.pt_BR.fl_str_mv Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease
title Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease
spellingShingle Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease
Azeredo, Elzinandes L.
Dengue
Ativação de linfócitos de pacientes
Dengue
Patients lymphocytes activation
title_short Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease
title_full Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease
title_fullStr Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease
title_full_unstemmed Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease
title_sort Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease
author Azeredo, Elzinandes L.
author_facet Azeredo, Elzinandes L.
Zagne, Sonia M. O.
Alvarenga, Allan R.
Nogueira, Rita Maria R.
Kubelka, Claire F.
Pinto, Luzia M. de Oliveira
author_role author
author2 Zagne, Sonia M. O.
Alvarenga, Allan R.
Nogueira, Rita Maria R.
Kubelka, Claire F.
Pinto, Luzia M. de Oliveira
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Azeredo, Elzinandes L.
Zagne, Sonia M. O.
Alvarenga, Allan R.
Nogueira, Rita Maria R.
Kubelka, Claire F.
Pinto, Luzia M. de Oliveira
dc.subject.other.pt_BR.fl_str_mv Dengue
Ativação de linfócitos de pacientes
topic Dengue
Ativação de linfócitos de pacientes
Dengue
Patients lymphocytes activation
dc.subject.en.pt_BR.fl_str_mv Dengue
Patients lymphocytes activation
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2019-06-04T13:23:56Z
dc.date.available.fl_str_mv 2019-06-04T13:23:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AZEREDO, Elzinandes L. et al. Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 4, p. 437-449, June 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33356
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02762006000400016
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv AZEREDO, Elzinandes L. et al. Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 4, p. 437-449, June 2006.
0074-0276
10.1590/S0074-02762006000400016
1678-8060
url https://www.arca.fiocruz.br/handle/icict/33356
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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