Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected

Detalhes bibliográficos
Autor(a) principal: Pompeu, Margarida Maria de Lima
Data de Publicação: 1992
Outros Autores: Freitas, Luiz Antonio Rodrigues de, Santos, M. L. V, Barral, Aldina Maria Prado, Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7908
Resumo: Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
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spelling Pompeu, Margarida Maria de LimaFreitas, Luiz Antonio Rodrigues deSantos, M. L. VBarral, Aldina Maria PradoBarral Netto, Manoel2014-07-10T16:43:11Z2014-07-10T16:43:11Z1992POMPEU, M. L. et al. Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected. Experimental Parasitology, v. 74, n. 2, p. 169-176, 1992.0014-4894https://www.arca.fiocruz.br/handle/icict/7908engAcademic Press Inc.Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infectedinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, BrasilIn vitro studies have shown that both macrophage activation and destruction of parasitized macrophages lead to leishmania destruction. The relative role played by such mechanisms in vivo have not been properly evaluated. We took advantage of the model of intravenous immunization with solubilized leishmanial antigen which renders partially resistant the otherwise highly susceptible BALB/c mice to address this issue avoiding the interference of different genetic backgrounds. Leishmania destruction occurred in three situations: destruction of the parasitized macrophage, which were in close contact with lymphocytes or eosinophils; extracellular damage, always surrounded by small foci of granulocytes; and parasite damage inside activated macrophages. Destruction of the parasitized macrophages was frequently seen in immunized and protected animals. Our observations suggest that destruction of parasite-loaded macrophages is an important mechanism of host protection in experimental cutaneous leishmaniasis.Leishmania amazonensis;LeishmaniasisImmunizationLeishmaniaTegumentary leishmaniasisExperimental leishmaniasisImunizaçãoLeishmania mexicana/imunologiaLeishmaniose Cutânea/imunologiaAtivação de MacrófagosMacrófagos/imunologiaAnimaisEosinófilos/imunologiaGranulócitos/imunologiaLeishmania mexicana/ultraestruturaMacrófagos/parasitologiaCamundongosCamundongos Endogâmicos BALB CMicroscopia Eletrônicainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPompeu ML Leishmania amazonensis infection....pdfPompeu ML Leishmania amazonensis infection....pdfapplication/pdf3311751https://www.arca.fiocruz.br/bitstream/icict/7908/1/Pompeu%20ML%20Leishmania%20amazonensis%20infection....pdf97d1f63631d0cb4cdb12219d0eedd179MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7908/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTPompeu ML Leishmania amazonensis infection....pdf.txtPompeu ML Leishmania amazonensis infection....pdf.txtExtracted texttext/plain20998https://www.arca.fiocruz.br/bitstream/icict/7908/3/Pompeu%20ML%20Leishmania%20amazonensis%20infection....pdf.txt09374214176c29e272d9247cb742ae1fMD53icict/79082023-03-15 14:33:19.061oai:www.arca.fiocruz.br:icict/7908TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected
title Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected
spellingShingle Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected
Pompeu, Margarida Maria de Lima
Leishmania amazonensis;
Leishmaniasis
Immunization
Leishmania
Tegumentary leishmaniasis
Experimental leishmaniasis
Imunização
Leishmania mexicana/imunologia
Leishmaniose Cutânea/imunologia
Ativação de Macrófagos
Macrófagos/imunologia
Animais
Eosinófilos/imunologia
Granulócitos/imunologia
Leishmania mexicana/ultraestrutura
Macrófagos/parasitologia
Camundongos
Camundongos Endogâmicos BALB C
Microscopia Eletrônica
title_short Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected
title_full Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected
title_fullStr Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected
title_full_unstemmed Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected
title_sort Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected
author Pompeu, Margarida Maria de Lima
author_facet Pompeu, Margarida Maria de Lima
Freitas, Luiz Antonio Rodrigues de
Santos, M. L. V
Barral, Aldina Maria Prado
Barral Netto, Manoel
author_role author
author2 Freitas, Luiz Antonio Rodrigues de
Santos, M. L. V
Barral, Aldina Maria Prado
Barral Netto, Manoel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pompeu, Margarida Maria de Lima
Freitas, Luiz Antonio Rodrigues de
Santos, M. L. V
Barral, Aldina Maria Prado
Barral Netto, Manoel
dc.subject.en.pt_BR.fl_str_mv Leishmania amazonensis;
Leishmaniasis
Immunization
Leishmania
Tegumentary leishmaniasis
Experimental leishmaniasis
topic Leishmania amazonensis;
Leishmaniasis
Immunization
Leishmania
Tegumentary leishmaniasis
Experimental leishmaniasis
Imunização
Leishmania mexicana/imunologia
Leishmaniose Cutânea/imunologia
Ativação de Macrófagos
Macrófagos/imunologia
Animais
Eosinófilos/imunologia
Granulócitos/imunologia
Leishmania mexicana/ultraestrutura
Macrófagos/parasitologia
Camundongos
Camundongos Endogâmicos BALB C
Microscopia Eletrônica
dc.subject.decs.pt_BR.fl_str_mv Imunização
Leishmania mexicana/imunologia
Leishmaniose Cutânea/imunologia
Ativação de Macrófagos
Macrófagos/imunologia
Animais
Eosinófilos/imunologia
Granulócitos/imunologia
Leishmania mexicana/ultraestrutura
Macrófagos/parasitologia
Camundongos
Camundongos Endogâmicos BALB C
Microscopia Eletrônica
description Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2014-07-10T16:43:11Z
dc.date.available.fl_str_mv 2014-07-10T16:43:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv POMPEU, M. L. et al. Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected. Experimental Parasitology, v. 74, n. 2, p. 169-176, 1992.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7908
dc.identifier.issn.none.fl_str_mv 0014-4894
identifier_str_mv POMPEU, M. L. et al. Leishmania amazonensis infection: a comparison of in vivo leishmanicidal mechanisms between immunized and naive infected. Experimental Parasitology, v. 74, n. 2, p. 169-176, 1992.
0014-4894
url https://www.arca.fiocruz.br/handle/icict/7908
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Academic Press Inc.
publisher.none.fl_str_mv Academic Press Inc.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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