Investigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing study

Detalhes bibliográficos
Autor(a) principal: Braet, Sofie Marijke
Data de Publicação: 2022
Outros Autores: Jouet, Agathe, Aubry, Alexandra, Van Dyck-Lippens, Magalie, Lenoir, Esteban, Assoumani, Younoussa, Baco, Abdallah, Mzembaba, Aboubacar, Cambau, Emmanuelle, Vasconcellos, Sidra Ezidio Gonçalves, Rigouts, Leen, Suffys, Philip Noel, Hasker, Epco, Supply, Philip, Jong, Bouke Catherine de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56025
Resumo: Lancet Microbe 2022 - 3: e693–700. Ver Autores e respectivas Afiliações: Institution of Tropical Medicine, Antwerp, Belgium (S Marijke Braet MSc, M Van Dyck-Lippens BSc, Prof L Rigouts PhD, Prof E Hasker PhD, B C de Jong MD); Department of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium (S Marijke Braet, Prof L Rigouts); Research Foundation Flanders, Brussels, Belgium (S Marijke Braet); GenoScreen, Lille, France (A Jouet PhD, E Lenoir MSc); Sorbonne Université, INSERM, Centre d’Immunologie et des Maladies Infectieuses (Prof A Aubry PhD) and Centre National de Référence des Mycobactéries et de la Résistance des mycobactéries aux antituberculeux (Prof A Aubry), Paris, France; Damien Foundation, Brussels, Belgium (Y Assoumani MD, A Baco MSc); National Tuberculosis and Leprosy Control Program, Moroni, Comoros (A Mzembaba MD); Inserm UMR 1137 Iame, service de mycobactériologie spécialisée et de référence, APHP GHU Paris Nord, Hôpital Bichat, Paris, France (Prof E Cambau PhD); Laboratory of Molecular Biology applied to Mycobacteria, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil (S E G Vasconcellos PhD, P N Suffys PhD); U1019-UMR 9017-CIIL, Université de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France (Prof P Supply PhD)
id CRUZ_3cedd72cd70649772159cc80a3cb9d60
oai_identifier_str oai:www.arca.fiocruz.br:icict/56025
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Braet, Sofie MarijkeJouet, AgatheAubry, AlexandraVan Dyck-Lippens, MagalieLenoir, EstebanAssoumani, YounoussaBaco, AbdallahMzembaba, AboubacarCambau, EmmanuelleVasconcellos, Sidra Ezidio GonçalvesRigouts, LeenSuffys, Philip NoelHasker, EpcoSupply, PhilipJong, Bouke Catherine de2022-12-17T18:54:45Z2022-12-17T18:54:45Z2022BRAET, Sofie Marijike et al. Investigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing study. Lancet Microbe, 3: e693-700, p. 1 - 8, July 2022.2666-5247https://www.arca.fiocruz.br/handle/icict/5602510.1016/ S2666-5247(22)00117-3Lancet Microbe 2022 - 3: e693–700. Ver Autores e respectivas Afiliações: Institution of Tropical Medicine, Antwerp, Belgium (S Marijke Braet MSc, M Van Dyck-Lippens BSc, Prof L Rigouts PhD, Prof E Hasker PhD, B C de Jong MD); Department of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium (S Marijke Braet, Prof L Rigouts); Research Foundation Flanders, Brussels, Belgium (S Marijke Braet); GenoScreen, Lille, France (A Jouet PhD, E Lenoir MSc); Sorbonne Université, INSERM, Centre d’Immunologie et des Maladies Infectieuses (Prof A Aubry PhD) and Centre National de Référence des Mycobactéries et de la Résistance des mycobactéries aux antituberculeux (Prof A Aubry), Paris, France; Damien Foundation, Brussels, Belgium (Y Assoumani MD, A Baco MSc); National Tuberculosis and Leprosy Control Program, Moroni, Comoros (A Mzembaba MD); Inserm UMR 1137 Iame, service de mycobactériologie spécialisée et de référence, APHP GHU Paris Nord, Hôpital Bichat, Paris, France (Prof E Cambau PhD); Laboratory of Molecular Biology applied to Mycobacteria, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil (S E G Vasconcellos PhD, P N Suffys PhD); U1019-UMR 9017-CIIL, Université de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France (Prof P Supply PhD)Ver em NOTAS - Autores e respectivas afiliações.Despite strong leprosy control measures, including effective treatment, leprosy persists in the Comoros. As of May, 2022, no resistance to anti-leprosy drugs had been reported, but there are no nationally representative data. Post-exposure prophylaxis (PEP) with rifampicin is offered to contacts of patients with leprosy. We aimed to conduct a countrywide drug resistance survey and investigate whether PEP led to the emergence of drug resistance in patients with leprosy.engElsevier Ltd.Mycobacterium lepraeInvestigando a resistência a drogasComorosEstudo observacional de sequenciamento profundoMycobacterium lepraeInvestigating drug resistanceComorosObservational deep-sequencing studyInvestigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56025/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSidraVasconcelos_PhilipNoelSuffys_etal_IOc_2022.pdfSidraVasconcelos_PhilipNoelSuffys_etal_IOc_2022.pdfapplication/pdf465166https://www.arca.fiocruz.br/bitstream/icict/56025/2/SidraVasconcelos_PhilipNoelSuffys_etal_IOc_2022.pdf6c59be82fff88f7833eac2e98bf7b50fMD52icict/560252023-09-04 11:03:04.63oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:03:04Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Investigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing study
title Investigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing study
spellingShingle Investigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing study
Braet, Sofie Marijke
Mycobacterium leprae
Investigando a resistência a drogas
Comoros
Estudo observacional de sequenciamento profundo
Mycobacterium leprae
Investigating drug resistance
Comoros
Observational deep-sequencing study
title_short Investigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing study
title_full Investigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing study
title_fullStr Investigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing study
title_full_unstemmed Investigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing study
title_sort Investigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing study
author Braet, Sofie Marijke
author_facet Braet, Sofie Marijke
Jouet, Agathe
Aubry, Alexandra
Van Dyck-Lippens, Magalie
Lenoir, Esteban
Assoumani, Younoussa
Baco, Abdallah
Mzembaba, Aboubacar
Cambau, Emmanuelle
Vasconcellos, Sidra Ezidio Gonçalves
Rigouts, Leen
Suffys, Philip Noel
Hasker, Epco
Supply, Philip
Jong, Bouke Catherine de
author_role author
author2 Jouet, Agathe
Aubry, Alexandra
Van Dyck-Lippens, Magalie
Lenoir, Esteban
Assoumani, Younoussa
Baco, Abdallah
Mzembaba, Aboubacar
Cambau, Emmanuelle
Vasconcellos, Sidra Ezidio Gonçalves
Rigouts, Leen
Suffys, Philip Noel
Hasker, Epco
Supply, Philip
Jong, Bouke Catherine de
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Braet, Sofie Marijke
Jouet, Agathe
Aubry, Alexandra
Van Dyck-Lippens, Magalie
Lenoir, Esteban
Assoumani, Younoussa
Baco, Abdallah
Mzembaba, Aboubacar
Cambau, Emmanuelle
Vasconcellos, Sidra Ezidio Gonçalves
Rigouts, Leen
Suffys, Philip Noel
Hasker, Epco
Supply, Philip
Jong, Bouke Catherine de
dc.subject.other.en_US.fl_str_mv Mycobacterium leprae
Investigando a resistência a drogas
Comoros
Estudo observacional de sequenciamento profundo
topic Mycobacterium leprae
Investigando a resistência a drogas
Comoros
Estudo observacional de sequenciamento profundo
Mycobacterium leprae
Investigating drug resistance
Comoros
Observational deep-sequencing study
dc.subject.en.en_US.fl_str_mv Mycobacterium leprae
Investigating drug resistance
Comoros
Observational deep-sequencing study
description Lancet Microbe 2022 - 3: e693–700. Ver Autores e respectivas Afiliações: Institution of Tropical Medicine, Antwerp, Belgium (S Marijke Braet MSc, M Van Dyck-Lippens BSc, Prof L Rigouts PhD, Prof E Hasker PhD, B C de Jong MD); Department of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium (S Marijke Braet, Prof L Rigouts); Research Foundation Flanders, Brussels, Belgium (S Marijke Braet); GenoScreen, Lille, France (A Jouet PhD, E Lenoir MSc); Sorbonne Université, INSERM, Centre d’Immunologie et des Maladies Infectieuses (Prof A Aubry PhD) and Centre National de Référence des Mycobactéries et de la Résistance des mycobactéries aux antituberculeux (Prof A Aubry), Paris, France; Damien Foundation, Brussels, Belgium (Y Assoumani MD, A Baco MSc); National Tuberculosis and Leprosy Control Program, Moroni, Comoros (A Mzembaba MD); Inserm UMR 1137 Iame, service de mycobactériologie spécialisée et de référence, APHP GHU Paris Nord, Hôpital Bichat, Paris, France (Prof E Cambau PhD); Laboratory of Molecular Biology applied to Mycobacteria, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil (S E G Vasconcellos PhD, P N Suffys PhD); U1019-UMR 9017-CIIL, Université de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France (Prof P Supply PhD)
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-12-17T18:54:45Z
dc.date.available.fl_str_mv 2022-12-17T18:54:45Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BRAET, Sofie Marijike et al. Investigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing study. Lancet Microbe, 3: e693-700, p. 1 - 8, July 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56025
dc.identifier.issn.en_US.fl_str_mv 2666-5247
dc.identifier.doi.none.fl_str_mv 10.1016/ S2666-5247(22)00117-3
identifier_str_mv BRAET, Sofie Marijike et al. Investigating drug resistance of Mycobacterium leprae in the Comoros: an observational deep-sequencing study. Lancet Microbe, 3: e693-700, p. 1 - 8, July 2022.
2666-5247
10.1016/ S2666-5247(22)00117-3
url https://www.arca.fiocruz.br/handle/icict/56025
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Ltd.
publisher.none.fl_str_mv Elsevier Ltd.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56025/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56025/2/SidraVasconcelos_PhilipNoelSuffys_etal_IOc_2022.pdf
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
6c59be82fff88f7833eac2e98bf7b50f
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009057340981248

Registros relacionados