Re‑emergence of Gamma‑like‑II and emergence of Gamma‑S:E661D SARS‑CoV‑2 lineages in the south of Brazil after the 2021 outbreak
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50351 |
Resumo: | A Rede Genômica Fiocruz é formada por especialistas de todas as unidades da Fundação no país e de institutos parceiros que se empenham diariamente em gerar dados mais robustos sobre o comportamento do SARS-Cov-2 e contribuir para um melhor preparo do país no enfrentamento da pandemia em termos de diagnóstico mais precisos e vacinas eficazes. Saiba mais sobre a Rede Genômica Fiocruz em: http://www.genomahcov.fiocruz.br/ |
| id |
CRUZ_3e5f4fd8e0bbdbb84eb198e24ffee5da |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/50351 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Oliveira, Mauro M.Schemberger, Michelle O.Suzukawa, Andréia AkemiRiediger, Irina N.Debur, Maria do CarmoBecker, GuilhermeResende, Paola CristinaGräf, TiagoBalsanelli, EduardoBaura, Valter Antônio deSouza, Emanuel Maltempi dePedrosa, Fábio O.Alves, Lysangela RonalteBlanes, LucasNardelli, Sheila CristinaAguiar, Alessandra Melo deAlbrecht, LetusaZanette, DalilaÁvila, Andréa RodriguesMorello, Luis GustavoMarchini, Fabrício KleryntonSantos, Hellen Geremias dosPassetti, FabioDallagiovanna, BrunoFaoro, Helisson2021-12-13T18:30:47Z2021-12-13T18:30:47Z2021OLIVEIRA, Mauro M. et al. Re‑emergence of Gamma‑like‑II and emergence of Gamma‑S:E661D SARS‑CoV‑2 lineages in the south of Brazil after the 2021 outbreak. Virology Journal, v.18, n. 222, p. 1-14, 2021.1743-422Xhttps://www.arca.fiocruz.br/handle/icict/5035110.1186/s12985-021-01690-1A Rede Genômica Fiocruz é formada por especialistas de todas as unidades da Fundação no país e de institutos parceiros que se empenham diariamente em gerar dados mais robustos sobre o comportamento do SARS-Cov-2 e contribuir para um melhor preparo do país no enfrentamento da pandemia em termos de diagnóstico mais precisos e vacinas eficazes. Saiba mais sobre a Rede Genômica Fiocruz em: http://www.genomahcov.fiocruz.br/Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Laboratório Central do Estado do Paraná. Curitiba, PR, Brasil.Laboratório Central do Estado do Paraná. Curitiba, PR, Brasil.Laboratório Central do Estado do Paraná. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratórios de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Pesquisa em Apicomplexa. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Pesquisa em Apicomplexa. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Pesquisa em Apicomplexa. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Background: We report a genomic surveillance of SARS-CoV-2 lineages circulating in Paraná, southern Brazil, from March 2020 to April 2021. Our analysis, based on 333 genomes, revealed that the frst variants detected in the state of Paraná in March 2020 were the B.1.1.33 and B.1.1.28 variants. The variants B.1.1.28 and B.1.1.33 were predominant throughout 2020 until the introduction of the variant P.2 in August 2020 and a variant of concern (VOC), Gamma (P.1), in January 2021. The VOC Gamma, a ramifcation of the B.1.1.28 lineage frst detected in Manaus (northern Brazil), has grown rapidly since December 2020 and was thought to be responsible for the deadly second wave of COVID-19 throughout Brazil. Methods: The 333 genomic sequences of SARS-CoV-2 from March 2020 to April 2021 were generated as part of the genomic surveillance carried out by Fiocruz in Brazil Genomahcov Fiocruz. SARS-CoV-2 sequencing was performed using representative samples from all geographic areas of Paraná. Phylogenetic analyses were performed using the 333 genomes also included other SARS-CoV-2 genomes from the state of Paraná and other states in Brazil that were deposited in the GISAID. In addition, the time-scaled phylogenetic tree was constructed with up to 3 random sequences of the Gamma variant from each state in Brazil in each month of 2021. In this analysis we also added the sequences