Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach.

Detalhes bibliográficos
Autor(a) principal: Pompeu, Margarida Maria de Lima
Data de Publicação: 1991
Outros Autores: Freitas, Luiz Antonio Rodrigues de, Santos, M. L. V, Khouri, M, Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7621
Resumo: Universidade Federal do Ceará. Departamentos de Patologia. Fortaleza, CE, Brasil
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spelling Pompeu, Margarida Maria de LimaFreitas, Luiz Antonio Rodrigues deSantos, M. L. VKhouri, MBarral Netto, Manoel2014-05-14T14:01:27Z2014-05-14T14:01:27Z1991POMPEU, M. L. et al. Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach. Acta Tropica, v. 48, n. 3, p. 185-193, 1991.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/7621engElsevierGranulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Ceará. Departamentos de Patologia. Fortaleza, CE, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, BrasilWe used previously immunized (partially resistant) and naive (highly susceptible) BALB/c mice infected with Leishrnania amazonensis for evaluating the role of granulocytes in the course of murine leishmaniasis. The animals were examined at different times post-infection and granulocytes counted in lesion tissues examined ultra-structurally. Polymorphonuclear granulocytes predominated during the early phase of infection and their number decreased with progression of infection; their number was similar in both groups during the early and intermediate phases of infection, though slightly higher in immunized animals during the late phase. Eosinophils represented approximately 10% of cells in the inflammatory infiltrate, being higher during the intermediate phase, and not differing between the groups. Another approach was the evaluation of granulocyte migration to the peritoneal cavity of susceptible BALB/c mice or resistant C57BL/6 mice under several stimuli. There was no statistically significant difference between resistant and susceptible animals in any of the treatments. Despite the influx of granulocytes to the lesion and its possible role in the initial destruction of injected Leishmania, this aspect does not seem to have an important effect on the outcome of the leishmanial infection.LeishmaniasisLeishmania amazonensisGranulocytesNeutrophilsEosinophilsGranulócitos/fisiologiaLeishmaniose/patologiaAnimaisMovimento CelularModelos Animais de DoençasEosinófilos/imunologiaGranulócitos/imunologiaLeishmania/imunologiaLeishmaniose/imunologiaContagem de LeucócitosCamundongosCamundongos Endogâmicos BALB CNeutrófilos/imunologiaCavidade Peritoneal/patologiaFagocitoseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPompeu M L Granulocytes in the....pdfPompeu M L Granulocytes in the....pdfapplication/pdf761633https://www.arca.fiocruz.br/bitstream/icict/7621/1/Pompeu%20M%20L%20Granulocytes%20in%20the....pdf1cdc60f9cc01f426482eb6fed802e1b4MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7621/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTPompeu M L Granulocytes in the....pdf.txtPompeu M L Granulocytes in the....pdf.txtExtracted texttext/plain25969https://www.arca.fiocruz.br/bitstream/icict/7621/5/Pompeu%20M%20L%20Granulocytes%20in%20the....pdf.txtf4bf15d848e8c30df6ddfa7c8bd043d2MD55THUMBNAILPompeu M L Granulocytes in the....pdf.jpgPompeu M L Granulocytes in the....pdf.jpgGenerated Thumbnailimage/jpeg1884https://www.arca.fiocruz.br/bitstream/icict/7621/4/Pompeu%20M%20L%20Granulocytes%20in%20the....pdf.jpgcbe1e6cf92416dc4da192e6de57be181MD54icict/76212023-03-15 14:33:18.651oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach.
title Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach.
spellingShingle Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach.
Pompeu, Margarida Maria de Lima
Leishmaniasis
Leishmania amazonensis
Granulocytes
Neutrophils
Eosinophils
Granulócitos/fisiologia
Leishmaniose/patologia
Animais
Movimento Celular
Modelos Animais de Doenças
Eosinófilos/imunologia
Granulócitos/imunologia
Leishmania/imunologia
Leishmaniose/imunologia
Contagem de Leucócitos
Camundongos
Camundongos Endogâmicos BALB C
Neutrófilos/imunologia
Cavidade Peritoneal/patologia
Fagocitose
title_short Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach.
title_full Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach.
title_fullStr Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach.
title_full_unstemmed Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach.
title_sort Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach.
author Pompeu, Margarida Maria de Lima
author_facet Pompeu, Margarida Maria de Lima
Freitas, Luiz Antonio Rodrigues de
Santos, M. L. V
Khouri, M
Barral Netto, Manoel
author_role author
author2 Freitas, Luiz Antonio Rodrigues de
Santos, M. L. V
Khouri, M
Barral Netto, Manoel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pompeu, Margarida Maria de Lima
Freitas, Luiz Antonio Rodrigues de
Santos, M. L. V
Khouri, M
Barral Netto, Manoel
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis
Leishmania amazonensis
Granulocytes
Neutrophils
Eosinophils
topic Leishmaniasis
Leishmania amazonensis
Granulocytes
Neutrophils
Eosinophils
Granulócitos/fisiologia
Leishmaniose/patologia
Animais
Movimento Celular
Modelos Animais de Doenças
Eosinófilos/imunologia
Granulócitos/imunologia
Leishmania/imunologia
Leishmaniose/imunologia
Contagem de Leucócitos
Camundongos
Camundongos Endogâmicos BALB C
Neutrófilos/imunologia
Cavidade Peritoneal/patologia
Fagocitose
dc.subject.decs.pt_BR.fl_str_mv Granulócitos/fisiologia
Leishmaniose/patologia
Animais
Movimento Celular
Modelos Animais de Doenças
Eosinófilos/imunologia
Granulócitos/imunologia
Leishmania/imunologia
Leishmaniose/imunologia
Contagem de Leucócitos
Camundongos
Camundongos Endogâmicos BALB C
Neutrófilos/imunologia
Cavidade Peritoneal/patologia
Fagocitose
description Universidade Federal do Ceará. Departamentos de Patologia. Fortaleza, CE, Brasil
publishDate 1991
dc.date.issued.fl_str_mv 1991
dc.date.accessioned.fl_str_mv 2014-05-14T14:01:27Z
dc.date.available.fl_str_mv 2014-05-14T14:01:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv POMPEU, M. L. et al. Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach. Acta Tropica, v. 48, n. 3, p. 185-193, 1991.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7621
dc.identifier.issn.none.fl_str_mv 0001-706X
identifier_str_mv POMPEU, M. L. et al. Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach. Acta Tropica, v. 48, n. 3, p. 185-193, 1991.
0001-706X
url https://www.arca.fiocruz.br/handle/icict/7621
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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