Human_leishmaniasis/cytokines.bahia.br
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/5670 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Barral Netto, ManoelBrodskyn, Claudia IdaCarvalho Filho, Edgar MarcelinoBarral, Aldina Maria Prado2012-10-15T21:08:03Z2012-10-15T21:08:03Z1998BARRAL-NETTO, M. et al. Human_leishmaniasis/cytokines.bahia.br. Brazilian Journal of Medical Biological Research, v. 31, n. 1, p. 149-55, jan. 1998.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/5670engHuman_leishmaniasis/cytokines.bahia.brinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilThe cell-mediated immune response is critical in the resistance to and recovery from leishmaniasis. Cytokines are central elements in mounting an immune response and have received a great deal of attention in both human and experimental leishmaniasis. IFN-gamma is responsible for macrophage activation leading to leishmanicidal mechanisms. Understanding the balance of cytokines that lead to enhanced production of or synergize with IFN-gamma, and those cytokines that counterbalance its effects is fundamental for developing rational immunotherapeutic or immunoprophylactic approaches to leishmaniasis. Here we focus on the cytokine balance in human leishmaniasis, particularly IL-10 as an IFN-gamma opposing cytokine, and IL-12 as an IFN-gamma inducer. The effects of these cytokines were evaluated in terms of several parameters of the human immune response. IL-10 reduced lymphocyte proliferation, IFN-gamma production and cytotoxic activity of responsive human peripheral blood mononuclear cells. Neutralization of IL-10 led to partial restoration of lymphoproliferation, IFN-gamma production and cytotoxic activity in unresponsive visceral leishmaniasis patients. IL-12 also restored the responses of peripheral blood mononuclear cells from visceral leishmaniasis patients. 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dc.title.pt_BR.fl_str_mv |
Human_leishmaniasis/cytokines.bahia.br |
title |
Human_leishmaniasis/cytokines.bahia.br |
spellingShingle |
Human_leishmaniasis/cytokines.bahia.br Barral Netto, Manoel Cytokines Human leishmaniasis Immunoregulation IL-12 IL-10 Citocinas/fisiologia Leishmaniose/imunologia Brasil Humanos Interleucina-10 Interleucina-12 |
title_short |
Human_leishmaniasis/cytokines.bahia.br |
title_full |
Human_leishmaniasis/cytokines.bahia.br |
title_fullStr |
Human_leishmaniasis/cytokines.bahia.br |
title_full_unstemmed |
Human_leishmaniasis/cytokines.bahia.br |
title_sort |
Human_leishmaniasis/cytokines.bahia.br |
author |
Barral Netto, Manoel |
author_facet |
Barral Netto, Manoel Brodskyn, Claudia Ida Carvalho Filho, Edgar Marcelino Barral, Aldina Maria Prado |
author_role |
author |
author2 |
Brodskyn, Claudia Ida Carvalho Filho, Edgar Marcelino Barral, Aldina Maria Prado |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Barral Netto, Manoel Brodskyn, Claudia Ida Carvalho Filho, Edgar Marcelino Barral, Aldina Maria Prado |
dc.subject.en.pt_BR.fl_str_mv |
Cytokines Human leishmaniasis Immunoregulation IL-12 IL-10 |
topic |
Cytokines Human leishmaniasis Immunoregulation IL-12 IL-10 Citocinas/fisiologia Leishmaniose/imunologia Brasil Humanos Interleucina-10 Interleucina-12 |
dc.subject.decs.pt_BR.fl_str_mv |
Citocinas/fisiologia Leishmaniose/imunologia Brasil Humanos Interleucina-10 Interleucina-12 |
description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
publishDate |
1998 |
dc.date.issued.fl_str_mv |
1998 |
dc.date.accessioned.fl_str_mv |
2012-10-15T21:08:03Z |
dc.date.available.fl_str_mv |
2012-10-15T21:08:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BARRAL-NETTO, M. et al. Human_leishmaniasis/cytokines.bahia.br. Brazilian Journal of Medical Biological Research, v. 31, n. 1, p. 149-55, jan. 1998. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/5670 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
identifier_str_mv |
BARRAL-NETTO, M. et al. Human_leishmaniasis/cytokines.bahia.br. Brazilian Journal of Medical Biological Research, v. 31, n. 1, p. 149-55, jan. 1998. 0100-879X |
url |
https://www.arca.fiocruz.br/handle/icict/5670 |
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eng |
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