identifed as the B.1.1.28 lineage of the Amazonas state and and the Gamma-like-II (P.1-like-II) lineage identifed in diferent regions of Brazil. Results: Phylogenetic analyses of the SARS-CoV-2 genomes that were previously classifed as the VOC Gamma lineage by WHO/PANGO showed that some genomes from February to April 2021 branched in a monophyletic clade and that these samples grouped together with genomes recently described with the lineage Gamma-like-II. Additionally, a new mutation (E661D) in the spike (S) protein has been identifed in nearly 10% of the genomes classifed as the VOC Gamma from Paraná in March and April 2021.Finally, we analyzed the correlation between the lineage and the Gamma variant frequency, age group (patients younger or older than 60 years old) and the clinical data of 86 cases from the state of Paraná. Conclusions: Our results provided a reliable picture of the evolution of the SARS-CoV-2 pandemic in the state of Paraná characterized by the dominance of the Gamma strain, as well as a high frequencies of the Gamma-like-II lineage and the S:E661D mutation. Epidemiological and genomic surveillance eforts should be continued to unveil the biological relevance of the novel mutations detected in the VOC Gamma in Paraná.porBMCAnálise FilogenéticaSARS-CoV-2Variante B.1.1.33Variante B.1.1.28GammaGamma-like-IIRede Genômica FiocruzGENOMAHCOVPhylogenetic analysesPhylogenyMutationFilogeniaMutaciónPhylogenèseMutationFilogeniaCOVID-19MutaçãoRe‑emergence of Gamma‑like‑II and emergence of Gamma‑S:E661D SARS‑CoV‑2 lineages in the south of Brazil after the 2021 outbreakinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/50351/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALs12985-021-01690OK.pdfs12985-021-01690OK.pdfapplication/pdf2625664https://www.arca.fiocruz.br/bitstream/icict/50351/2/s12985-021-01690OK.pdf6444975175977676db534fcbe1908b75MD52_AUTORIZACAO_DEPOSITO_ARCA_REDE_GENOMICA.pdf_AUTORIZACAO_DEPOSITO_ARCA_REDE_GENOMICA.pdfapplication/pdf134844https://www.arca.fiocruz.br/bitstream/icict/50351/3/_AUTORIZACAO_DEPOSITO_ARCA_REDE_GENOMICA.pdf28ef5cd96257018f624857e2ce8ab529MD53icict/503512022-04-27 15:04:10.98oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-04-27T18:04:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Re‑emergence of Gamma‑like‑II and emergence of Gamma‑S:E661D SARS‑CoV‑2 lineages in the south of Brazil after the 2021 outbreak |
| title |
Re‑emergence of Gamma‑like‑II and emergence of Gamma‑S:E661D SARS‑CoV‑2 lineages in the south of Brazil after the 2021 outbreak |
| spellingShingle |
Re‑emergence of Gamma‑like‑II and emergence of Gamma‑S:E661D SARS‑CoV‑2 lineages in the south of Brazil after the 2021 outbreak Oliveira, Mauro M. Análise Filogenética SARS-CoV-2 Variante B.1.1.33 Variante B.1.1.28 Gamma Gamma-like-II Rede Genômica Fiocruz GENOMAHCOV Phylogenetic analyses Phylogeny Mutation Filogenia Mutación Phylogenèse Mutation Filogenia COVID-19 Mutação |
| title_short |
Re‑emergence of Gamma‑like‑II and emergence of Gamma‑S:E661D SARS‑CoV‑2 lineages in the south of Brazil after the 2021 outbreak |
| title_full |
Re‑emergence of Gamma‑like‑II and emergence of Gamma‑S:E661D SARS‑CoV‑2 lineages in the south of Brazil after the 2021 outbreak |
| title_fullStr |
Re‑emergence of Gamma‑like‑II and emergence of Gamma‑S:E661D SARS‑CoV‑2 lineages in the south of Brazil after the 2021 outbreak |
| title_full_unstemmed |
Re‑emergence of Gamma‑like‑II and emergence of Gamma‑S:E661D SARS‑CoV‑2 lineages in the south of Brazil after the 2021 outbreak |
| title_sort |
Re‑emergence of Gamma‑like‑II and emergence of Gamma‑S:E661D SARS‑CoV‑2 lineages in the south of Brazil after the 2021 outbreak |
| author |
Oliveira, Mauro M. |
| author_facet |
