HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23632 |
Resumo: | Fundaçao Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil. |
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Alencar, Liciana Xavier Eurico deBraga-Neto, Ulisses de MendonçaNascimento, Eduardo José Moura doCordeiro, Marli TenórioSilva, Ana MariaBrito, Carlos Alexandre Antunes deSilva, Maria da Paz Carvalho daGil, Laura Helena Vega GonzalesMontenegro, Silvia Maria LucenaMarques, Ernesto Torres de Azevedo2017-12-13T12:13:41Z2017-12-13T12:13:41Z2013ALENCAR, L. Xavier Eurico de et al. HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population. Journal of Tropical Medicine, v. 2013, p. 648475, 2013.1687-9686https://www.arca.fiocruz.br/handle/icict/2363210.1155/2013/648475engJean-Paul GonzalezDengueBrasilepidemiologiaDoenças Endêmicas, prevenção & controle.DengueBrazilepidemiologyEndemic Diseases, prevention & controlestudos transversaisVírus da dengueDengueprevenção & controleInfecção por Vírus da DengueHumanosVírus da DenguegenéticaVírus da DenguevirologiaBrasilepidemiologiaDengue GravecomplicaçõesVírus da DengueclassificaçãoDNAFemininoMasculinoÍndice de Gravidade de DoençaDengue GravediagnósticoHLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundaçao Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.Texas A&M University. Station College Station. Department of Electrical Engineering. Texas, USA.University of Pittsburgh. Center for Vaccine Research. Department of Infectious Diseases and Microbiology. Pittsburgh, PA, USA.Fundaçao Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil / Secretaria de Saúde do Estado de Pernambuco. Central Laboratory of Public Health. Recife, PE, Brazil.Fundaçao Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.Universidade Federal de Pernambuco. Hospital das Clínicas. Clínica Médica. Recife, PE, Brazil.Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Bioquímica e Biofísica. Recife, PE, Brazil.Fundaçao Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.Fundaçao Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil / University of Pittsburgh. Center for Vaccine Research. Department of Infectious Diseases and Microbiology. Pittsburgh, PA, USA.Human leukocyte antigen (HLA) alleles have been correlated with susceptibility or resistance to severe dengue; however, few immunogenetic studies have been performed in Latin American (LA) populations. We have conducted immunogenetic studies of HLA class I and II alleles in a cohort of 187 patients with DENV-3 infection and confirmed clinical diagnosis of either severe dengue, known as dengue hemorrhagic fever (DHF), or the less severe form, dengue fever (DF), in Recife, Pernambuco, Brazil. An association analysis was performed using Fisher's association test, with odds ratios (ORs) calculated using conditional maximum likelihood estimates. HLA-B∗44 (P = 0.047, OR = 2.025, 95% CI = 0.97-4.24) was found to be associated with increased susceptibility to DHF in response to DENV-3 infection. In addition, HLA-B∗07 (P = 0.048, OR = 0.501, one-sided 95% CI = 0-0.99) and HLA-DR∗13 (P = 0.028, OR = 0.511, one-sided 95% CI = 0-0.91) were found to be associated with resistance to secondary dengue infection by DENV-3. These results suggest that HLA-B∗44 supertype alleles and their respective T-cell responses might be involved in susceptibility to severe dengue infections, whereas the HLA-B∗07 supertype alleles and DR∗13 might be involved in cross-dengue serotype immunity.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83092https://www.arca.fiocruz.br/bitstream/icict/23632/1/license.txt447f2497af1ef5cf99b5c07f6fa18dceMD51ORIGINALart. HLA-B∗44 - alencar.pdfart. 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| dc.title.pt_BR.fl_str_mv |
HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population |
| title |
HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population |
| spellingShingle |
HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population Alencar, Liciana Xavier Eurico de Dengue Brasil epidemiologia Doenças Endêmicas, prevenção & controle. Dengue Brazil epidemiology Endemic Diseases, prevention & control estudos transversais Vírus da dengue Dengue prevenção & controle Infecção por Vírus da Dengue Humanos Vírus da Dengue genética Vírus da Dengue virologia Brasil epidemiologia Dengue Grave complicações Vírus da Dengue classificação DNA Feminino Masculino Índice de Gravidade de Doença Dengue Grave diagnóstico |
| title_short |
HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population |
| title_full |
HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population |
| title_fullStr |
HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population |
| title_full_unstemmed |
HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population |
| title_sort |
HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population |
| author |
Alencar, Liciana Xavier Eurico de |
| author_facet |
Alencar, Liciana Xavier Eurico de Braga-Neto, Ulisses de Mendonça Nascimento, Eduardo José Moura do Cordeiro, Marli Tenório Silva, Ana Maria Brito, Carlos Alexandre Antunes de Silva, Maria da Paz Carvalho da Gil, Laura Helena Vega Gonzales Montenegro, Silvia Maria Lucena Marques, Ernesto Torres de Azevedo |
| author_role |
author |
| author2 |
Braga-Neto, Ulisses de Mendonça Nascimento, Eduardo José Moura do Cordeiro, Marli Tenório Silva, Ana Maria Brito, Carlos Alexandre Antunes de Silva, Maria da Paz Carvalho da Gil, Laura Helena Vega Gonzales Montenegro, Silvia Maria Lucena Marques, Ernesto Torres de Azevedo |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Alencar, Liciana Xavier Eurico de Braga-Neto, Ulisses de Mendonça Nascimento, Eduardo José Moura do Cordeiro, Marli Tenório Silva, Ana Maria Brito, Carlos Alexandre Antunes de Silva, Maria da Paz Carvalho da Gil, Laura Helena Vega Gonzales Montenegro, Silvia Maria Lucena Marques, Ernesto Torres de Azevedo |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue Brasil epidemiologia Doenças Endêmicas, prevenção & controle. |
| topic |
Dengue Brasil epidemiologia Doenças Endêmicas, prevenção & controle. Dengue Brazil epidemiology Endemic Diseases, prevention & control estudos transversais Vírus da dengue Dengue prevenção & controle Infecção por Vírus da Dengue Humanos Vírus da Dengue genética Vírus da Dengue virologia Brasil epidemiologia Dengue Grave complicações Vírus da Dengue classificação DNA Feminino Masculino Índice de Gravidade de Doença Dengue Grave diagnóstico |
| dc.subject.en.pt_BR.fl_str_mv |
Dengue Brazil epidemiology Endemic Diseases, prevention & control |
| dc.subject.decs.pt_BR.fl_str_mv |
estudos transversais Vírus da dengue Dengue prevenção & controle Infecção por Vírus da Dengue Humanos Vírus da Dengue genética Vírus da Dengue virologia Brasil epidemiologia Dengue Grave complicações Vírus da Dengue classificação DNA Feminino Masculino Índice de Gravidade de Doença Dengue Grave diagnóstico |
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Fundaçao Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil. |
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2013 |
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2013 |
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2017-12-13T12:13:41Z |
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2017-12-13T12:13:41Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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ALENCAR, L. Xavier Eurico de et al. HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population. Journal of Tropical Medicine, v. 2013, p. 648475, 2013. |
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https://www.arca.fiocruz.br/handle/icict/23632 |
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1687-9686 |
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10.1155/2013/648475 |
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ALENCAR, L. Xavier Eurico de et al. HLA-B∗44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population. Journal of Tropical Medicine, v. 2013, p. 648475, 2013. 1687-9686 10.1155/2013/648475 |
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eng |
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eng |
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openAccess |
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Jean-Paul Gonzalez |
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Jean-Paul Gonzalez |
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