Oliveira, Mauro M. Schemberger, Michelle O. Suzukawa, Andréia Akemi Riediger, Irina N. Debur, Maria do Carmo Becker, Guilherme Resende, Paola Cristina Gräf, Tiago Balsanelli, Eduardo Baura, Valter Antônio de Souza, Emanuel Maltempi de Pedrosa, Fábio O. Alves, Lysangela Ronalte Blanes, Lucas Nardelli, Sheila Cristina Aguiar, Alessandra Melo de Albrecht, Letusa Zanette, Dalila Ávila, Andréa Rodrigues Morello, Luis Gustavo Marchini, Fabrício Klerynton Santos, Hellen Geremias dos Passetti, Fabio Dallagiovanna, Bruno Faoro, Helisson |
| author_role |
author |
| author2 |
Schemberger, Michelle O. Suzukawa, Andréia Akemi Riediger, Irina N. Debur, Maria do Carmo Becker, Guilherme Resende, Paola Cristina Gräf, Tiago Balsanelli, Eduardo Baura, Valter Antônio de Souza, Emanuel Maltempi de Pedrosa, Fábio O. Alves, Lysangela Ronalte Blanes, Lucas Nardelli, Sheila Cristina Aguiar, Alessandra Melo de Albrecht, Letusa Zanette, Dalila Ávila, Andréa Rodrigues Morello, Luis Gustavo Marchini, Fabrício Klerynton Santos, Hellen Geremias dos Passetti, Fabio Dallagiovanna, Bruno Faoro, Helisson |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Mauro M. Schemberger, Michelle O. Suzukawa, Andréia Akemi Riediger, Irina N. Debur, Maria do Carmo Becker, Guilherme Resende, Paola Cristina Gräf, Tiago Balsanelli, Eduardo Baura, Valter Antônio de Souza, Emanuel Maltempi de Pedrosa, Fábio O. Alves, Lysangela Ronalte Blanes, Lucas Nardelli, Sheila Cristina Aguiar, Alessandra Melo de Albrecht, Letusa Zanette, Dalila Ávila, Andréa Rodrigues Morello, Luis Gustavo Marchini, Fabrício Klerynton Santos, Hellen Geremias dos Passetti, Fabio Dallagiovanna, Bruno Faoro, Helisson |
| dc.subject.other.pt_BR.fl_str_mv |
Análise Filogenética SARS-CoV-2 Variante B.1.1.33 Variante B.1.1.28 Gamma Gamma-like-II Rede Genômica Fiocruz GENOMAHCOV |
| topic |
Análise Filogenética SARS-CoV-2 Variante B.1.1.33 Variante B.1.1.28 Gamma Gamma-like-II Rede Genômica Fiocruz GENOMAHCOV Phylogenetic analyses Phylogeny Mutation Filogenia Mutación Phylogenèse Mutation Filogenia COVID-19 Mutação |
| dc.subject.en.pt_BR.fl_str_mv |
Phylogenetic analyses Phylogeny Mutation |
| dc.subject.es.pt_BR.fl_str_mv |
Filogenia Mutación |
| dc.subject.fr.pt_BR.fl_str_mv |
Phylogenèse Mutation |
| dc.subject.decs.pt_BR.fl_str_mv |
Filogenia COVID-19 Mutação |
| description |
A Rede Genômica Fiocruz é formada por especialistas de todas as unidades da Fundação no país e de institutos parceiros que se empenham diariamente em gerar dados mais robustos sobre o comportamento do SARS-Cov-2 e contribuir para um melhor preparo do país no enfrentamento da pandemia em termos de diagnóstico mais precisos e vacinas eficazes. Saiba mais sobre a Rede Genômica Fiocruz em: http://www.genomahcov.fiocruz.br/ |
| publishDate |
2021 |
| dc.date.accessioned.fl_str_mv |
2021-12-13T18:30:47Z |
| dc.date.available.fl_str_mv |
2021-12-13T18:30:47Z |
| dc.date.issued.fl_str_mv |
2021 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
OLIVEIRA, Mauro M. et al. Re‑emergence of Gamma‑like‑II and emergence of Gamma‑S:E661D SARS‑CoV‑2 lineages in the south of Brazil after the 2021 outbreak. Virology Journal, v.18, n. 222, p. 1-14, 2021. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/50351 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1743-422X |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s12985-021-01690-1 |
| identifier_str_mv |
OLIVEIRA, Mauro M. et al. Re‑emergence of Gamma‑like‑II and emergence of Gamma‑S:E661D SARS‑CoV‑2 lineages in the south of Brazil after the 2021 outbreak. Virology Journal, v.18, n. 222, p. 1-14, 2021. 1743-422X 10.1186/s12985-021-01690-1 |
| url |
https://www.arca.fiocruz.br/handle/icict/50351 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
BMC |
| publisher.none.fl_str_mv |
BMC |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/50351/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/50351/2/s12985-021-01690OK.pdf https://www.arca.fiocruz.br/bitstream/icict/50351/3/_AUTORIZACAO_DEPOSITO_ARCA_REDE_GENOMICA.pdf |
| bitstream.checksum.fl_str_mv |
783568c2893d2e25a99990b126be1772 6444975175977676db534fcbe1908b75 28ef5cd96257018f624857e2ce8ab529 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009252559618048 |